Parkinson-related neuropathy

Finsterer, Josef; Scorza, Fúlvio A.; Scorza, Carla A.; Fiorini, Ana Cláudia

doi:10.6061/clinics/2021/e2675

Cited by 2 publications

(1 citation statement)

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“…[ 4 ] While others suggest that the presence of genetic mutations is the cause of PD-related neuropathy. [ 9 ] To the best of our knowledge, this is the first study to access the corelation of nutritional status assessed by MNA scale with peripheral neuropathy and its impact on QOL of PD patients. Our findings favor old age and increasing duration of disease as the most significant risk factors for the occurrence of neuropathy in PD.…”

Section: Discussionmentioning

confidence: 99%

Neuropathy in Parkinson's disease: Risk determinants and impact on quality of life

Ravi

Paul

Aggarwal

et al. 2022

Ann Indian Acad Neurol

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Neuropathy has been described in significantly higher proportion of PD patients than in control subjects. This study ascertains the prevelance of neuropathy and its determinants in PD patients, in particular relation with nutritional status, along with impact of neuropathy on Quality of life. Methods: This was a hospital based observational cross-sectional study of PD patients attending the Neurology OPD of a tertiary care hospital. The prevalence and type of neuropathy was determined using the validated MNSI scale. The nutritional status was assessed using MNA score and PDQ-39 was used for assessing quality of life. Patients with and without neuropathy were compared to ascertain risk factors for neuropathy. Results: Twenty-four out of 93 PD patients (26%) had neuropathy and 12 (50%) out of them had painful neuropathy. Older patents and those who had longer duration of disease had higher prevalence of neuropathy. In addition there was significant correlation with malnutrition and neuropathy. 79% of patients with neuropathy had abnormal nutritional status. On comparison of patients with painful neuropathy as compared to those without pain, Vitamin B 12 levels were found to be low only in the former group. Conclusions: Our study shows that there is significant prevalence of neuropathy in PD patents that affects the quality of life of PD patients. Neuropathy in PD is disease dependent and is precipitated by malnutrition. Hence, neuropathy must be timely diagnosed and effective nutritional management may help to improve the patient's quality of life.

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Section: Discussionmentioning

confidence: 99%

Neuropathy in Parkinson's disease: Risk determinants and impact on quality of life

Ravi

Paul

Aggarwal

et al. 2022

Ann Indian Acad Neurol

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Estudo da neuropatia periférica em pacientes com doença de Parkinson: Revisão de literatura

Viana

Pereira

Vital

2021

RSD

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Nas últimas décadas, tem-se observado a presença de neuropatia periférica (NP) em pacientes com doença de Parkinson (DP), principalmente naqueles em tratamento crônico com levodopa (LD). A associação entre a NP e dose cumulativa de LD, os baixos níveis séricos de vitamina B12 e altos níveis plasmáticos de homocisteína e ácido metilmalônico tornaram-se evidentes. Objetivo: Identificar os fatores de risco relacionados a presença de Neuropatia periférica na Doença de Parkinson. Método: Utilizou-se as bases de dados Scielo, Pub Med e LILACS com as palavras-chave "Doença de Parkinson”, "neuropatia periférica”, “levodopa", "nervos periféricos” nos idiomas inglês, espanhol e português dos últimos 10 anos. Resultados: A maioria dos estudos de indivíduos com DP em uso crônico de LD, com altos níveis de ácido metilmalônico e homocisteína e deficiência de vitamina B12, apresentaram elevada prevalência de NP, predominando a forma sensório-motora com denervação axonal. Por outro lado, a presença de alfa sinucleina nos nervos periféricos pode determinar um processo degenerativo no sistema nervoso periférico. Conclusões: A neuropatia periférica em indivíduos com DP, além de relacionada a progressão e gravidade da doença, pode envolver outros fatores de risco como o uso prolongado de LD, deficiência de vitamina B12 e altos níveis séricos de homocisteína e ácido metilmalônico. A presença de alfa-sinucleina cutânea e nos nervos periféricos preconiza envolvimento no processo degenerativo periférico. Sugerem-se estudos prospectivos correlacionando o comprometimento do sistema nervoso periférico em pacientes com DP e o envolvimento de distintos fatores de risco com a progressão e agravamento da sintomatologia motora nesta doença.

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Parkinson-related neuropathy

Cited by 2 publications

References 28 publications

Neuropathy in Parkinson's disease: Risk determinants and impact on quality of life

Neuropathy in Parkinson's disease: Risk determinants and impact on quality of life

Estudo da neuropatia periférica em pacientes com doença de Parkinson: Revisão de literatura

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