Serum Antioxidants and Skin Cancer Risk: An 8-Year Community-Based Follow-up Study

Abstract

Background: Antioxidant nutrients can help prevent skin damage caused by ultraviolet radiation from sunlight, but it is not clear whether serum concentrations of such nutrients influence skin cancer risk. Methods: We carried out a prospective study of the associations between serum concentrations of antioxidant nutrients and incidence (person-based and tumorbased) of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin among a random subsample of 485 adults from an Australian community. Participants were divided into thirds, ranked according to their serum concentrations of carotenoids, A-tocopherol, and selenium measured in 1996 and were monitored for incident, histologically confirmed BCC and SCC tumors until 2004. Results: Although there were no associations between baseline serum carotenoids or A-tocopherol concentrations and incidence of BCC or SCC, baseline serum

Longitudinal Change in Diet Quality in Australian Adults Varies by Demographic, Socio-Economic, and Lifestyle Characteristics

“…For this study, we used data collected as part of the Nambour Skin Cancer Study, which involved a random, communitybased sample of Australian men and women. The design, study population, baseline data collection, and follow-up methods have previously been described in detail (18,19). In brief, participants were 1621 residents of the Nambour, a semirural township in Queensland, who were originally randomly selected from the electoral roll (voting is compulsory in Australia) (20) and participated in the Nambour Skin Cancer Prevention Trial (1992)(1993)(1994)(1995)(1996) and were followed up until 2007.…”

Dietary patterns and weight change: 15-year longitudinal study in Australian adults

“…The design, study population, baseline data collection, and follow-up methods have previously been described in detail [8,9]. In brief, participants were 1621 residents (88 % of 1850 persons invited) [8] of the Nambour township in Queensland, who were randomly selected from the electoral roll (voting is compulsory in Australia) [10] to participate in the Nambour Study and followed up between 1992 and 2007.…”

Selenium inhibits migration of murine melanoma cells via down-modulation of IL-18 expression

“…Recently, several studies have suggested that serum selenium level could be used as a prognostic marker in various cancer types, such as prostate, skin, breast and colon [34][35][36][37]. While studies suggest that selenium can help prevent cancer cell progression and may be useful as a diagnostic marker, it is not clear whether serum concentrations of selenium influence cancer progression.…”