Serum Cardiac Troponin I Concentrations in Cattle with Cardiac and Noncardiac Disorders

Abstract

Background: Making a clinical diagnosis of pericarditis in cattle is difficult and additional diagnostic tests are needed to evaluate cattle with suspected pericarditis. Serum cardiac troponin I (cTnI) concentrations are increased in cattle with pericarditis, but the utility of measuring serum cTnI concentrations in cattle with suspected pericarditis in cattle remains unclear.Objectives: To determine if serum cTnI concentrations in cattle can be used to differentiate pericarditis from other cardiac disorders and noncardiac thoracic diseases.Animals: Seventy‐seven clinically diseased cattle and 19 healthy control cattle.Methods: Serum cTnI concentrations were measured using an Immunlite Troponin I immunometric chemiluminescent assay in consecutive cases of postmortem‐confirmed pericarditis (n = 18), endocarditis (n = 15), chronic suppurative pneumonia (n = 13), congenital heart disease (n = 10), reticulitis (n = 3), mediastinal abscess (n = 7), thymic lymphoma (n = 6), and caudal vena cava thrombosis (n = 5). Serum cTnI concentrations were measured in 19 healthy cattle.Results: Although serum cTnI concentrations were significantly higher in cattle with pericarditis compared with healthy cattle, they were not significantly different from concentrations in cattle with endocarditis, congenital cardiac disease, mediastinal abscess, reticulitis, caudal vena cava thrombosis, or chronic suppurative pneumonia.Conclusions: Serum cTnI cannot be used to distinguish cattle with pericarditis from cattle with other primary cardiac diseases. In addition, serum cTnI concentrations cannot distinguish between cattle with primary cardiac diseases and those with other noncardiac, intrathoracic disorders.

Cardiac biomarkers in premature calves with respiratory distress syndrome

“…Cardiac injury in cattle has been identified by increased cardiac troponin levels in a variety of diseases that include monensin toxicosis (Varga et al, 2009), traumatic reticulopericarditis (Gunes et al, 2008;Mellanby et al, 2009), footand-mouth disease (Gunes et al, 2005;Karapinar et al, 2010), and endotoxaemia (Peek et al, 2008). The cardiospecific isoenzyme troponin I provides the most sensitive and specific indication of cardiac necrosis whereas the predictive value of serum CK and LDH activities is much lower (Radostits et al, 2007).…”

Assessment of Blood Concentration of Cardiac Troponin I (cTnI) in Healthy Calves and Stocker Calves Effected with Bovine Respiratory Disease Complex

“…Several recently published studies have reported blood cTn I concentration from cattle having cardiac and non-cardiac intra-thoracic diseases [23][24][25][26][27]31]. These reports included pericarditis, endocarditis, congenital heart disease, monensin toxicity, endotoxemia, reticulitis, mediastinal abscess, thymic lymphoma, caudal vena cava thrombosis, and chronic suppurative pneumonia.…”

Troponina, biomarcador de injuria cardiaca, en medicina veterinaria: Revisión

“…Elevações nas concentrações séricas foram menores em quadros de arritmias causadas por lesões miocárdicas secundárias (Nath et al, 2012). Lesões isquêmicas crônicas induzidas no miocárdio de ovinos igualmente resultaram elevações de cTnI, Em bovinos, Mellanby et al (2009) verificaram o aumento sérico da cTnI em casos de pericardite e embora tenha indicado lesão miocárdica não permitiu a confirmação da etiologia.…”