Serum cartilage oligomeric matrix protein accumulation decreases significantly after 12weeks of running but not swimming and cycling training – A randomised controlled trial

Çelik, Özgür; Salci, Yasar; Ak, Emre; Kalacı, Aydıner; Korkusuz, Feza

doi:10.1016/j.knee.2012.06.001

Cited by 43 publications

(54 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean baseline serum COMP concentration was 7.5 U/l (95%CI: 6.4, 8.7) prior to running with passive orthoses and 7.6 U/l (95%CI: 6.4, 8.8) prior to running with active orthoses (Table ). The baseline values did not differ significantly and they were in accordance with levels of healthy adults recorded in other studies …”

Section: Resultssupporting

confidence: 91%

Effect of increased mechanical knee joint loading during running on the serum concentration of cartilage oligomeric matrix protein (COMP)

Firner

Willwacher

Marées

et al. 2018

Journal Orthopaedic Research

View full text Add to dashboard Cite

The purpose of the study was to investigate the effect of an increase in mechanical knee joint loading during running on the serum COMP level. On two different test days, 20 healthy men ran with knee orthoses for 30 min on a treadmill (v = 2.2 m/s). On day 1, the orthoses were passive, whereas on day 2 they were pneumatically driven (active) and thus increased the external knee flexion moments (+30.9 Nm) during stance phase. Lower-limb mechanics and serum COMP levels (baseline; 0, 0.5, 1, 2 h post running) were analyzed. COMP levels increased immediately after running with passive (+35%; pre: 7.5 U/l, 95%CI: 6.4, 8.7, post: 9.8 U/l, 95%CI: 8.8, 10.8, p < 0.001) and active orthoses (+45%; pre: 7.6 U/l; 95%CI: 6.4, 8.8, post: 10.3 U/l, 95%CI: 9.2, 11.5, p < 0.001), but they did not differ between interventions. While running with active orthoses, greater ankle dorsiflexion angles, knee flexion angles, and moments occurred (p < 0.05). Comparing both interventions, the Δ COMP pre-post, meaning the difference (Δ) between running with active and passive orthoses in pre to post COMP level change (=level after (post) running minus level before (pre) running), correlated negatively with Δ COMP baseline (difference between the baseline COMP level before running with active and passive orthoses, r = -0.616; p = 0.004), and with a positive tendence with the Δ maximum knee flexion (r = 0.388; p = 0.091). Therefore, changes in COMP concentration after physical activity seem to be highly influenced by the COMP baseline level. In addition, correlation analysis indicates that modifications in knee joint kinematics have a greater effect on cartilage metabolism than an increase in joint moments. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1937-1946, 2018.

show abstract

Section: Resultssupporting

confidence: 91%

Effect of increased mechanical knee joint loading during running on the serum concentration of cartilage oligomeric matrix protein (COMP)

Firner

Willwacher

Marées

et al. 2018

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…Taken together, these findings suggest that an acute increase in serum COMP and lubricin is a normal healthy response to exercise, but that a minimal difference exists in the response to aerobic weight bearing and aerobic nonweight bearing exercise. This exercise-induced response is in accordance with several previous studies that have also shown an increase in serum COMP following activities such as walking and running, which involve joint loading that are high in loading frequency but relatively low in loading amplitude (Mündermann et al 2005;Mündermann et al 2009;Niehoff et al 2010;Celik et al 2013;Denning et al 2015). The serum COMP response to exercise is typically greater and associated with longer recovery times, following prolonged bouts of exercise (Kim et al 2009).…”

Section: Introductionsupporting

confidence: 92%

“…Several studies have previously demonstrated that walking results in an acute increase in serum COMP (Mündermann et al 2005;Celik et al 2013;Denning et al 2016). The exact mechanism contributing to the increase in serum COMP is unknown, however it is understood to be a physiological response that reflects increased healthy cartilage turnover or metabolism, rather than cartilage degradation.…”

Section: Discussionmentioning

confidence: 99%

The effect of aerobic walking and lower body resistance exercise on serum COMP and hyaluronan, in both males and females

2018

View full text Add to dashboard Cite

show abstract

“…The ECM protein COMP is secreted by chondrocytes, synoviocytes, fibroblasts, and even osteoblasts (). Not only cartilage damage, but also physical exercise such as running, cycling, and swimming can increase serum COMP levels (). Our results showed higher serum COMP levels after injury in mice in all groups within the first 5 days, and all groups had a downward trend with a slow decline.…”

Section: Discussionmentioning

confidence: 99%

Early Response of Mouse Joint Tissue to Noninvasive Knee Injury Suggests Treatment Targets

Holguin

Silva

et al. 2014

Arthritis & Rheumatology

View full text Add to dashboard Cite

Objective Joint trauma can lead to a spectrum of acute lesions, including cartilage degradation, ligament or meniscus tears, and synovitis, all potentially associated with osteoarthritis. The goal of this study was to generate and validate a murine model of knee joint trauma following non-invasive controlled injurious compression in vivo and to investigate early molecular events. Methods The right knees of 8-week old mice were placed in a hyperflexed position and subjected to compressive joint loading at one of three peak forces (3, 6, 9 N) for 60 cycles in a single loading period and harvested at 5, 9 and 14 days post loading (n=3–5 mice for each time point and for each loading). The left knees were not loaded and served as the contralateral controls. Histological, immunohistochemical and ELISA analyses were performed to evaluate acute pathologic features in chondrocyte viability, cartilage matrix metabolism, synovial reaction, and serum COMP levels. Results Acute joint pathology was associated with increased injurious loads. All loading regimens induced chondrocyte apoptosis, cartilage matrix degradation, disruption of cartilage collagen fibril arrangement, and increased levels of serum COMP. We also observed that 6N loading induced mild synovitis by day 5 whereas at 9 N, with tearing of the anterior cruciate ligament, severe posttraumatic synovitis and ectopic cartilage formation were observed. Conclusion We have established and analyzed some early events in a murine model of knee joint trauma with different degrees of over-loading in vivo. These results suggest that immediate therapies particularly targeted to apoptosis and synovial cell proliferation could affect the acute posttraumatic reaction to potentially limit chronic consequences and osteoarthritis.

show abstract

Serum cartilage oligomeric matrix protein accumulation decreases significantly after 12weeks of running but not swimming and cycling training – A randomised controlled trial

Cited by 43 publications

References 33 publications

Effect of increased mechanical knee joint loading during running on the serum concentration of cartilage oligomeric matrix protein (COMP)

Effect of increased mechanical knee joint loading during running on the serum concentration of cartilage oligomeric matrix protein (COMP)

The effect of aerobic walking and lower body resistance exercise on serum COMP and hyaluronan, in both males and females

Early Response of Mouse Joint Tissue to Noninvasive Knee Injury Suggests Treatment Targets

Contact Info

Product

Resources

About