Serum bisphenol A analogues in women diagnosed with the polycystic ovary syndrome – is there an association?

Jurewicz, Joanna; Majewska, Joanna; Berg, Andrzej; Owczarek, Katarzyna; Zajdel, Radosław; Kaleta, Dorota; Wasik, Andrzej; Rachoń, Dominik

doi:10.1016/j.envpol.2020.115962

Cited by 27 publications

(25 citation statements)

References 53 publications

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“…In particular, Akin et al’s study, which evaluated 173 female adolescents, reported statistically significantly higher mean BPA levels in PCOS women compared to healthy women (1.1 ng/mL vs. 0.8 ng/mL), as well as a statistically significant correlation between BPA and androgen levels [ 22 ]. More recent publications confirm the aforementioned association of high BPA levels and PCOS [ 29 , 31 , 36 , 48 , 52 ]. In particular, a research group from Poland reported significantly higher BPA levels in women with PCOS compared to the control group ( p = 0.035) and a positive correlation of BPA with FAI and serum total testosterone (TT) [ 31 ].…”

Section: Resultssupporting

confidence: 53%

Bisphenol-A and Female Fertility: An Update of Existing Epidemiological Studies

Stavridis

Triantafyllidou

Pisimisi

et al. 2022

JCM

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Humans interfere with a variety of endocrine disruptors on a daily basis, which may result in adverse health effects. Among them, Bisphenol-A (BPA) is the most debated endocrine disruptor, despite being widely studied, regarding its effects on fertility. The aim of this review was to investigate the interrelation of BPA and female fertility. PubMed (Medline) was searched from 2013 until 2022 to identify epidemiological studies that report the association of BPA with fertility parameters, in vitro fertilization (IVF) outcomes, polycystic ovarian syndrome (PCOS) and endometriosis. Regarding general fertility, most studies report an inverse association between BPA and ovarian reserve markers, namely antral follicle count (AFC) and anti-Müllerian hormone (AMH). The BPA and estradiol (E2) levels did not correlate significantly in the majority of studies. No definite conclusions can be reached regarding BPA and IVF endpoints or endometriosis. Lastly, most studies report higher prevalence of PCOS in women with higher BPA concentrations, although no casualty has been proven. Although most studies fail to reach definite conclusion regarding the impact of BPA on fertility, there is accumulating evidence suggesting a negative role of BPA in female reproductive health.

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Section: Resultssupporting

confidence: 53%

Bisphenol-A and Female Fertility: An Update of Existing Epidemiological Studies

Stavridis

Triantafyllidou

Pisimisi

et al. 2022

JCM

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“…Furthermore, BPA exposure causes attenuation of aromatase expression in the follicular fluid causing dysregulation in estrogen production (Wang et al 2017). This paired with the potential of BPA to increase androgen levels due to its inhibitory effect on the action of testosterone-hydroxylase (Takeuchi et al 2006) has the ability to cause hyperandrogenism (Jurewicz et al 2021).…”

Section: Effect Of Bpa On Pcosmentioning

confidence: 99%

Review on bisphenol A and the risk of polycystic ovarian syndrome: an insight from endocrine and gene expression

Mukhopadhyay

Prabhu

Kabekkodu

et al. 2022

Environ Sci Pollut Res

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Bisphenol A (BPA) is one of the most widely studied endocrine disrupting chemicals because of its structural similarity to 17-β estradiol; its ability to bind as an agonist/antagonist to estrogen receptors elicits adverse effects on the functioning of the metabolic and endocrinal system. Therefore, BPA has been thoroughly scrutinized concerning its disruption of pathways like lipid metabolism, steroidogenesis, insulin signaling, and inflammation. This has resulted in reports of its correlation with various aspects of cardiovascular diseases, obesity, diabetes, male and female reproductive disorders, and dysfunctions. Among these, the occurrence of the polycystic ovarian syndrome (PCOS) in premenopausal women is of great concern. PCOS is a highly prevalent disorder affecting women in their reproductive age and is clinically characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology, along with metabolism-related dysfunctions like hyperinsulinemia, obesity, and insulin resistance. In this review, we analyzed certain researched effects of BPA, while focusing on its ability to alter the expression of various significant genes like GnRH, AdipoQ, ESR1, StAR, CYP11A1, CYP19A1, and many more involved in the pathways and endocrine regulation, whose disruption is commonly associated with the clinical manifestations of PCOS.

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“…[33][34][35][36] Experimental results indicated that exposure to BPA is linked to diagnosis of PCOS and serum concentration of BPS (bisphenol S, analogue of BPA) in serum is high in women with PCOS. 37 It has been observed by substantial evidence from experiments in mice and rats that they are susceptible to mammary gland cancer following BPA exposures below the oral reference dose (RfD) 38,39 It has been revealed that elevation of urinary BPA levels is associated with prostate cancer in humans. 40 Review has been done on environmental chemicals where Zebra fish (Danio rerio) is used as a model animal for the toxicological study to show the effects of these chemicals as endocrine disruptors.…”

Section: Commentary/notementioning

confidence: 99%

“…Bisphenol A (BPA) & Dioxin Carcinogenic [9] Polychlorinated biphenyls (PCBs) & parabens Enhances breast cancer risk [10], [16], [17] BPA Enhances breast cancer risk [16,38,39] Carcinogenic for reproductive organs of women [11] Modulate estrogen signaling by interacting with estrogen receptors (ERs) [12] Causes epigenetic modifications in different cancers [13] Induce prostate and bladder cancer [14,40] Associates with ovarian and endometrial cancer risk [17] Associated with fertility related complications and induction/pathogenesis of poly-cystic ovarian syndrome (PCOS) [18,19,27,28,[33][34][35][36]37] Related to female endocrine disruption and reproductive complications [20][21][22][23][24] Interferes steroidogenesis in ovarian granulosa cells [25] Female reproductive and metabolic disorders such as PCOS, hyper-androgenism, insulin resistance, and obesity [18,19,30,31] PCBs, Phthalates, BPA, Polyfluoroalkyl Substances (PFAS), Agricultural Pesticides (Organochlorine, Organophosphate, alachlor and triazine)…”

Section: Edc Compound Action/effect Referencesmentioning

confidence: 99%

Impact of endocrine disrupting chemicals (EDCs) on the predisposition of cancer and polycystic ovary syndrome (PCOS): A Note

Bhattacharjee¹,

Sarkar

Giri

2022

J. Drug Delivery Ther.

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Endocrine Disrupting Chemicals (EDCs) or Endocrine Disruptors are unique assemblage or cluster of emerging pollutants as they affect the synthesis, release and transport of hormones. EDCs have been associated with a diverse array of health issues and diseases. EDCs can alter the endocrine system and are involved in carcinogenesis and inducing poly-cystic ovary syndrome (PCOS). The objective of this article is to furnish an outline of research on environmental aspects of EDCs and their effects on human health specially on cancer and PCOS based on evidence from animal and human studies. EDCs include natural compounds such as phytoestrogens and various synthetic chemicals which are utilized by the chemical, agriculture, cosmetic and food industries. Several EDCs may work as carcinogens and causes initiation and advancement of cancer. Uterine and ovarian cancers of female have been associated with exposure to EDC. Bisphenol-A (BPA), an EDC which is found in plastic bottles, household materials, canned food, waste water, beverage containers and thermal paper, can increase risk of breast cancer. Even low levels of BPA exposure may poses threat of prostate cancer in men. Testicular cancer and thyroid cancer could be influenced by EDCs. Comprehensive studies have been conducted by many researchers in the light of toxicity pattern of EDC that render interpretation of impact of EDCs on development of cancer and PCOS inducing capacity in female reproductive system. Keywords: Endocrine disrupting chemicals; EDC; Cancer; Endocrine Disruptor, Poly-Cystic Ovary Syndrome; PCOS

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Serum bisphenol A analogues in women diagnosed with the polycystic ovary syndrome – is there an association?

Cited by 27 publications

References 53 publications

Bisphenol-A and Female Fertility: An Update of Existing Epidemiological Studies

Bisphenol-A and Female Fertility: An Update of Existing Epidemiological Studies

Review on bisphenol A and the risk of polycystic ovarian syndrome: an insight from endocrine and gene expression

Impact of endocrine disrupting chemicals (EDCs) on the predisposition of cancer and polycystic ovary syndrome (PCOS): A Note

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