Prognostic values of normal preoperative serum cancer markers for gastric cancer

Feng, Fan; Sun, Li; Liu, Zhen; Liu, Shushang; Zheng, Gaozan; Xu, Guanghui; Guo, Man; Lian, Xiao; Fan, Daiming; Zhang, Hongwei

doi:10.18632/oncotarget.11248

Cited by 20 publications

(12 citation statements)

References 21 publications

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“…For screening GC, several non-invasive biomarkers (tumor markers) such as CEA, CA125, and CA19-9 have been widely used for the diagnosis of GC [ 23 ]. However, sensitivities of individual or combined tumor markers with different cut-off values are reported to be as low as 4.7 – 47.7% [ 2 , 24 – 26 ].…”

Section: Discussionmentioning

confidence: 99%

Natural killer cell activity for IFN-gamma production as a supportive diagnostic marker for gastric cancer

et al. 2017

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Background/AimDecreased Natural killer cell activity (NKA) for interferon-gamma production (NKA-IFNγ) has been reported in cancer patients. The aim of this study was to determine the diagnostic performance of NKA-IFNγ for gastric cancer (GC).ResultsNKA-IFNγ levels were decreased in 261 GC patients with all stages of tumor compared to those in 48 healthy donors (P < 0.001), and lower levels of NKA-IFNγ were associated with higher GC stages. NKA-IFNγ levels were also associated with clinicopathological parameters including tumor size, depth of invasion, and lymph node metastasis. NKA-INFγ assay had better diagnostic value (AUC = 0.822) compared to serum CEA (0.624) or CA19-9 assay (0.566) (P < 0.001). Using different cut-off levels, serum CEA and CA19-9 showed sensitivities of 6.1-14.2% and 4.2-28.0%, respectively, which were much lower than that of NKA-IFNγ (55.6-66.7%).MethodsThis study included 261 patients with newly diagnosed GC and 48 healthy donors. NKA for IFNγ was determined by enzyme immunoassay after incubation of whole blood, and diagnostic performance was evaluated.ConclusionsNK cell activities for IFNγ production could be used as a supportive non-invasive tumor marker for GC diagnosis.

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Section: Discussionmentioning

confidence: 99%

Natural killer cell activity for IFN-gamma production as a supportive diagnostic marker for gastric cancer

et al. 2017

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“…The cut-off values for serum CEA were 5 ng/mL, according to the manufacturer's instructions. [ 5 ] Levels beyond the cut-off value were considered as positive.…”

Section: Methodsmentioning

confidence: 99%

Blood type AB predicts promising prognosis in gastric cancer patients with positive preoperative serum CEA

Xiao

Feng²,

Sun³

et al. 2017

Medicine

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Little is known about association between ABO blood groups and tumor markers in gastric cancer (GC) patients. The aim of the present study was to assess the prognostic value of ABO blood groups in GC patients with different levels of preoperative serum carcinoembryonic antigen (CEA).From September 2008 to April 2015, a total of 3234 GC patients who received radical gastrectomy were retrospectively analyzed. The clinicopathological characteristics including ABO blood groups and preoperative CEA were recorded. The prognostic value of ABO blood groups within different levels of serum CEA was analyzed.Overall, the ratio of male to female patients was 3.5:1; the median age was 57.4 years (range 20–87). The median overall survival (OS) for GC patients with blood type A, B, AB, and O were 52.6, 52.8, 53.8, and 53.6 months, respectively. There was no significant difference for the survival of patients among the 4 groups (P = .736). Also, no significant difference was found among the OS of the 4 blood types with negative (P = .875) and positive (P = .131) preoperative serum CEA. Further, we found that the OS of patients with positive preoperative serum CEA and blood type AB was significantly higher than that with blood type non-AB (P = .026). For patients with positive preoperative serum CEA, multivariate analysis showed that ABO blood groups were an independent prognostic factor.Blood type AB was a favorable prognostic factor for GC patients with positive preoperative serum CEA.

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“…Unfortunately, GC is difficult to diagnose at an early stage. Therefore, people are very interested in finding prognostic markers for these potentially curable patients [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer

Yang¹

2020

Med Oncol

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Gastric cancer (GC) is one of the most common malignant tumors in the world, and it is also the third largest cause of cancerrelated death in the world. As far as we know, no biomarker has been widely accepted for early diagnosis and prognosis prediction of gastric cancer. The purpose of this study is to find potential biomarkers to predict the prognosis of GC. The gene expression profiles of GSE2685 were downloaded from GEO database. Morpheus was used to calculate the differentially expressed genes (DEGs) between primary advanced gastric cancer tissues and noncancerous gastric tissues. The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analyses were performed, and protein-protein interaction (PPI) network of DEGs was constructed. Kaplan-Meier Plotter was used to determine the overall survival (OS) outcomes of UC5AC, MUC1, KRT7, GAPDH, CD44, and GEPIA was used to determine the Pearson correlation analysis. In total, 710 DEGs were identified in GC, including 396 upregulated genes and 314 downregulated genes. GO enrichment revealed that they were mainly enriched in binding, catalytic activity, cellular process and cell. KEGG pathway revealed that they were mainly enriched in metabolic pathways, pathways in cancer and PI3K-Akt signaling pathway. MUC5AC, MUC1, KRT7, GAPDH, CD44 were identified from the PPI network. MUC5AC, MUC1, KRT7, GAPDH, CD44 were demonstrated to have prognostic value for patients with GC. MUC5AC, MUC1 exhibited low expression levels in GC tissues, KRT7, GAPDH, CD44 presented high expression levels in GC tissues. In particular, KRT7 is hardly expressed in normal gastric tissues. MUC5AC and MUC1 were negatively correlated with GAPDH, CD44, respectively; and GAPDH was positively correlated with CD44 and KRT7, respectively. Moreover. MUC5AC, MUC1, KRT7, GAPDH, and CD44 are not only related to GC but also to apoptosis pathway. Results from the present study suggested that MUC5AC, MUC1, KRT7, GAPDH, CD44 may represent novel prognostic biomarkers for GC.

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Prognostic values of normal preoperative serum cancer markers for gastric cancer

Cited by 20 publications

References 21 publications

Natural killer cell activity for IFN-gamma production as a supportive diagnostic marker for gastric cancer

Natural killer cell activity for IFN-gamma production as a supportive diagnostic marker for gastric cancer

Blood type AB predicts promising prognosis in gastric cancer patients with positive preoperative serum CEA

Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer

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