Serum brain-derived neurotrophic factor and neurocognitive function in children with type 1 diabetes

Chen, Hui Ju; Lee, Yann Jinn; Huang, Chunmao; Lin, Yuh Feng; Li, Sung Tse

doi:10.1016/j.jfma.2020.04.011

Cited by 9 publications

(3 citation statements)

References 38 publications

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“…BDNF levels are essential in the survival, growth and differentiation of new neurons during early brain development and are involved in the plasticity changes related to learning, memory, and higher cognitive function ( 17 ). Lower BDNF levels have also been linked with poorer neurocognitive function in children with type I diabetes ( 43 ). Our results indicate a possible role for BDNF in the neurocognitive complications seen in pediatric OSA.…”

Section: Discussionmentioning

confidence: 99%

The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity

et al. 2022

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BackgroundChildhood obesity has increased worldwide, becoming a significant public health concern. Brain-derived neurotrophic factor (BDNF) plays an important role in the central regulation of food intake and body weight, but little is known regarding its role in childhood obesity. Next to obesity, BDNF has been linked to obstructive sleep apnea (OSA) and endothelial dysfunction, two obesity-related comorbidities. The aim of this study is to investigate how BDNF, OSA and endothelial dysfunction interact in children with obesity and to determine the effect of weight loss on serum BDNF levels.MethodsChildren and adolescents with obesity aged 8–18 years who were enrolled in a multidisciplinary obesity treatment (MOT) in a tertiary hospital, were prospectively included. Several examinations were conducted during this MOT; at baseline, after 6 months and after 12 months, including the assessment of endothelial function, body composition measurements and a polysomnography. BDNF levels were measured on a serum sample by means of ELISA.ResultsA total of 103 patients with obesity was included, of which 20 had OSA (19.4%). BDNF levels were comparable in children with obesity and OSA and children with obesity but without OSA (26.75 vs. 27.87 ng/ml, p = 0.6). No correlations were found between BDNF and sleep-related variables or between BDNF and endothelial function parameters nor between BDNF and adiposity measures. To investigate if the interaction between OSA and endothelial dysfunction had an influence on BDNF levels, a general linear model was used. This model revealed that a diagnosis of OSA, as well as the interaction between OSA and maximal endothelial dilatation, contributed significantly (p = 0.03, p = 0.04, respectively) to BDNF levels. After 1 year of weight loss therapy, BDNF levels did not change (26.18 vs. 25.46 ng/ml, p = 0.7) in our population.ConclusionBDNF concentrations were comparable in children with obesity, both with and without OSA, indicating that BDNF levels are not affected by OSA. However, we did find an interaction effect of OSA and endothelial function on BDNF levels.

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Section: Discussionmentioning

confidence: 99%

The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity

et al. 2022

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“…Furthermore, low levels of BDNF have been reported in newborns who later developed ASD, suggesting its potential as a biomarker for neurodevelopmental disorders ( 121 ). In children with T1DM, particularly those with positive anti-GAD65 antibodies, lower serum BDNF levels and suboptimal neurocognitive performance have been observed ( 122 ). BDNF has also demonstrated neuroprotective effects against various adverse insults that threaten brain homeostasis, including cerebral ischemia, hypoglycemia, and GABAergic stimulations.…”

Section: Maternal Diabetes and The Fetal Brainmentioning

confidence: 99%

The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence

et al. 2023

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Maternal health during gestational period is undoubtedly critical in shaping optimal fetal development and future health of the offspring. Gestational diabetes mellitus is a metabolic disorder occurring in pregnancy with an alarming increasing incidence worldwide during recent years. Over the years, there is a growing body of evidence that uncontrolled maternal hyperglycaemia during pregnancy can potentially have detrimental effect on the neurodevelopment of the offspring. Both human and animal data have linked maternal diabetes with motor and cognitive impairment, as well as autism spectrum disorders, attention deficit hyperactivity disorder, learning abilities and psychiatric disorders. This review presents the available data from current literature investigating the relationship between maternal diabetes and offspring neurodevelopmental impairment. Moreover, possible mechanisms accounting for the detrimental effects of maternal diabetes on fetal brain like fetal neuroinflammation, iron deficiency, epigenetic alterations, disordered lipid metabolism and structural brain abnormalities are also highlighted. On the basis of the evidence demonstrated in the literature, it is mandatory that hyperglycaemia during pregnancy will be optimally controlled and the impact of maternal diabetes on offspring neurodevelopment will be more thoroughly investigated.

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“…Recently, epidemiologic study in Taiwan had shown that from 2004 to 2015, T1D accounted for 0.51-0.59% of the entire diabetic population, the standardized incidence of T1D slightly decreased by 11%, and the standardized prevalence of T1D increased from 0.04% to 0.05% [ 28 ]. The verbal comprehension, perceptual reasoning, and working memory scores in the T1D group were significantly lower than in the controls [ 29 ]. However, the association between the age at onset, ophthalmic parameters, diabetic retinopathy, and cognitive dysfunction in T1D had not been explored.…”

Section: Introductionmentioning

confidence: 99%

Retinal Thickness Associates with Cognition Dysfunction in Young Adult with Type 1 Diabetes in Taiwan

Hsu

Kang

et al. 2022

Journal of Diabetes Research

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Background. Several factors could affect the cognitive dysfunction in patients with type 1 diabetes (T1D). Objectives. To report the characteristic of cognitive dysfunction in T1D and find its association with the retinal thickness. Subjects. We recruited one hundred and seven patients with T1D in our study. Methods. Detailed clinical and demographic factors and Cambridge Automated Neuropsychological Test Battery (CANTAB) were performed in all participants. The age at onset > 5 years old and ≤5 years old groups was defined as old- and young-onset groups. The levels of the average values of 5-year glycated hemoglobin (HbA1c_5) before study were collected. Ophthalmic study and central retinal thickness (CRT) were performed. Results. The median age of T1D was 24.9 years old and 57 participants were women. The median age at onset was 7.4 years old, and mean disease duration was 17.2 years. After adjusting off multiple covariates by the regression analyses, the young-onset group had significantly a longer latency in sustained attention than old-onset group ( P = 0.02 ). The HbA1c_5 showed a significantly negative association with the sustained attention ( P = 0.03 ). The average values of CRT showed significantly negative correlations with the reaction time in sustained attention and visual searching ( P = 0.04 and P < 0.01 , respectively). Conclusions. Our results suggest that age at onset and glycemic control had significant impacts on different cognitive domains in T1D. The CRT had a significant correlation with sustained attention, which could be a surrogate markers of brain structural changes in T1D.

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Serum brain-derived neurotrophic factor and neurocognitive function in children with type 1 diabetes

Cited by 9 publications

References 38 publications

The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity

The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity

The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence

Retinal Thickness Associates with Cognition Dysfunction in Young Adult with Type 1 Diabetes in Taiwan

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