Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance

Fujinami, Aya; Ohta, Kiyoe; Obayashi, Hiroshi; Fukui, Michiaki; Hasegawa, Goji; Nakamura, Naoto; Kozai, Hana; Imai, Saeko; Ohta, Mitsuhiro

doi:10.1016/j.clinbiochem.2008.03.003

Cited by 137 publications

(124 citation statements)

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“…In addition to major depression, reduced serum and plasma BDNF levels have also recently been reported in several other disorders including; schizophrenia (26), bipolar disorder (27), eating disorders such as bulimia nervosa and anorexia nervosa (28), Huntington's disease (29), Alzheimer's disease (30), autism (31) and even lower respiratory infections (32). Interestingly, there are also several recent reports suggesting that BDNF levels are decreased in individuals with type-2 diabetes (33,34) and purporting a link between reduced circulating BDNF levels and metabolic syndrome (35,36). Although the seemingly non-specific association of reduced serum BDNF levels to a broad range of disorders detracts from its appeal as a specific diagnostic biomarker, it may inform us about a common pathophysiological mechanism that is shared by several different disease processes.…”

Section: What Is the Utility Of The Measure As A Biomarker?mentioning

confidence: 99%

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Sen

Duman

Sanacora

2008

Biological Psychiatry

1,082

715

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Section: What Is the Utility Of The Measure As A Biomarker?mentioning

confidence: 99%

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Sen

Duman

Sanacora

2008

Biological Psychiatry

1,082

715

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“…44 It has been suggested that this inhibition is due to an increase in skin and visceral blood flow to regulate temperature that limits blood flow to tissues, such as muscle and fat, which are sensitive to insulin and are active in glucose absorption. 44 An investigation of BDNF concentrations and glucose metabolism in type II diabetic patients found a strong relationship between BDNF and immunoreactive insulin in females, 43 suggesting a relationship between plasma glucose and BDNF concentrations. The mechanism is possibly a result of BDNF assisting insulin in the glucose management process and not BDNF responding to the process of glucogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…42,43 Our protocol altered the metabolic and energy management responses to exercise via environmental temperature manipulation. Contrary to the proposed hypotheses, a temperature related difference in exercise-dependent BDNF release was not discovered, but changes in metabolism across temperatures did occur, as evidenced by the difference in exercise VO 2 between temperature trials.…”

Section: Discussionmentioning

confidence: 99%

The effect of environmental temperature on exercise-dependent release of brain-derived neurotrophic factor

et al. 2017

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Brain-derived neurotrophic factor (BDNF) is a biomarker of cognitive function that is released into the blood stream following exercise, and cognitive function is impaired by environmental temperatures that are hot and cold. Purpose: To evaluate the exercise-dependent release of BDNF in different environmental temperatures. Methods: Recreationally trained males each completed three trials consisting of cycling for 1 h at 60% W max at three different temperatures: 33 C (hot), 7 C (cold), and 20 C (moderate room temperature). Blood was taken from the antecubital vein preexercise, immediately post-exercise, and 3 h post-exercise. Respiratory gases were collected periodically throughout exercise and recovery. Results: BDNF was elevated immediately following an exercise bout (1711 § 766 pg·ml ¡1 ) regardless of temperature from pre-exercise (1257 § 653 pg·ml ¡1 , p D 0.001) and returned to basal levels following 3 h of recovery (1289 § 650 pg·ml ¡1 , p D 0.786). There was no effect (p > 0.05) of temperature on BDNF following the exercise bout. Plasma glucose was elevated in hot (6.2 § 0.9 mmol) over cold (5.3 § 0.6 mmol, p D 0.035) and moderate room temperature (5.2 § 0.5, p D 0.008). VO 2 was elevated during exercise in hot (3.01 § 0.

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“…For example, in MCI, decreases in peripheral concentrations of BDNF are associated with age-related hippocampal dysfunction and memory impairment (Coelho et al 2013). In type-2 diabetes, changes in glucose metabolism and insulin resistance are associated with decreased BDNF concentrations (Krabbe et al 2007;Fujinami et al 2008). Critically, several studies have reported that exercise, specifically aerobic training, increases peripheral concentrations of BDNF in healthy older adults and in people with MCI.…”

Section: Role Of Exercise In Mitigating Sivcimentioning

confidence: 99%

The role of exercise in mitigating subcortical ischemic vascular cognitive impairment

Dao

Hsiung

Liu-Ambrose

2017

Journal of Neurochemistry

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Subcortical ischemic vascular cognitive impairment (SIVCI) is the most preventable form of cognitive dysfunction. There is converging evidence from animal and human studies that indicate vascular injury as the primary cause of SIVCI. Currently, there are no curative pharmaceutical treatments for vascular dementia; however, exercise may be a promising strategy to combat SIVCI. This review will focus on the role of exercise as a strategy to prevent or slow the progression of SIVCI, with particular emphasis on the mechanisms by which exercise may improve cerebrovascular function. We propose that exercise may be an effective strategy to combat SIVCI by improving cognitive function, increasing the bioavailability of neurotrophins, stimulating endothelial function, and controlling vascular risk factors. Keywords: endothelial function, exercise, subcortical ischemic vascular cognitive impairment, white matter hyperintensities. J. Neurochem. (2018) 144, 582--594.This article is part of the Special Issue "Vascular Dementia".The World Health Organization estimates that 47.5 million people worldwide are living with dementia with an expected increase of 7.7 million new cases each year (World Health Organization 2012). Dementia is a common cause of disability and dependency among older adults; thus, the high prevalence and incidence of dementia is a great burden to health, social, and financial systems (World Health Organization 2012). Vascular cognitive impairment (VCI) is the second leading cause of cognitive impairment and dementia (van Norden et al. 2012). Vascular cognitive impairment is an umbrella term that encompasses the full spectrum of cognitive and functional impairments associated with cerebrovascular disease, from frank dementia to mild cognitive deficits (Gorelick et al. 2011). Subcortical ischemic vascular cognitive impairment (SIVCI) is the most common form of VCI and is caused by cerebral small vessel disease (SVD) (Moorhouse and Rockwood 2008). Cerebral SVD is caused by chronic and diffuse ischemia and is most often associated with damage to cerebral white matter. Specifically, it manifests as white matter hyperintensities (WMH), lacunes, enlarged perivascular spaces, and microbleeds (Wardlaw et al. 2013b).Overall, there is converging evidence from animal and human studies that indicate vascular injury as the primary cause of SIVCI (Iadecola 2013). Vascular risk factors such as Received May 29, 2017; revised manuscript received August 9, 2017; accepted August 11, 2017.Address correspondence and reprint requests to Teresa Liu-Ambrose, University of British Columbia, Djavad Mowafaghian Centre for Brain Health, 2215 Wesbrook Mall, Vancouver, BC V6T 1Z3. USA. E-mail: teresa.ambrose@ubc.caAbbreviations used: ADAS-Cog, Alzheimer's Disease Assessment Scale-cognitive subscale; BDNF, brain-derived neurotrophic factor; CBF, cerebral blood flow; eNOS, endothelial nitric oxide synthase; fMRI, functional magnetic resonance imaging MRI; IGF-1, insulin-like growth factor 1; MCI, mild cognitive impairment; MRI, m...

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Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance

Cited by 137 publications

References 39 publications

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

The effect of environmental temperature on exercise-dependent release of brain-derived neurotrophic factor

The role of exercise in mitigating subcortical ischemic vascular cognitive impairment

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