The Emerging Roles of Chromogranins and Derived Polypeptides in Atherosclerosis, Diabetes, and Coronary Heart Disease

Watanabe, Takuya

doi:10.3390/ijms22116118

Cited by 15 publications

(5 citation statements)

References 143 publications

(240 reference statements)

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“…We did not observe one specific trend for all the indicated substances. This finding confirms previous reports showing that these substances could be associated with the T1D course and various late complications [ 26 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ].…”

Section: Discussionsupporting

confidence: 92%

“…In a number of studies, selected biologically active substances were indicated as contributing to the etiology (IAPP [ 16 , 31 , 32 , 33 , 34 , 35 , 36 ], proIAPP [ 17 , 18 , 37 ], I-FABP [ 24 ]), course (CST [ 38 , 39 ], ChgA [ 40 , 41 , 42 ]) or the development of various complications (neuropathy—NGF [ 43 , 44 , 45 ], cardiovascular complications—PAF [ 26 , 46 , 47 ], and cardiovascular complications and nephropatia—UMOD [ 28 , 48 , 49 ]). In the current study, we assessed the diagnostic usefulness of these indicators present in T1D patients’ sera and confirmed statistically significant differences between their concentrations in the group of children with T1D and healthy children, but only some of them (NGF, ChgA, CST and PAF) were affected by disease duration.…”

Section: Discussionmentioning

confidence: 99%

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Selected Serum Markers Associated with Pathogenesis and Clinical Course of Type 1 Diabetes in Pediatric Patients—The Effect of Disease Duration

Ochocińska

Wysocka‐Mincewicz

Swiderska

et al. 2023

JCM

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Biochemical abnormalities in the course of type 1 diabetes (T1D) may cause the production/activation of various proteins and peptides influencing treatment and causing a risk of complications. The aim of this study was to assess concentrations of selected serum substances involved in the pathogenesis and course of T1D and to correlate their concentrations with the duration of T1D. The study included patients with T1D (n = 156) at the age of 3–17, who were divided according to the duration of the disease into those newly diagnosed (n = 30), diagnosed after 3–5 (n = 77), 6–7 (n = 25), and over 7 (n = 24) years from the onset of T1D, and age-matched healthy controls (n = 30). Concentrations of amylin (IAPP), proamylin (proIAPP), catestatin (CST), chromogranin A (ChgA), nerve growth factor (NFG), platelet-activating factor (PAF), uromodulin (UMOD), and intestinal fatty acid binding protein (I-FABP) were measured in sera using immunoenzymatic tests. There were significant differences in concentrations of all the substances except UMOD and NGF between T1D patients and healthy children. The duration of the disease affected concentrations of CST, ChgA, PAF, and NGF, i.e., proteins/peptides which could have an impact on the course of T1D and the development of complications. In long-term patients, a decrease in concentrations of CST and ChgA, and an increase in PAF concentrations were found. In the case of NGF, a decrease was observed after the initial high values, followed by an increase over 7 years after T1D diagnosis. Concluding, the results show that concentrations of selected serum indicators may change in the course of T1D. Further studies are needed to establish whether these indicators could be used in the context of predicting long-term complications.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Selected Serum Markers Associated with Pathogenesis and Clinical Course of Type 1 Diabetes in Pediatric Patients—The Effect of Disease Duration

Ochocińska

Wysocka‐Mincewicz

Swiderska

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…And its mortality is increasing year by year, which is one of the important reasons for the high clinical mortality [10]. e degree of atherosclerosis is the reflection of the evolution of CHD to a certain degree [11], so it is undoubtedly essential to evaluate the measure in atherosclerosis. For the moment, CAG is widely used in clinical diagnosis of coronary atherosclerosis, but its invasive operation has limited its clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Correlation Analysis of CML, sRAGE, and esRAGE and the Measure of Atherosclerosis of Coronary Heart Disease

Liu

Zhang

et al. 2022

Computational Intelligence and Neuroscience

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Objective. To investigate the correlation between CML, sRAGE, and esRAGE and the measure of atherosclerosis of coronary heart disease. Methods. From June 2019 to December 2021, there were 100 patients in all suffering from coronary heart disease (CHD) selected as the observation group. On the basis of Gensini score, they were divided into mild group (Gensini score < 12 points), moderate group (12 points ≤ Gensini score ≤60 points), and severe group (Gensini score > 60). Apart from that, 50 normal people staying in our hospital for physical examination were chosen as the control group in the meantime. N in each group was detected and compared ε-Carboxymethyl lysine (CML), soluble advanced glycation end product receptor (sRAGE), and endogenous secretory advanced glycation end product receptor (esRAGE). Pearson correlation coefficient was adapted to assay the relevance between CML, sRAGE, and esRAGE, as well as the degree of atherosclerosis in CHD. Receiver operator characteristic (ROC) curve was applied to during the evaluation of the diagnosis of CML, sRAGE, and esRAGE, as well as their combined detection of severe atherosclerosis in CHD. Results. In contrast with the control group, the level of serum CML together with sRAGE in the observation group was considerably elevated, while the level of esRAGE appeared in a downward trend ( P < 0.05). The level of serum CML and sRAGE was directly proportional to the measure of atherosclerosis in CHD, while the level of esRAGE was inversely proportional to the measure of atherosclerosis in CHD ( P < 0.05). That is to say that serum CML and sRAGE were positive in matter of the measure of atherosclerosis in CHD, while esRAGE negatively appertains to the measure of atherosclerosis in CHD ( P < 0.05). Serum CML, sRAGE, and esRAGE could effectively diagnose severe atherosclerosis in CHD, and the combined detection sensitivity (89.79%), specificity (77.16%), accuracy (86.12%), positive predictive value (86.63%), negative predictive value (88.59%), and area under ROC curve (AUC) (0.924) were higher ( P < 0.05). Conclusion. CML and sRAGE, as well as esRAGE, are bound up with the degree of atherosclerosis in CHD, which is conducive to clinical diagnosis and treatment.

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“…CHD is the major cause resulting in cardiovascular death, which presents myocardial dysfunction and ischemia induced by evident CAS. 28,29 With the increase in the severity of CAS, the incidence of atherosclerotic dysplasia and plaque burden are also increased, [30][31][32][33][34] whereas the assessment of plaque burden or composition can predict the risk of cardiovascular events. [32][33][34] miRNAs exert vital roles in the pathogenesis of CHD and atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of peripheral blood miR‐296 combined with vascular endothelial growth factor B on the degree of coronary artery stenosis in patients with coronary heart disease

Wang

et al. 2023

J of Clinical Ultrasound

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Objective Coronary heart disease (CHD) is a disorder resulting from organic and functional coronary artery stenosis (CAS), thus causing reduced oxygenated blood in the heart. miRNAs are useful biomarkers in the diagnosis of atherosclerosis, CHD, and acute coronary syndrome. Vascular endothelial growth factor (VEGF) is closely related to CHD. This study explored the correlation of miR‐296 and VEGF‐B expression levels in peripheral blood with CAS degree in CHD patients. Methods Totally 220 CHD patients were enrolled and classified into mild‐(71 cases)/moderate‐(81 cases)/severe‐CAS (68 cases) groups, with another 80 healthy cases as controls. The serum miR‐296 and VEGF‐B expression levels were detected using reverse transcription quantitative polymerase chain reaction. The correlation between miR‐296 and CAS‐related indexes was assessed via Pearson analysis. The binding relationship of miR‐296 and VEGF‐B was first predicted and their correlation was further analyzed via the Pearson method. The clinical diagnostic efficacy of miR‐296 or VEGF‐B on CAS degree was evaluated by the receiver operating characteristic curve. Results Serum miR‐296 was downregulated in CHD patients and was the lowest in patients with severe‐CAS. miR‐296 was negatively‐correlated with high‐sensitivity C‐reactive protein, brain natriuretic peptide, and cardiac troponin I. miR‐296 targeted VEGF‐B. VEGF‐B was upregulated in CHD patients and inversely‐related to miR‐296. Low expression of miR‐296 and high expression of VEGF‐B both had high clinical diagnostic values on CAS degree in CHD patients. miR‐296 combined with VEGF‐B increased the diagnostic value on CAS. Conclusion Low expression of miR‐296 combined with high expression of its target VEGF‐B predicts CAS degree in CHD patients.

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The Emerging Roles of Chromogranins and Derived Polypeptides in Atherosclerosis, Diabetes, and Coronary Heart Disease

Cited by 15 publications

References 143 publications

Selected Serum Markers Associated with Pathogenesis and Clinical Course of Type 1 Diabetes in Pediatric Patients—The Effect of Disease Duration

Selected Serum Markers Associated with Pathogenesis and Clinical Course of Type 1 Diabetes in Pediatric Patients—The Effect of Disease Duration

Correlation Analysis of CML, sRAGE, and esRAGE and the Measure of Atherosclerosis of Coronary Heart Disease

Diagnostic value of peripheral blood miR‐296 combined with vascular endothelial growth factor B on the degree of coronary artery stenosis in patients with coronary heart disease

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