Serum biomarkers for arterial calcification in humans: A systematic review

Golüke, Nienke M.S.; Schoffelmeer, Marit A; Jonghe, Annemarieke de; Emmelot-Vonk, Mariëlle H.; Jong, Pim A. de; Koek, Huiberdina L.

doi:10.1016/j.bonr.2022.101599

Cited by 12 publications

(6 citation statements)

References 143 publications

(395 reference statements)

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“…Several clinical studies have investigated the possible association between OPG and arterial calci cation. Out of these studies, 19 reported a positive association, 2 reported negative association and 17 reported no association at all [15].…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Osteoprotegerin and RANKL Levels and Several Cardiovascular Risk Scoring Systems in Acromegaly

Kocabaş

Yürekli

Şimşir

et al. 2023

Preprint

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Purpose The OPG/RANKL (Osteoprotegerin/Receptor Activator of Nuclear Factor Kappa-B) system, which plays a crucial role in bone metabolism, is also associated with vascular calcification. Acromegaly is characterized by excessive secretion of growth hormone and insulin -like growth factor and studies have demonstrated an elevated risk of cardiovascular disease in individuals with acromegaly. In this study our objective was to investigate the relationship between OPG/RANKL and various cardiovascular risk scoring systems. Methods We recruited 44 consecutive acromegaly patients and 41 age- and gender-matched healthy controls for this study. Results While RANKL levels were significantly higher in the acromegaly group compared to the controls, OPG levels were not found to be significantly different between the two groups, Furthermore, within the acromegaly group, RANKL levels were significantly higher in patients with active acromegaly compared to those with controlled acromegaly. Osteoprotegerin levels showed a positive correlation with Framingham Risk Score (FRS) in the acromegaly group. Linear regression analysis revealed association of OPG with FRS (adjusted R2 value of 21.7%) Conclusion In conclusion, OPG and RANKL may serve as potential markers for assessing cardiovascular calcification and predicting the cardiovascular risk status in acromegalic patients.

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Section: Discussionmentioning

confidence: 99%

“…Mediators of bone metabolism seem to play an active role in this transformation process. This medial calci cation leads to arterial stiffening which in turn results in cardiovascular disease [15]. OPG and RANKL, which are important regulators of bone metabolism are also considered to be involved in ectopic mineralization.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Osteoprotegerin and RANKL Levels and Several Cardiovascular Risk Scoring Systems in Acromegaly

Kocabaş

Yürekli

Şimşir

et al. 2023

Preprint

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“…Most studies are of a poor quality, were mainly cross-sectional, and were influenced by confounding factors. The most recent meta-analysis included several biomarkers: calcium, phosphate, parathyroid hormone, vitamin D, pyrophosphate, OPG, RANKL, FGF-23, Klotho, osteopontin, osteocalcin, MGP and its inactive forms, and vitamin K. Of all the markers included, phosphate, osteopontin, and FGF-23 were found to be suitable biomarkers for MAC [ 124 ]. However, further studies are needed to test their predictive value for the development of MAC.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Inflammatory, Metabolic, and Coagulation Effects on Medial Arterial Calcification in Patients with Peripheral Arterial Disease

Nikolajević

Šabovič

2023

IJMS

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Calcium deposits in the vessel wall in the form of hydroxyapatite can accumulate in the intimal layer, as in atherosclerotic plaque, but also in the medial layer, as in medial arterial calcification (MAC) or medial Möenckeberg sclerosis. Once considered a passive, degenerative process, MAC has recently been shown to be an active process with a complex but tightly regulated pathophysiology. Atherosclerosis and MAC represent distinct clinical entities that correlate in different ways with conventional cardiovascular risk factors. As both entities coexist in the vast majority of patients, it is difficult to estimate the relative contribution of specific risk factors to their development. MAC is strongly associated with age, diabetes mellitus, and chronic kidney disease. Given the complexity of MAC pathophysiology, it is expected that a variety of different factors and signaling pathways may be involved in the development and progression of the disease. In this article, we focus on metabolic factors, primarily hyperphosphatemia and hyperglycemia, and a wide range of possible mechanisms by which they might contribute to the development and progression of MAC. In addition, we provide insight into possible mechanisms by which inflammatory and coagulation factors are involved in vascular calcification processes. A better understanding of the complexity of MAC and the mechanisms involved in its development is essential for the development of potential preventive and therapeutic strategies.

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“…Цікаво, що блокування остеохондрогенного диференціювання VSMC впливало на кальцифікацію, але не на системний ліпідний обмін, експресію ліганда активатора рецептора ядерного фактора каппа-В (RANKL), залучення моноцитів/макрофагів або розмір атеросклеротичного ураження. Ці дані вперше виявили генетичний поділ між кальцифікуючим склеротичним процесом і ліпідним, атерогенним процесом, надаючи змогу припустити, що різні механізми регулюють формування та прогресування кальцифікації та атероми відповідно до відмінностей в етіології між ІАК та атерогенезом [51].…”

Section: вплив окиснювального стресу та мітохондріальної дисфункції н...unclassified

Arterial stiffness, vascular calcification and osteoporosis — common mechanisms of interaction (literature review)

Nishkumay

Mostbauer

Alekseenko

et al. 2022

PJS

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Introduction. The problem of cardiovascular morbidity and mortality remains an urgent issue of modern medicine, and arterial stiffness is its independent predictor. Lively discussions about the correct approach to the prevention and treatment of comorbid conditions – increased vascular stiffness as an influential factor of the cardiovascular events and decreased bone mineral density (osteoporosis), primarily arise against the background of the need and safety of calcium and vitamin D supplements. The purpose was to search for literature data as for possible common pathogenetic links in the progression of arterial stiffness and the development of osteoporosis in order to assess the safety of the use of drugs to prevent osteoporotic fractures. Results. Analysis of literature sourses had showed that possible osteogenic factors affecting arterial stiffness may be: secondary hyperparathyroidism, disbalance of the RANK/RANKL/OPG system, inhibition of vitamin K-dependent matrix proteins (Gla-protein), osteopontin, etc. Conclusions. Today, there are many hypotheses confirming the possible influence of osteogenic factors on vascular stiffness and arterial calcification. Therefore, the search for sensitive markers and the development of screening protocols for the patients with risk factors for both osteoporosis and vascular changes are extremely relevant. A special issue is the possibility of using monotherapy for these comorbid pathologies, which can safely and efficiently influence the prevention of complications – both low-energy osteoporotic fractures and cardiovascular catastrophes. This will be the focus of our further research.

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Serum biomarkers for arterial calcification in humans: A systematic review

Cited by 12 publications

References 143 publications

Assessment of Osteoprotegerin and RANKL Levels and Several Cardiovascular Risk Scoring Systems in Acromegaly

Assessment of Osteoprotegerin and RANKL Levels and Several Cardiovascular Risk Scoring Systems in Acromegaly

Inflammatory, Metabolic, and Coagulation Effects on Medial Arterial Calcification in Patients with Peripheral Arterial Disease

Arterial stiffness, vascular calcification and osteoporosis — common mechanisms of interaction (literature review)

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