Serum carbohydrate antigen 19-9 and prognosis of patients with gastric cancer

Xiao, Jiuchang; He, Xiaoyan; Wang, Zengyan; Hu, Jiying; Sun, Fang; Feng, Qi; Yang, Shugang; Zhang, Xiao

doi:10.1007/s13277-013-1177-1

Cited by 26 publications

(16 citation statements)

References 20 publications

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“…However, Kodera et al (Kodera et al, 1996) revealed that serum CA 19-9 was better than CEA as a prognostic factor in multivariate analyses in gastric cancer patients. A meta-analysis performed by Xiao et al (Xiao et al, 2014) showed that elevated serum CA 19-9 levels were associated with poorer overall survival in patients with gastric cancer. In our study, the univariate analysis indicated that there was a significant difference in 5-year survival between positive and negative cases for each of the four markers examined.…”

Section: Discussionmentioning

confidence: 99%

Combined Detection of CEA, CA 19-9, CA 242 and CA 50 in the Diagnosis and Prognosis of Resectable Gastric Cancer

Tian¹,

Yu²,

Kang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Combined Detection of CEA, CA 19-9, CA 242 and CA 50 in the Diagnosis and Prognosis of Resectable Gastric Cancer

Tian¹,

Yu²,

Kang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…A variety of factors have been recognized as prognostic factors for early gastric cancer, including tumor size, differentiation status, tumor depth, LNM and vessel involvement [ 7 ]. In addition, tumor markers including CEA [ 8 ], CA19–9 [ 9 ], and AFP [ 10 ] were demonstrated to be prognostic factors for gastric cancer. However, prognostic significance of these markers for early gastric cancer have not been investigated yet.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic value of CEA, CA19–9, AFP and CA125 for early gastric cancer

et al. 2017

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BackgroundThe diagnostic and prognostic significance of carcinoembryonic antigen (CEA), carbohydrate associated antigen 19–9 (CA19–9), alpha-fetoprotein (AFP) and cancer antigen 125 (CA125) in early gastric cancer have not been investigated yet. Thus, the present study aimed to explore the diagnostic and prognostic significance of the four tumor markers for early gastric cancer.MethodsFrom September 2008 to March 2015, 587 early gastric cancer patients were given radical gastrectomy in our center. The clinicopathological characteristics were recorded. The association between levels of CEA and CA19–9 and clinicopathological characteristics and prognosis of patients were analyzed.ResultsThere were 444 men (75.6%) and 143 women (24.4%). The median age was 57 years (ranged 21–85). The 1-, 3- and 5-year overall survival rate was 99.1%, 96.8% and 93.1%, respectively. The positive rate of CEA, CA19–9, AFP and CA125 was 4.3%, 4.8%, 1.5% and 1.9%, respectively. The positive rate of all markers combined was 10.4%. The associations between the clinicopathological features and levels of CEA and CA19–9 were analyzed. No significant association was found between CEA level and clinicopathological features. However, elevated CA19–9 level was correlated with female gender and presence of lymph node metastasis. Age > 60 years old, presence of lymph node metastasis and elevation of CEA level were independent risk factors for poor prognosis of early gastric cancer.ConclusionsThe positive rates of CEA, CA19–9, APF and CA125 were relatively low for early gastric cancer. Elevation of CA19–9 level was associated with female gender and presence of lymph node metastasis. Elevation of CEA level was an independent risk factor for the poor prognosis of early gastric cancer.

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“…A variety of factors are well recognized as prognostic indicators for gastric cancer, including tumor size, tumor depth, lymph node metastasis (LNM), and vessel involvement [ 3 , 4 ]. In addition, elevated levels of preoperative tumor markers, including CEA [ 5 ], CA19-9 [ 6 ], AFP [ 7 ], and CA125 [ 8 ], were demonstrated to be associated with gastric cancer prognosis. However, the prognostic values of these tumor markers within the normal range have not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Prognostic values of normal preoperative serum cancer markers for gastric cancer

et al. 2016

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We examined the prognostic value of normal levels of four serum cancer markers, carcinoembryonic antigen (CEA), carbohydrate associated antigen (CA19-9), alpha-fetoprotein (AFP) and cancer antigen 125 (CA125), in gastric cancer patients. Among 1927 gastric cancer patients enrolled in this study, 1477 were male (76.6%) and 450 were female (23.4%). The median age was 57 years (range 20-86). Clinicopathological features and survival times were recorded, and the association between CEA, CA19-9, AFP, and CA125 levels and patient prognosis was analyzed. The optimal cut-off values were 0.71 for CEA (P=0.317), 9.22 for CA19-9 (P=0.009), 3.76 for AFP (P=0.008) and 15.65 for CA125 (P=0.006). Serum CA19-9 levels correlated with gender, age, and tumor depth (all P<0.05); AFP levels correlated with pathological type (P=0.005); and CA125 levels correlated with gender, tumor size, pathological type, tumor depth and lymph node metastasis (all P<0.05). Relatively high levels of CA19-9, AFP and CA125, still within the normal range, were all associated with poor prognosis (5-year overall survival: 70.6% vs 64.2%, P<0.001. 69.6% vs 54.5%, P=0.011. 70.2% vs 54.9%, P<0.001). However, only CA19-9 and AFP levels were independent prognostic predictors. We conclude that the combined assessment of CA19-9, AFP and CA125 levels could have prognostic value in gastric cancer (P<0.001).

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Serum carbohydrate antigen 19-9 and prognosis of patients with gastric cancer

Cited by 26 publications

References 20 publications

Combined Detection of CEA, CA 19-9, CA 242 and CA 50 in the Diagnosis and Prognosis of Resectable Gastric Cancer

Combined Detection of CEA, CA 19-9, CA 242 and CA 50 in the Diagnosis and Prognosis of Resectable Gastric Cancer

Diagnostic and prognostic value of CEA, CA19–9, AFP and CA125 for early gastric cancer

Prognostic values of normal preoperative serum cancer markers for gastric cancer

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