Serum C peptide level and renal function in diabetes mellitus

Abstract

C peptide is an active peptide hormone with potentially important physiological effects. C peptide has the capacity to diminish glomerular hyperfiltration and reduce urinary albumin excretion in both experimental and human type 1 diabetes. The present study is aimed at correlating the serum C peptide level with that of renal clearance, urinary albumin excretion and duration of diabetes. This is a prospective cross sectional study. Patients with diagnosis of type 2 diabetes mellitus were evaluated for their baseline clinical and laboratory profile. Both males and females above the age of 18 years were included in the study. The laboratory investigations include fasting serum C peptide, HbA1C, serum creatinine, blood urea nitrogen, urine albumin and creatinine. Creatinine clearance was calculated using modification of diet in renal disease formula from serum creatinine value. A total of 168 patients were included in the study, among them 90 were females (53.57%) and 78 males (46.43%). Mean age of the patients was 57.64 years. Pearson correlation test showed negative correlation of serum C peptide level with creatinine clearance, though statistically not significant. Negative correlation was also seen between serum C peptide, and urine albumin, urine albumin creatinine ratio, HbA1C and duration of diabetes. Mean urine albumin was higher in patients with subnormal C peptide level. Duration of disease was more in patients with lower serum C peptide level. The study has shown weak association of serum C peptide level with microalbuminuria and creatinine clearance. Risk of albuminuria is more in patients with low serum C peptide level.

Impact of Chronic Periodontitis on Levels of Glucoregulatory Biomarkers in Gingival Crevicular Fluid of Adults with and without Type 2 Diabetes

“…C-peptide is a polypeptide secreted from the secretory granules of β-cells during the conversion of pro-insulin to insulin [ 31 ]. C-peptide and insulin are released into the circulation in comparable amounts, but C-peptide is a more reliable indicator of β-cell activity, as it has a longer half-life and is not affected by insulin-specific antibodies [ 32 ]. To date, there are no published data on the relationship between periodontal disease and C-peptide levels in adults with T2DM.…”

Correlations between Glucagon Stimulated C-peptide Levels and Microvascular Complications in Type 2 Diabetes Patients

“…A low level of C-peptide is an indicator of the progression of diabetic angiopathies [ 5 ]. In addition, C-peptide decreases glomerular hyperfiltration and albuminuria in type 1 diabetes mellitus (DM) [ 6 ].…”

High levels of serum C-peptide are associated with a decreased risk for incident renal progression in patients with type 2 diabetes: a retrospective cohort study

“…Moreover, some studies have shown conflicting results. A prospective cross-sectional study in India only elucidated a weak correlation between serum C-peptide levels and microalbuminuria or creatinine clearance 29. A Turkish study concluded that increased serum C-peptide levels were not associated with microvascular complications in T2DM patients 30.…”

“…A prospective cross-sectional study in India only elucidated a weak correlation between serum C-peptide levels and microalbuminuria or creatinine clearance. 29 A Turkish study concluded that increased serum C-peptide levels were not associated with microvascular complications in T2DM patients. 30 The reasons for the heterogeneity of these results are the small sample sizes, limited statistical effects, or racial differences among the studies.…”