Serum Cardiac Troponin I Concentration in Dogs with Precapillary and Postcapillary Pulmonary Hypertension

Guglielmini, Carlo; Civitella, Carla; Diana, Alessia; Tommaso, Morena Di; Cipone, Mario; Luciani, A

doi:10.1111/j.1939-1676.2009.0430.x

Cited by 47 publications

(58 citation statements)

References 58 publications

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“…Cardiac TnI is elevated in dogs with both precapillary and post-capillary PH and is mildly positively correlated with PAP and with echocardiographic indices of atrioventricular dilation [11]; although, in another study on dogs with pre-capillary PH cardiac TnI did not correlate with PAP [76]. These confl icting results may be attributable to differences in patient population or underlying disease.…”

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confidence: 39%

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Pulmonary Hypertension in the Dog

Poser

Guglielmini

2016

Acta Veterinaria

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Canine pulmonary hypertension is a clinical condition that needs to be adequately investigated and recognised because of the lack of specifi c clinical signs, the potential for rapid and irreversible deterioration of pulmonary vascular function and the development of right-sided heart failure. In recent years, many studies have been published on pulmonary hypertension, improving the understanding of its pathophysiology, the accuracy of diagnostic tests and the management of affected patients. This article provides updated information on pulmonary hypertension and serves as a resource for veterinarians regarding the interpretation of diagnostic tests and the clinical management of affected dogs.

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contrasting

confidence: 39%

“…In veterinary medicine, a similar classifi cation system has not been developed, and canine PH is often reported as a primary or secondary condition [9,10] or, according to the haemodynamic pathophysiologic mechanism, as pre-capillary or post-capillary [11].…”

Section: Classification Of Pulmonary Hypertensionmentioning

confidence: 99%

Pulmonary Hypertension in the Dog

Poser

Guglielmini

2016

Acta Veterinaria

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“…Several studies in human and veterinary medicine have demonstrated that serum cardiac troponin concentrations are increased in various cardiac and noncardiac diseases 4, 19, 30, 33, 38, 44, 45…”

Section: Discussionmentioning

confidence: 99%

Serum Cardiac Troponin I Concentrations in Dogs with Systemic Inflammatory Response Syndrome

Hamacher¹,

Dörfelt²,

Müller³

et al. 2015

Veterinary Internal Medicne

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BackgroundMyocardial injury can be detected by cardiac troponin I (cTnI) concentration, which appears to be a predictor of short‐term death in critically ill patients. It is unknown if the best prognostic indicator of short‐term survival is cTnI measurement at admission or at later time points.Hypothesis/ObjectivesMeasuring cTnI with a high‐sensitivity (HS) test at different time points after admission may be a better short‐term prognostic indicator than a single cTnI measurement at admission in dogs with systemic inflammatory response syndrome (SIRS).AnimalsProspective, observational clinical study of 60 dogs with SIRS.MethodsCardiac troponin I concentration was measured in 133 serum samples, collected at days 1, 2, 3, and 5. Additionally, the acute patient physiologic and laboratory evaluation (APPLE) fast score was evaluated at admission. Prognostic capabilities of cTnI measurement and APPLE fast score for 28‐day mortality were assessed by receiver operating characteristic curve analysis.ResultsForty‐one dogs with SIRS that survived 28 days had significantly lower serum cTnI concentrations at admission (median, 0.09 ng/mL; P = .004) and at the peak time point (median, 0.23 ng/mL; P = .01) compared to 19 nonsurvivors (median at admission, 0.63 ng/mL; median at peak, 1.22 ng/mL). Area under the curve to predict survival, using cTnI was similar at admission (0.732) and at peak (0.708), and was 0.754 for the APPLE fast score.Conclusions and Clinical ImportanceIncreased cTnI concentration in dogs with SIRS is associated with poor outcome. Daily follow‐up measurement of cTnI concentration provides no additional prognostic information for short‐term mortality.

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“…PH has been reported in dogs to be associated with respiratory disorders, HWD and CDMD, with incidences ranging from 8% to 50%, 1% to 6%, and 30% to 74%, respectively (Johnson et al 1999;Pyle et al 2004;Kellum and Stepien 2007;Serres et al 2007;Guglielmini et al 2010). CDMD was the most common cause among the three causes of PH in this study.…”

Section: Discussionmentioning

confidence: 73%

Echocardiographic assessment of right heart indices in dogs with elevated pulmonary artery pressure associated with chronic respiratory disorders, heartworm disease, and chronic degenerative mitral valvular disease

Tai¹,

Huang²

2013

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to evaluate right ventricular (RV) remodeling and right heart failure associated with different causes of elevated pulmonary arterial pressure (PAP) in dogs. In total, 169 client-owned dogs with tricuspid regurgitation (TR) and 40 client-owned clinically healthy dogs were included. Dogs with TR were further categorised as suffering from chronic respiratory disorders (CRD), heartworm disease (HWD), mild/ moderate chronic degenerative mitral valvular disease (CDMD), and severe CDMD. Among the echocardiographic indices of the right heart, no significant difference in the tricuspid annular plane systolic excursion to aortic root diameter ratio was found among the clinical healthy controls and the four different TR categories. No significant differences in TR peak velocity and pulmonic regurgitation peak velocity were found among dogs in the four different TR categories. The ratio of the right to left ventricular basal diameter in the right ventricular-focused view was significantly higher in dogs with chronic respiratory disorders and dogs with heartworms. Left ventricular compression quantified using the eccentricity index and the ratio of the main pulmonary artery to aortic root diameter were significantly higher in dogs with HWD. Their right ventricular acceleration to ejection time (AT/ET) was significantly lower in dogs with HWD. Based on these findings, we conclude that right heart indices are affected by CRD, HWD, and moderate to severe CDMD. However, right heart indices derived from left heart measurements might be underestimated in dogs with CDMD.Keywords: left ventricular eccentricity indices; mean electrical axis; pulmonary hypertension; right heart remodelling; tricuspid annular plane systolic excursion List of abbreviationsAo = aortic root diameter, AT = acceleration time, CDMD = chronic degenerative mitral valvular disease, CRD = chronic respiratory disorders, CV = coefficient of variation, ECG = electrocardiography, ET = ejection time, HWD = heartworm disease, LA/Ao = left atrial/aortic root ratio, LVD = left ventricular basal diameter, LV-EI = left ventricular eccentricity index, MEA = mean electrical axis, MPA = main pulmonary artery, PAP = pulmonary arterial pressure, PH = pulmonary hypertension, PR = pulmonic valve regurgitation, RVD = right ventricular basal diameter, SBP = systemic blood pressure, SD = standard deviation, TAPSE = tricuspid annular plane systolic excursion, TR = tricuspid regurgitation, VHS = vertebral heart scale Pulmonary hypertension (PH) is defined by high diastolic or systolic PAP and may lead to right ventricular concentric or eccentric hypertrophy, right atrial enlargement, and right-sided heart failure (Serres et al. 2006). High PAP values above the reference range indicate PH, which can result from pre-and post-capillary haemodynamic changes (Kellihan and Stepien 2012). PH is a wellrecognised clinical condition in human patients and can be primary or secondary to various diseases of the pulmonary vasculature (Galie et al. 2009). Primar...

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Serum Cardiac Troponin I Concentration in Dogs with Precapillary and Postcapillary Pulmonary Hypertension

Cited by 47 publications

References 58 publications

Pulmonary Hypertension in the Dog

Pulmonary Hypertension in the Dog

Serum Cardiac Troponin I Concentrations in Dogs with Systemic Inflammatory Response Syndrome

Echocardiographic assessment of right heart indices in dogs with elevated pulmonary artery pressure associated with chronic respiratory disorders, heartworm disease, and chronic degenerative mitral valvular disease

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