Impact of OSA on Biological Markers in Morbid Obesity and Metabolic Syndrome

Effects of CPAP therapy on visceral fat thickness, carotid intima‐media thickness and adipokines in patients with obstructive sleep apnoea

“…Continuous positive airway pressure (CPAP), the effective treatment of OSA, is thus considered to be an important modality for reducing cardiometabolic risk, although the evidence is controversial owing to different study designs and the presence of major confounders. Various studies evaluating CPAP therapy on visceral fat, intima‐media thickness (IMT) and various adipokines have not led to definite conclusions . We performed a randomized controlled trial comparing the effects of therapeutic versus subtherapeutic CPAP on visceral fat thickness, carotid IMT and levels of adipokines in patients with newly diagnosed OSA.…”

“…Various studies evaluating CPAP therapy on visceral fat, intima-media thickness (IMT) and various adipokines have not led to definite conclusions. [7][8][9] We performed a randomized controlled trial comparing the effects of therapeutic versus subtherapeutic CPAP on visceral fat thickness, carotid IMT and levels of adipokines in patients with newly diagnosed OSA.…”

Commentary: Stress Signal Network between Hypoxia and ER Stress in Chronic Kidney Disease

“…It is characterized by increased upper airway resistance and intermittent breathing pauses during sleep, leading to oxygen desaturation and sleep fragmentation (Epstein et al, 2009). Due mainly to intermittent hypoxia-related mechanisms, OSA has been associated with increased oxidative stress (Lavie, 2015) and inflammation (Zhang et al, 2014), which in turn may become potentially harmful to various tissues and organs (Anandam et al, 2013; Salord et al, 2014). …”

Obstructive sleep apnea and acute respiratory failure: An analysis of mortality risk in patients with pneumonia requiring invasive mechanical ventilation

“…Persons with untreated OSA are at increased risk for metabolic dysfunction [1], pulmonary hypertension [2], arrhythmias [3], and cardiovascular disease [4].Currently, there is limited data on the effects of OSA on mortality related to pulmonary disease [5,6].…”