Selenium inhibits migration of murine melanoma cells via down-modulation of IL-18 expression

Song, Han-Jung; Kim, Jiyoung; Lee, Hyun Kyung; Park, Hyun Jin; Nam, Joohyung; Park, Ga Bin; Kim, Yeong Seok; Cho, Daeho; Hur, Dae Young

doi:10.1016/j.intimp.2011.10.002

Cited by 28 publications

(15 citation statements)

References 33 publications

(36 reference statements)

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“…When mice were supplemented with high-Se isolated soy protein, significantly fewer mice developed extensive lung metastasis and the size of the metastases were reduced. Further studies revealed the mechanisms utilized by selenite to inhibit metastasis [71,72]. First, it appeared that murine melanoma cells, B16F10, were more resistant to selenite than other cancer cells.…”

Section: Melanomamentioning

confidence: 99%

Is Selenium a Potential Treatment for Cancer Metastasis?

2013

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Selenium (Se) is an essential micronutrient that functions as a redox gatekeeper through its incorporation into proteins to alleviate oxidative stress in cells. Although the epidemiological data are somewhat controversial, the results of many studies suggest that inorganic and organic forms of Se negatively affect cancer progression, and that several selenoproteins, such as GPXs, also play important roles in tumor development. Recently, a few scientists have examined the relationship between Se and metastasis, a late event in cancer progression, and have evaluated the potential of Se as an anti-angiogenesis or anti-metastasis agent. In this review, we present the current knowledge about Se compounds and selenoproteins, and their effects on the development of metastasis, with an emphasis on cell migration, invasion, and angiogenesis. In the cancers of breast, prostate, colorectal, fibrosarcoma, melanoma, liver, lung, oral squamous cell carcinoma, and brain glioma, there is either clinical evidence linking selenoproteins, such as thioredoxin reductase-1 to lymph node metastasis; in vitro studies indicating that Se compounds and selenoproteins inhibited cell motility, migration, and invasion, and reduced angiogenic factors in some of these cancer cells; or animal studies showing that Se supplementation resulted in reduced microvessel density and metastasis. Together, these data support the notion that Se may be an anti-metastastatic element in addition to being a cancer preventative agent.

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Section: Melanomamentioning

confidence: 99%

Is Selenium a Potential Treatment for Cancer Metastasis?

2013

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“…Song and colleagues and Jung and colleagues previously demonstrated that IL18 enhances the migration ability of murine melanoma cells (11,12). IL18 increased adherence to the microvascular walls and induced the production of angiogenic factors and tumor growth-stimulating factors.…”

Section: Introductionmentioning

confidence: 97%

Blocking NF-κB Is Essential for the Immunotherapeutic Effect of Recombinant IL18 in Pancreatic Cancer

Guo

Jiang

et al. 2016

Clinical Cancer Research

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Purpose: We sought to find new immune-based treatments for pancreatic cancer.Experimental Design: We detected IL18 expression in plasma and specimens from patients with pancreatic cancer. We then investigated whether IL18 had a therapeutic effect for pancreatic cancer in vitro and in vivo and any underlying mechanisms.Results: Higher plasma IL18 was associated with longer overall survival (OS), but higher IL18 in pancreatic cancer tissues was associated with shorter OS and increased invasion and metastasis. Recombinant IL18 alone had no antitumor effect in the syngeneic mice with orthotopically transplanted tumors and promoted tumors in immunocompromised mice; it also facilitated immune responses in vitro and in vivo by augmenting the activity of cytotoxic T cells and NK cells in peripheral blood and lymph nodes. However, IL18 promoted the proliferation and invasion of pancreatic cancer cells, in vitro and in vivo, through the NF-kB pathway. Nevertheless, by coadministrating IL18 with BAY11-7082, an NF-kB inhibitor, we were able to prevent the procancerous effects of IL18 and prolong the survival time of the mice.Conclusions: IL18 has both cancer-promoting and cancersuppressing functions. Although its single-agent treatment has no therapeutic effect on pancreatic cancer, when combined with the NF-kB pathway inhibitor, IL18 improved survival in a murine pancreatic cancer model. Our study implies the possibility of a combinational immunotherapy that uses IL18 and targets NF-kB pathway.

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“…It has been shown that berberine has anti-angiogenic effects in melanoma and it possibly acts through HIF-1α, VEGF and nitric oxide 67 . Selenium inhibits metastatic potential of murine melanoma cells and acts through inhibition of HIF-1α, VEGF and interleukin 18 68 . Vitamin K3 (menadione) attenuates self-ubiquitination of the seven in absentia homolog 2 (Siah2), increases expression of PHD3, thereby leading to decreased activity of HIF-1α and phosphorylated extracellular signal-regulated kinases.…”

Section: Introduction: Overview Of the Biology Of The Hypoxia-inducibmentioning

confidence: 99%

Putative role of HIF transcriptional activity in melanocytes and melanoma biology

Zbytek¹,

Peacock

Seagroves

et al. 2013

Dermato-Endocrinology

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Hypoxia-inducible factor-1α (HIF-1α) is a highly oxygen sensitive bHLH protein that is part of the heterodimeric HIF-1 transcription factor. Under hypoxic stress, HIF-1 activity is induced to control expression of multiple downstream target genes, including vascular endothelial growth factor (VEGF). The normal epidermis exists in a constant mild hypoxic microenvironment and constitutively expresses HIF-1α and HIF-2α. Expression of HIF-1α and/or HIF-2α has been suggested to correlate with the increased malignant potential of melanocytes, therefore, failures of melanoma therapies may be partially linked to high HIF activity. Notably, melanomas that have the V600E BRAF mutation exhibit increased HIF-1α expression. We have utilized a bioinformatics approach to identify putative hypoxia response elements (HREs) in a set of genes known to participate in the process of melanogenesis (includingTRPM1, SLC45A2, HRAS, C-KIT, PMEL and CRH). While some of the mechanistic links between these genes and the HIF pathway have been previously explored, others await further investigation. Although agents targeting HIF activity have been proposed as novel treatment modalities for melanoma, there are currently no clinical trials in progress to test their efficacy in melanoma.

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Selenium inhibits migration of murine melanoma cells via down-modulation of IL-18 expression

Cited by 28 publications

References 33 publications

Is Selenium a Potential Treatment for Cancer Metastasis?

Is Selenium a Potential Treatment for Cancer Metastasis?

Blocking NF-κB Is Essential for the Immunotherapeutic Effect of Recombinant IL18 in Pancreatic Cancer

Putative role of HIF transcriptional activity in melanocytes and melanoma biology

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