Serum B Vitamin Levels and Risk of Lung Cancer

Abstract

Serum levels of vitamin B(6) and methionine were inversely associated with risk of lung cancer.

Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

“…The selection criteria of the EPIC lung cancer study have been described previously (20). In brief, the study included eight of the 10 participating countries: the Netherlands, the United Kingdom, France, Germany, Spain, Italy, Greece, and Sweden (except for Malm€ o center).…”

Biomarkers Related to One-Carbon Metabolism as Potential Risk Factors for Distal Colorectal Adenomas

“…This is underscored by the observed interactions of methionine with vitamin B2 and B6, which are biologically plausible because the transfer of methyl groups depends on the efficiency of enzymatic conversions. Investigating such interactions has not been common practice in epidemiological studies on colorectal carcinogenesis, although an interaction between serum levels of methionine and vitamin B6 has recently been reported in relation to lung cancer (41).…”

Literature search and review related to specific preparatory work in the establishment of Dietary Reference Values for Niacin, Biotin and Vitamin B6

“…Serum levels of vitamin B6 were inversely associated with the risk of lung cancer (OR 0.50; 95% CI 0.36-0.69; P trend <0.001 for highest (57.8-629 nmol/l) versus lowest quartile (5.7-28.4 nmol/l) ) in the complete study population. The association remained significant in strata of never and former smokers comparing the fourth quartile of serum levels with the first quartile (OR never 0.37; 95% CI 0.17-0.77; P trend =0.004; OR former 0.50; 95% CI 0.32-0.77; P trend =0.006), but were non-significant for current smokers (OR current 0.67; 0.42-1.06; P trend =0.04) (Johansson et al 2010).…”

“…Risk of bias in exposure assessment; high correlation between micronutrients in the diet (Chuang et al 2011, de Bree et al 2003, Eussen et al 2010a, Eussen et al 2010b, Folsom et al 1998, Hartman et al 2001, He et al 2004, Johansson et al 2010, Key et al 2012, Lin et al 2008, Page et al 2009.…”