Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women

Abstract

Context and objective: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women. Materials and methods: Five hundred and ninety-three women with no baseline KOA underwent 5-year knee radiographs over 20-years and were asked about knee pain a month before each assessment. A repeated measures logistic regression model was used where the outcomes were recorded at 5, 10, 15 and 20-years follow-up. Results: The highest quartile of sCOMP was associated with increased risk of RKOA with overall OR of 1.97 (95% CI: 1.33–2.91) over 20 years when compared with the lowest sCOMP quartile. The association with painful KOA was similar and also independent, but only when the fourth and third sCOMP quartiles were compared. Discussion and conclusion: This study demonstrates that sCOMP levels are predictive of subsequent structural changes and incidence of painful KOA, independently of age and BMI.

Value of Biomarkers in Osteoarthritis

“…Researchers have come up with studies that examine large OA cohorts dealing with the predictive ability of established OA biomarkers [66,67]. In one of these studies, the sHA was associated with the joint space width (JSW) in the Iwaki Health Promotion Project over a period of 5 years [66].…”

“…In a Chingford cohort study [67] with a 20-year data history of radiographic knee OA progression in a group of middle-aged women with a Kellgren and Lawrence (KL) score of 0 at baseline, the high sCOMP levels were significantly related to painful radiographic OA development in the knee. The increase in the risk of radiographic knee OA was found in relation to sCOMP during the 5-year follow-up of 493 cases.…”

“…Both biomarkers showed negative correlation with knee OA. The authors suggested that the low cartilage and subchondral bone turnover in the earliest stages of knee OA may explain this second finding [67].…”

Osteoarthritis Year in Review 2016: biomarkers (biochemical markers)

“…In one of these studies, sHA was associated with JSW over a 5 year period in the Iwaki Health Promotion Project 50 . In the Chingford cohort study, which has 20 years of data on development of radiographic knee OA progression in a cohort of middle-aged women with Kellgren and Lawrence (KL) scores of zero at baseline, sCOMP levels in the highest quartile were significantly associated with the development of radiographic knee OA and painful radiographic knee OA 51 . sCOMP was also shown to be associated with increased 5-year risk of radiographic knee OA when tested in 493 subjects with knee OA 51 .…”

“…In the Chingford cohort study, which has 20 years of data on development of radiographic knee OA progression in a cohort of middle-aged women with Kellgren and Lawrence (KL) scores of zero at baseline, sCOMP levels in the highest quartile were significantly associated with the development of radiographic knee OA and painful radiographic knee OA 51 . sCOMP was also shown to be associated with increased 5-year risk of radiographic knee OA when tested in 493 subjects with knee OA 51 . In the third report, 5-year data from the Rotterdam study cohort was used to examine biomarker associations with incidence of OA and KL progression 53 .…”