Serum B12, homocysteine levels, and their effect on peripheral neuropathy in Parkinson's disease: Indian cohort

Mathukumalli, Neeharika L; Kandadai, Mridula R; Shaik, Jabeen A; Kanikannan, Meena A; Borgohain, Rupam

doi:10.4103/aian.aian_478_18

Cited by 9 publications

(2 citation statements)

References 36 publications

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“…The associations between cumulative levodopa dose and vitamin B 12 level in the current study also indicated that vitamin B 12 levels were decreased with increasing exposure to levodopa in the PD group. This may be explained by the fact that accumulated levodopa can lead to higher homocysteine, which may pose a potential risk of inducing neuropathy (36,37). In this study, no correlations were noticed between levodopa equivalent daily dose with other parameters.…”

Section: Discussioncontrasting

confidence: 69%

Changes of Peripheral Nerve Function and Vitamin B12 Level in People With Parkinson's Disease

Qiu

Cao

et al. 2020

Front. Neurol.

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Background and Purpose: Peripheral nerve function plays an important role in balance control. Impairment of peripheral sensory information appears in people with Parkinson's disease (PD). Furthermore, there is a link between peripheral nerve disorders and vitamin B12 level. Here, we studied whether there were deficits of peripheral nerve function and vitamin B12 level, which may lead to decreased postural stability in PD.Methods: Fifty PD and 50 age-matched healthy subjects were enrolled in the study. This study evaluated folic acid and vitamin B12 levels in serum. Postural balance was studied according to the clinical Tinetti scale. Some comprehensive physiological assessments of peripheral nerve functions, including peripheral sensation, the perception of temperature, pain, and touch sensations, were also undertaken in this study.Results: Compared with the control group, vitamin B12 and folic acid were decreased in PD (P < 0.05). Furthermore, the PD group exhibited declines in peripheral nerve functions, including touch, temperature, pain, and nerve conduction velocity (P < 0.05). Statistical tests identified a significant association between decreased peripheral nerve function and poor balance according to the Tinetti scale (P < 0.05). Low vitamin B12 levels were also associated with deficits of peripheral nerve function, cumulative levodopa dose, and poor balance in PD (P < 0.05).Conclusions: Data suggested that peripheral nerve function was impaired in people with PD. Deficits of sensory input and low vitamin B12 level may contribute to balance deficits in PD.

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Section: Discussioncontrasting

confidence: 69%

Changes of Peripheral Nerve Function and Vitamin B12 Level in People With Parkinson's Disease

Qiu

Cao

et al. 2020

Front. Neurol.

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“…L-DOPA may not only cause vitamin-B12 deficiency (L-DOPA induced vitamin-B12 deficiency), but also folate deficiency (10). The notion that L-DOPA causes vitamin-B12 or folate deficiency, and thus secondary PDRNP, has been challenged by findings from third world countries showing that low vitamin-B12 and folate levels do not play a significant role in the development of PDRNP (11). It has been increasingly recognized that levidopa/carbidopa intestinal gel (LCIG) can be complicated by NP, particularly SFN (12,13).…”

Section: ' Resultsmentioning

confidence: 99%

Parkinson-related neuropathy

Finsterer¹,

Scorza²,

Scorza³

et al. 2021

Clinics

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Parkinson's disease and vitamins: a focus on vitamin B12

Rekik,

Santoro,

Poplawska-Domaszewicz

et al. 2024

J Neural Transm

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Parkinson’s disease (PD) has been linked to a vast array of vitamins among which vitamin B12 (Vit B12) is the most relevant and often investigated specially in the context of intrajejunal levodopa infusion therapy. Vit B12 deficiency, itself, has been reported to cause acute parkinsonism. Nevertheless, concrete mechanisms through which B12 deficiency interacts with PD in terms of pathophysiology, clinical manifestation and progression remains unclear. Recent studies have suggested that Vit B12 deficiency along with the induced hyperhomocysteinemia are correlated with specific PD phenotypes characterized with early postural instability and falls and more rapid motor progression, cognitive impairment, visual hallucinations and autonomic dysfunction. Specific clinical features such as polyneuropathy have also been linked to Vit B12 deficiency specifically in context of intrajejunal levodopa therapy. In this review, we explore the link between Vit B12 and PD in terms of physiopathology regarding dysfunctional neural pathways, neuropathological processes as well as reviewing the major clinical traits of Vit B12 deficiency in PD and Levodopa-mediated neuropathy. Finally, we provide an overview of the therapeutic effect of Vit B12 supplementation in PD and posit a practical guideline for Vit B12 testing and supplementation.

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Serum B12, homocysteine levels, and their effect on peripheral neuropathy in Parkinson's disease: Indian cohort

Cited by 9 publications

References 36 publications

Changes of Peripheral Nerve Function and Vitamin B12 Level in People With Parkinson's Disease

Changes of Peripheral Nerve Function and Vitamin B12 Level in People With Parkinson's Disease

Parkinson-related neuropathy

Parkinson's disease and vitamins: a focus on vitamin B12

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