Osteoarthritis Year in Review 2016: biomarkers (biochemical markers)

Mobasheri, Ali; Bay‐Jensen, Anne‐Christine; Spil, W.E. van; Larkin, J.; Levesque, Marc C.

doi:10.1016/j.joca.2016.12.016

Cited by 129 publications

(92 citation statements)

References 80 publications

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“…Protein targets proposed to generate the antibody bead arrays were selected based on thorough mining of experimental evidence in the literature of rheumatic diseases 36–38 and in previous in-house efforts in the field of osteoarthritis using mass spectrometry analyses 24, 28, 39 . The antibody set was finally designed according to the antibody availability within the Human Protein Atlas (HPA) 40 .…”

Section: Methodsmentioning

confidence: 99%

Discovery of circulating proteins associated to knee radiographic osteoarthritis

Lourido

Ayoglu

Fernández‐Tajes

et al. 2017

Sci Rep

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Currently there are no sufficiently sensitive biomarkers able to reflect changes in joint remodelling during osteoarthritis (OA). In this work, we took an affinity proteomic approach to profile serum samples for proteins that could serve as indicators for the diagnosis of radiographic knee OA. Antibody suspension bead arrays were applied to analyze serum samples from patients with OA (n = 273), control subjects (n = 76) and patients with rheumatoid arthritis (RA, n = 244). For verification, a focused bead array was built and applied to an independent set of serum samples from patients with OA (n = 188), control individuals (n = 83) and RA (n = 168) patients. A linear regression analysis adjusting for sex, age and body mass index (BMI) revealed that three proteins were significantly elevated (P < 0.05) in serum from OA patients compared to controls: C3, ITIH1 and S100A6. A panel consisting of these three proteins had an area under the curve of 0.82 for the classification of OA and control samples. Moreover, C3 and ITIH1 levels were also found to be significantly elevated (P < 0.05) in OA patients compared to RA patients. Upon validation in additional study sets, the alterations of these three candidate serum biomarker proteins could support the diagnosis of radiographic knee OA.

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Section: Methodsmentioning

confidence: 99%

Discovery of circulating proteins associated to knee radiographic osteoarthritis

Lourido

Ayoglu

Fernández‐Tajes

et al. 2017

Sci Rep

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“…These include predictive markers, target occupancy markers and pharmacodynamic or target engagement markers. Although predictive biomarkers may be of greatest use in a clinical trial, prognostic biomarkers will also play a part, and much of the work done to date by others has been in the prognostic biomarker category 149 . For example, in regard to osteoarthritis, many inflammatory biomarkers have been associated with disease progression.…”

Section: Therapeutic Considerations and Challengesmentioning

confidence: 99%

Senescent cells: an emerging target for diseases of ageing

Childs

Gluscevic

Baker

et al. 2017

Nat Rev Drug Discov

905

797

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Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.

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“…These factors show remarkable similarity to those found in AC, including MMP 1‐3 and 7‐14, although their expression levels may differ from those in the NP (see Table ). Additionally, the ECM in the NP and AC is also cleaved by ADAMTSs 4 and 5 …”

Section: Degeneration In the Human Intervertebral Disc And Articular mentioning

confidence: 99%

Osteoarthritis and intervertebral disc degeneration: Quite different, quite similar

et al. 2018

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Intervertebral disc degeneration describes the vicious cycle of the deterioration of intervertebral discs and can eventually result in degenerative disc disease (DDD), which is accompanied by low‐back pain, the musculoskeletal disorder with the largest socioeconomic impact world‐wide. In more severe stages, intervertebral disc degeneration is accompanied by loss of joint space, subchondral sclerosis, and osteophytes, similar to osteoarthritis (OA) in the articular joint. Inspired by this resemblance, we investigated the analogy between human intervertebral discs and articular joints. Although embryonic origin and anatomy suggest substantial differences between the two types of joint, some features of cell physiology and extracellular matrix in the nucleus pulposus and articular cartilage share numerous parallels. Moreover, there are great similarities in the response to mechanical loading and the matrix‐degrading factors involved in the cascade of degeneration in both tissues. This suggests that the local environment of the cell is more important to its behavior than embryonic origin. Nevertheless, OA is widely regarded as a true disease, while intervertebral disc degeneration is often regarded as a radiological finding and DDD is undervalued as a cause of chronic low‐back pain by clinicians, patients and society. Emphasizing the similarities rather than the differences between the two diseases may create more awareness in the clinic, improve diagnostics in DDD, and provide cross‐fertilization of clinicians and scientists involved in both intervertebral disc degeneration and OA.

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Osteoarthritis Year in Review 2016: biomarkers (biochemical markers)

Cited by 129 publications

References 80 publications

Discovery of circulating proteins associated to knee radiographic osteoarthritis

Discovery of circulating proteins associated to knee radiographic osteoarthritis

Senescent cells: an emerging target for diseases of ageing

Osteoarthritis and intervertebral disc degeneration: Quite different, quite similar

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