2023
DOI: 10.3390/ijms24043132
|View full text |Cite
|
Sign up to set email alerts
|

Inflammatory, Metabolic, and Coagulation Effects on Medial Arterial Calcification in Patients with Peripheral Arterial Disease

Abstract: Calcium deposits in the vessel wall in the form of hydroxyapatite can accumulate in the intimal layer, as in atherosclerotic plaque, but also in the medial layer, as in medial arterial calcification (MAC) or medial Möenckeberg sclerosis. Once considered a passive, degenerative process, MAC has recently been shown to be an active process with a complex but tightly regulated pathophysiology. Atherosclerosis and MAC represent distinct clinical entities that correlate in different ways with conventional cardiovasc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
7
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 6 publications
(7 citation statements)
references
References 128 publications
0
7
0
Order By: Relevance
“…Inflammation and specific genotypes also present a critical regulatory in the development of medial calcification. Inflammation indirectly influences the pathogenesis of medial calcification by impacting the signaling pathways involved in its pathogenesis ( 15 , 21 ). Tumor necrosis factor-α (TNF-α) is the most important cytokine, involved in both bone and vascular physiology.…”
Section: Histological Features and Llacmentioning
confidence: 99%
See 3 more Smart Citations
“…Inflammation and specific genotypes also present a critical regulatory in the development of medial calcification. Inflammation indirectly influences the pathogenesis of medial calcification by impacting the signaling pathways involved in its pathogenesis ( 15 , 21 ). Tumor necrosis factor-α (TNF-α) is the most important cytokine, involved in both bone and vascular physiology.…”
Section: Histological Features and Llacmentioning
confidence: 99%
“…This will probably influence localized blood flow, and it has also been suggested that it may exacerbate the consequences of aortic stiffness and affect brain and heart health ( 67 ). Pulse wave velocity is a diagnostic tool for peripheral arterial disease and a measurement of arterial stiffness, but it does not offer direct insights into the anatomical characteristics or biological processes of atherosclerotic plaques ( 21 , 68 ). Further research is needed to define these mechanisms.…”
Section: Clinical Relevance Of Llacmentioning
confidence: 99%
See 2 more Smart Citations
“…A clear factor of reduced wall distensibility of the arterial wall during aging is the calcium deposition within the arterial wall [ 16 ]. Although it is not clear why aging is characterized by an increased calcification of the vessel wall, it has been postulated that inflammation and oxidative stress may play a role, as both occur during aging.…”
Section: Arterial Wall Remodeling During Agingmentioning
confidence: 99%