NZB thymus chamber implantation 519 Fourth, the kinetics of responses against H-2 alloantigens were different in the two systems. Mouse serum extended reactivity of the responder cells such that peak incorporation was exhibited approximately 30 h after the peak response in the absence of serum (98 vs. 66 h). However, during the first 60-70 h of culture, the responses of the two systems paralleled each other.These findings also raise two major questions: 1) what is the mode of action of 2-ME that enhances the immune reactivity of lymphoid cells against alloantigens in the MLI (see ref. [4]; and 2) by what means does mouse serum, or a specific component of this serum, i.e. MSF-1 [2], affect either the responder or stimulator cells and enhance the
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