Serum Angiotensin-Converting Enzyme in Patients Suffering from Multiple Sclerosis and Healthy Controls: a Pilot Study

Razazian, Nazanin; Almasi, Vahid; Afshari, Darioush; Bostani, Arash; Moradian, Nasrin; Farahvashi, M.

doi:10.1007/s11062-019-09760-5

Cited by 5 publications

(9 citation statements)

References 8 publications

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“…For example, Razazian et al analyzed serum ACE levels in 30 patients diagnosed with MS in a pilot study and did not find any significant differences compared with 30 healthy controls. These inconsistent results were explained by the authors to be probably due to the difference between serum and CSF properties, ACE activity and ACE levels, or differences between the laboratory techniques used [ 120 ].…”

Section: Renin-angiotensin-aldosterone System and Multiple Sclerosismentioning

confidence: 99%

Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases

et al. 2022

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Brain neurodegenerative diseases (BND) are debilitating conditions that are especially characteristic of a certain period of life and considered major threats to human health. Current treatments are limited, meaning that there is a challenge in developing new options that can efficiently tackle the different components and pathophysiological processes of these conditions. The renin-angiotensin-aldosterone system (RAS) is an endocrine axis with important peripheral physiological functions such as blood pressure and cardiovascular homeostasis, as well as water and sodium balance and systemic vascular resistance—functions which are well-documented. However, recent work has highlighted the paracrine and autocrine functions of RAS in different tissues, including the central nervous system (CNS). It is known that RAS hyperactivation has pro-inflammatory and pro-oxidant effects, thus suggesting that its pharmacological modulation could be used in the management of these conditions. The present paper underlines the involvement of RAS and its components in the pathophysiology of BNDs such as Parkinson’s disease (PD), Alzheimer’s disease (AD), multiple sclerosis (MS), Huntington’s disease (HD), motor neuron disease (MND), and prion disease (PRD), as well as the identification of drugs and pharmacologically active substances that act upon RAS, which could alleviate their symptomatology or evolution, and thus, contribute to novel therapeutic approaches.

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Section: Renin-angiotensin-aldosterone System and Multiple Sclerosismentioning

confidence: 99%

Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases

et al. 2022

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“…The protective axis consists of angiotensin 1-7 (Ang1-7)/ACE2/Mas receptor (MasR), and sometimes angiotensin type 2 receptor (AT2R) is also taken into account in this axis. Angiotensin-converting enzyme 2 produces Ang1-7 via catalyzing Ang II [240,242,243].…”

Section: Respiratory Dysfunctions Common Road Between Coronavirus And...mentioning

confidence: 99%

“…However, ACE belongs to RAS. RAS comprises two arms or axes in which one of them is detrimental/pathological and another is protective with opposing effects [ 240 , 241 ]. The main pathological axes are angiotensin II (Ang II also known as Ang1-8)/ACE/angiotensin type 1 receptor (AT1R).…”

Section: Introductionmentioning

confidence: 99%

“…The protective axis consists of angiotensin 1–7 (Ang1-7)/ACE2/Mas receptor (MasR), and sometimes angiotensin type 2 receptor (AT2R) is also taken into account in this axis. Angiotensin-converting enzyme 2 produces Ang1-7 via catalyzing Ang II [ 240 , 242 , 243 ]. The second axis has anti-inflammatory, anti-proliferative, anti-fibrotic, anti-apoptotic, and vasodilatory functions [ 244 ].…”

Section: Introductionmentioning

confidence: 99%

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Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise

et al. 2022

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Coronavirus disease-2019 (COVID-19) is associated with cytokine storm and is characterized by acute respiratory distress syndrome (ARDS) and pneumonia problems. The respiratory system is a place of inappropriate activation of the immune system in people with multiple sclerosis (MS), and this may cause damage to the lung and worsen both MS and infections.The concerns for patients with multiple sclerosis are because of an enhance risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The MS patients pose challenges in this pandemic situation, because of the regulatory defect of autoreactivity of the immune system and neurological and respiratory tract symptoms. In this review, we first indicate respiratory issues associated with both diseases. Then, the main mechanisms inducing lung damages and also impairing the respiratory muscles in individuals with both diseases is discussed. At the end, the leading role of physical exercise on mitigating respiratory issues inducing mechanisms is meticulously evaluated.

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“…In addition to that, Ang II up-regulation in astrocytes plays an important role in deteriorating the in ammatory pathogenesis of MS (14,18,19). A study has shown that Angiotensin-converting enzyme (ACE) level was higher in patients diagnosed with MS compared to healthy subjects (20). Moreover, our previous study demonstrated that the mean serum ACE level was remarkably increased in idiopathic acute ON patients compared to the control group (21).…”

Section: Introductionmentioning

confidence: 99%

Is serum angiotensin-converting enzyme a suitable biomarker for differentiating idiopathic and demyelinating optic neuritis?

Dehghani,

Hosseini,

Irajpour

et al. 2023

Preprint

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Background: To measure serum angiotensin-converting enzyme (ACE) in patients diagnosed with idiopathic and demyelinating optic neuritis (ON) as well as heathy individuals and assess its viability as a biomarker Methods: This case-control study involved patients with established acute ON as a study group and healthy controls aged between 18 and 50 years. After systemic and neurological evaluation, the study group was divided into two subgroups: idiopathic ON and demyelinating ON, including Multiple Sclerosis (MS), Neuromyelitis Optica (NMO) and clinically isolated syndrome (CIS). Using enzyme-linked immunosorbent assay, serum ACE levels were obtained and compared between groups. Results: Fifty-one patients with acute optic neuritis (78.4% female, mean age 29.8 ± 8.4 years) and 51 controls (78.4% female, mean age 29.9 ± 6.9 years) were recruited. In the study group, 29 patients were diagnosed with idiopathic ON (56.9%), and 22 patients with demyelinating ON (43.1%) (MS-ON, n=16; NMO-ON, n=3; and clinically isolated syndrome, n=3). The median serum ACE levels were 33.50 U/L (range: 29.40–46.20) and 34.25 U/L (range: 29.30–46.10) for patients diagnosed with idiopathic ON and demyelinating ON, respectively (P>0.99). Mean serum ACE level for healthy individuals was 26.2 U/L (range: 24.80–20.50) and compared to other groups it was significantly different (P<0.001). A high level of serum ACE (defined as a serum ACE >65 U/L) was present in 3 (10.3%) patients with idiopathic ON and 2 (9.1%) patients with the demyelinating ON (P>0.99). Conclusions: These results reveal that serum ACE levels are not significantly different in patients diagnosed with idiopathic ON and demyelinating ON. But serum ACE level in both groups is significantly higher compared to healthy subjects.

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Serum Angiotensin-Converting Enzyme in Patients Suffering from Multiple Sclerosis and Healthy Controls: a Pilot Study

Cited by 5 publications

References 8 publications

Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases

Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases

Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise

Is serum angiotensin-converting enzyme a suitable biomarker for differentiating idiopathic and demyelinating optic neuritis?

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