2012
DOI: 10.1007/s10552-012-0015-x
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Serum calcium and incident and fatal prostate cancer in the Swedish AMORIS study

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Cited by 19 publications
(17 citation statements)
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References 27 publications
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“…However, there was a significant positive association between albumin-adjusted serum calcium and the risk of "aggressive prostate cancers" (N ¼ 579), defined as fatal cancers that occurred within 2 years following diagnosis (16). These findings are consistent with our conclusion of a time-dependent association between serum calcium and the risk of fatal prostate cancer.…”
Section: Discussionsupporting
confidence: 88%
“…However, there was a significant positive association between albumin-adjusted serum calcium and the risk of "aggressive prostate cancers" (N ¼ 579), defined as fatal cancers that occurred within 2 years following diagnosis (16). These findings are consistent with our conclusion of a time-dependent association between serum calcium and the risk of fatal prostate cancer.…”
Section: Discussionsupporting
confidence: 88%
“…In the current study, the U-shaped association for SHBG was in particular observed for men aged 20 to 40 years and non-Hispanic white men, but there was also a statistically significant but different pattern in Mexican American men. This U-shaped pattern between levels of SHBG and serum calcium is also consistent with the U-shaped pattern for serum levels of calcium and risk of prostate cancer previously found (8). A modifying effect of race/ethnicity was also observed for the association between free estradiol and serum calcium.…”
Section: Discussionsupporting
confidence: 91%
“…Several epidemiological studies also assessed the link between serum levels of calcium and risk of prostate cancer (34, 67). Moreover, a study by Berry and colleagues showed that androgens modulate calcium through the direct regulation of the STIM1 gene by androgen receptor binding to the STIM1 promoter (15).…”
Section: Discussionmentioning
confidence: 99%
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“…4) For prostate cancer, there were two large Swedish studies. The AMORIS study, with 6,353 incident cases, showed a weak negative association between serum calcium levels and prostate cancer [19], whereas in the Malmø Preventive Project, this association was only seen in young overweight men [20]. 5) For breast cancer, there was an inverse connection with serum calcium [21], as well as no association with serum calcium.…”
Section: Discussionmentioning
confidence: 99%