Serum Bisphenol A concentrations in men with idiopathic infertility

Mantzouki, Christina; Bliatka, Despoina; Iliadou, Paschalia K; Margeli, Alexandra; Papassotiriou, Ioannis; Mastorakos, George; Kousta, Eleni; Goulis, Dimitrios G.

doi:10.1016/j.fct.2019.02.016

Cited by 21 publications

(9 citation statements)

References 41 publications

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“…BPA has been shown to be associated with impaired reproductive function in men and women. For example, in a study in Greece, very high concentrations of plasma BPA were associated with azoospermia in men [156]. Further, in a cross-sectional study with young men, high levels of urinary BPA were positively associated with serum luteinizing hormone (LH) levels and negatively associated with sperm concentration [5].…”

Section: Humansmentioning

confidence: 99%

Endocrine Disruptors in Water and Their Effects on the Reproductive System

Gonsioroski

Mourikes

Flaws

2020

IJMS

197

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Anthropogenic contaminants in water can impose risks to reproductive health. Most of these compounds are known to be endocrine disrupting chemicals (EDCs). EDCs can impact the endocrine system and subsequently impair the development and fertility of non-human animals and humans. The source of chemical contamination in water is diverse, originating from byproducts formed during water disinfection processes, release from industry and livestock activity, or therapeutic drugs released into sewage. This review discusses the occurrence of EDCs in water such as disinfection byproducts, fluorinated compounds, bisphenol A, phthalates, pesticides, and estrogens, and it outlines their adverse reproductive effects in non-human animals and humans.

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Section: Humansmentioning

confidence: 99%

Endocrine Disruptors in Water and Their Effects on the Reproductive System

Gonsioroski

Mourikes

Flaws

2020

IJMS

197

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“…In males, EDCs exposure was associated with declined semen quality, increased sperm DNA damage, alterations in testis morphology and endocrine function [ 20 , 53 , 54 , 55 ]. Mantzouki and colleagues demonstrated that very high concentrations of plasma BPA (>3 ng/mL) were associated with azoospermia in humans [ 56 ]. A cross-sectional study performed on 215 healthy young university students (18–23 years old) revealed a significant positive association between urinary BPA concentrations (2.8 (0.16–11.5) ng/mL) and serum LH levels as well as a significant and inverse association with sperm concentration and the total sperm count, thus concluding that BPA exposure may be associated with a reduction in Leydig cell capacity and decreased sperm counts in young men [ 57 ].…”

Section: Edcs and Reproductive Healthmentioning

confidence: 99%

Fetal–Maternal Exposure to Endocrine Disruptors: Correlation with Diet Intake and Pregnancy Outcomes

et al. 2020

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Endocrine-disrupting chemicals (EDCs) are exogenous substances able to mimic or to interfere with the endocrine system, thus altering key biological processes such as organ development, reproduction, immunity, metabolism and behavior. High concentrations of EDCs are found in several everyday products including plastic bottles and food containers and they could be easily absorbed by dietary intake. In recent years, considerable interest has been raised regarding the biological effects of EDCs, particularly Bisphenol A (BPA) and phthalates, on human pregnancy and fetal development. Several evidence obtained on in vitro and animal models as well as by epidemiologic and population studies strongly indicated that endocrine disruptors could negatively impact fetal and placental health by interfering with the embryonic developing epigenome, thus establishing disease paths into adulthood. Moreover, EDCs could cause and/or contribute to the onset of severe gestational conditions as Preeclampsia (PE), Fetal Growth Restriction (FGR) and gestational diabetes in pregnancy, as well as obesity, diabetes and cardiovascular complications in reproductive age. Therefore, despite contrasting data being present in the literature, endocrine disruptors must be considered as a therapeutic target. Future actions aimed at reducing or eliminating EDC exposure during the perinatal period are mandatory to guarantee pregnancy success and preserve fetal and adult health.

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“…The findings are supported by a Greek case-control study reporting stronger association between urinary BPA levels and sperm motility in infertile compared to fertile men [50]. Mantzouki et al (2019) reached a different conclusion when comparing serum BPA in fertile and infertile men from Greece, since no difference in semen characteristics was reported [51]. However, one must keep in mind that urinary BPA levels do, to a greater extent, reflect the excretion rate of BPA, while measurements of plasma BPA rather reflect its bioavailability.…”

Section: Findings In Relation To Other Studiesmentioning

confidence: 82%

Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men

Benson

Gaml‐Sørensen

Ernst

et al. 2021

IJERPH

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Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross–sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18–20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile–divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre–pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.

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Serum Bisphenol A concentrations in men with idiopathic infertility

Cited by 21 publications

References 41 publications

Endocrine Disruptors in Water and Their Effects on the Reproductive System

Endocrine Disruptors in Water and Their Effects on the Reproductive System

Fetal–Maternal Exposure to Endocrine Disruptors: Correlation with Diet Intake and Pregnancy Outcomes

Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men

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