Serum Cardiovascular Risk Factors in Obstructive Sleep Apnea

Çan, Murat; Açıkgöz, Şerefden; Mungan, Görkem; Bayraktaroğlu, Taner; Koçak, Erdem; Güven, Berrak; Demırtaş, Selda

doi:10.1378/chest.129.2.233

Cited by 127 publications

(89 citation statements)

References 31 publications

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“…19,20 Many cross-sectional, case-control, and non-randomized interventional studies have suggested that the levels of the pro-inflammatory cytokines and C-reactive protein are elevated in OSA patients. 21,22 These results have not been consistent, however, as contradictory findings have been reported in studies by both our group and others, in which this association was attributed mainly to obesity. 23,24 Furthermore, obese patients are resistant to leptin, which mainly serves to regulate appetite and energy expenditure.…”

Section: Discussioncontrasting

confidence: 89%

Impact of OSA on Biological Markers in Morbid Obesity and Metabolic Syndrome

Salord¹,

Gasa

Mayos³

et al. 2014

Journal of Clinical Sleep Medicine

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Section: Discussioncontrasting

confidence: 89%

Impact of OSA on Biological Markers in Morbid Obesity and Metabolic Syndrome

Salord¹,

Gasa

Mayos³

et al. 2014

Journal of Clinical Sleep Medicine

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“…Data were analyzed using a semi-automatic system (Rembrandt; Medcare Flaga). Arterial oxygen saturation using pulse oximetry and AHI were measured as described 2 . Patients with OSAS whose AHI was ≥ 20 events/hour were prescribed nCPAP (PV10; Breas, Sweden), and the effects of nCPAP were confirmed by polysomnography or by monitoring arterial oxygen saturation while asleep.…”

Section: Methodsmentioning

confidence: 99%

Effect of Nasal Continuous Positive Airway Pressure in Men on Global Left Ventricular Myocardial Performance in Patients With Obstructive Sleep Apnea Syndrome

Koga

Ikeda

Urata

et al. 2008

The American Journal of Cardiology

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The influence of obstructive sleep apnea syndrome (OSAS) on left ventricular function remains controversial. We examined the influence of OSAS on global left ventricular function using the myocardial performance index (Tei-index) and plasma brain natriuretic peptide (BNP) level, and investigated the effect of nasal continuous positive airway pressure (nCPAP) on these parameters. We obtained echocardiographic indices including the Tei-index and BNP concentrations from 27 patients with OSAS whose mean apnea-hypopnea index (AHI) was 42.2 ± 21.5 events/hour and who were undergoing nCPAP, as well as from 22 control individuals. We defined global left ventricular dysfunction (GLVD) as a Tei-index of ≥ 0.50, and high BNP as ≥ 20 pg/ml. Compared with controls, the Tei-index of OSAS patients was significantly increased (P < 0.01) and the prevalence of GLVD was high (19%, P < 0.05). The correlation between the Tei-index and AHI was significant (r = 0.447, P < 0.05). Although BNP levels were higher in OSAS patients than in controls, the difference did not reach significance. The BNP level was high in 37% of OSAS patients and in only 9% of controls (P < 0.05). The Tei-index of OSAS patients was significantly decreased after 1 and 3 months of nCPAP (P < 0.01), and the prevalence of GLVD significantly decreased from 19% to 4% (P < 0.05). In contrast, BNP significantly decreased at 3 months after nCPAP (P < 0.05). In conclusion, patients with moderate to severe OSAS frequently have impaired global left ventricular myocardial performance, which can be reversed at the early stage after starting nCPAP.

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“…Low grade systemic inflammation may be a possible mechanism linking OSA to cardiovascular disease. Prior studies examining the association between OSA and CRP levels have produced conflicting results, with some studies verifying an independent association with disease severity (36)(37)(38)(39)(40)(41)(42)(43)(44)(45) and others showing no relationship (46)(47)(48)(49)(50)(51). Potential limitations of previous work are the confounding effects of obesity and medical comorbidity.…”

Section: Sleep Apnea and Inflammationmentioning

confidence: 99%