Serum Antinuclear Factor and the Influence of Environment in Mice

Barnes, R. D.; Tuffrey, Maureen

doi:10.1038/2141136a0

Cited by 20 publications

(5 citation statements)

References 5 publications

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“…C57Bl mice were selected because of their ability to form large amounts of antibody to tetanus toxoid (8) and because they occasionally develop antinuclear factor (9). C3H mice were used because they neither form excessive antibody to tetanus toxoid nor demonstrate antinuclear factor.…”

Section: Materials and Metkodsmentioning

confidence: 99%

Relative Inability to Induce Tolerance in Adult NZB and NZB/NZW F1 Mice

Staples

Talal

1969

The Journal of Experimental Medicine

129

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Immunologic tolerance to ultracentrifuged bovine gamma globulin could not be induced in 6-wk old NZB or B/W mice, but developed readily in C3H, NZW, and C57Bl mice. NZB and B/W mice, as well as Balb/c mice, failed to become tolerant to ultracentrifuged human gamma globulin. The NZB and B/W mice also showed higher antibody titers to a standard antigenic challenge. This immunologic hyperreactivity and lack of experimental tolerance may be related to the lack of self-tolerance, autoimmunity, and lymphomas that develop in these mice at a later age.

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Section: Materials and Metkodsmentioning

confidence: 99%

Relative Inability to Induce Tolerance in Adult NZB and NZB/NZW F1 Mice

Staples

Talal

1969

The Journal of Experimental Medicine

129

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“…1) Spontaneous appearance of ANF: The appearance of ANF could be spontaneous and not actually related to alloimmunization. For example, ANF incidence increases with age in many but not all inbred strains of mice (Barnes & Tuffrey 1967, Friou & Teague 1964, Norins & Holmes 1967, Siege1 et al 1972, Yunis et al 1972. For most of the antisera in Table 1 the age of the recipient is unknown, and conceivable ANF might appear in some antisera simply by virtue of the fact that the recipient mice were aging and would have produced ANF whether or not they had been alloimmunized.…”

Section: Discussionmentioning

confidence: 99%

Antinuclear factors in murine alloantisera

1981

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We have demonstrated that anti-Thy 1.1 and certain of H-2 alloantisera contain an antinuclear factor (ANF) detected by fluorescent antimouse IgG. The incidence of ANF positive antisera that we report may actually be an underestimate. ANF is present in sera not only from our laboratory but also from other sources; thus ANF is not an artifact of our laboratory. ANF is not identical to alloantibody, and the ANF appears to be of an autoimmune nature. A variety of environmental and genetic factors may influence the appearance of ANF in anti-H-2 sera, but we believe that the consistent detection of ANF in sera directed against H-2.31,34 or against H-2.4 suggest that some specific aspect of immune stimulation by these H-2 antigens, and likely by other H-2 antigenic specifications, induces the appearance of ANF. It is not known whether it is these K and D antigens or other determinants associated with the H-2 complex that may actually provide the immune stimulation for ANF induction. The particular mechanisms that may be operating to induce ANF cannot be determined at present. We are continuing with experiments to define what parameters influence the appearance of ANF in alloantisera.

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“…Perhaps more important is that more female chimaeric F1 offspring were examined since female NZB x CFW hybrids are known to have a greater incidence of ANA (Barnes et al, 1968). Environmental factors also influence the incidence of ANA (Barnes and Tuffrey, 1967) and might have also contributed to the variation between the two groups. However, as in the natural NZB and (NZBxCFW) F l situation (Barnes et al, 1968) the incidence of ANA in the chimaeras' NZB offspring was less than that in the corresponding hybrid.…”

Section: Discussionmentioning

confidence: 99%