Serum angiopoietin‐2 level as a novel biomarker in atopic dermatitis

Khattab, Fathia M; Said, Noha Mohamed

doi:10.1111/ijd.14620

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…This was in accordance with Takahashi et al 11 who reported after analyzing patients with psoriasis that there was a significant relation between ANG‐2 serum level and score of PASI ( P = .011) and with Khattab & Said 12 who stated that both disease severity and SCORAD score in atopic dermatitis patients showed a positive significant relation between disease severity and serum Ang‐2 levels ( P = .001). In other words, a higher disease extent might account for a greater change in ANG‐2 as an important mediator in disease pathogenesis and severity.…”

Section: Discussionsupporting

confidence: 90%

Serum angiopoietin‐2 level as a novel potential biomarker in oral lichen planus

Bessar

Hammad

Ismail

et al. 2021

J of Cosmetic Dermatology

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Background Lichen planus is a common chronic cutaneous inflammatory disease. Recent advances evidenced that angiogenesis is tightly connected to it. More recently, the endothelial specific growth factor angiopoietin‐2 has been clarified to interact with vascular endothelial growth factor. Angiopoietin‐2 level has not been investigated in lichen planus. Aim To evaluate serum level of angiopoietin‐2 in cutaneous and oral lichen planus. Methods Ninety patients were investigated, 45 patients with lichen planus. In addition to forty‐five healthy control, the activity of the disease was estimated at the time of examination. The serum level of angiopoietin‐2 had been estimated by enzyme‐linked immunosorbent assay. The relationships between angiopoietin‐2 serum level and disease severity, type of lichen, and visual analogue scale score (VAS) were determined. Results The serum levels of angiopoietin‐2 were substantially higher in patients with both cutaneous and oral lesions than patients with cutaneous lichen planus only (P < .001). Conclusions Serum angiopoietin‐2 is elevated in patients compared with normal subjects and is correlated with the presence of oral lesions and disease severity, that reflects its role in angiogenesis and inflammation, and angiopoietin‐2 serum level could be a potential marker for monitoring the oral lichen to identify possible malignant transformation.

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Section: Discussionsupporting

confidence: 90%

Serum angiopoietin‐2 level as a novel potential biomarker in oral lichen planus

Bessar

Hammad

Ismail

et al. 2021

J of Cosmetic Dermatology

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“…Furthermore, Ang‐2 was positively correlated with disease severity in HS patients. In this regard, a positive correlation between serum Ang‐2 levels and disease severity has also been found in other dermatological diseases such as psoriasis 11 and atopic dermatitis 12 . Since the correlation between Ang‐2 and CV disease is well known, the results of our study might indicate that high levels of Ang‐2 could play a role in the CV burden of HS.…”

Section: Discussionsupporting

confidence: 76%

Biomarkers of endothelial dysfunction and atherosclerosis in hidradenitis suppurativa

González‐López

Ocejo‐Viñals

López-Sundh

et al. 2022

The Journal of Dermatology

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Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with an increased prevalence of subclinical atherosclerosis and cardiovascular risk. Angiopoietin-2 (Ang-2), asymmetric dimethylarginine (ADMA), and osteoprotegerin (OPG) are molecules related to endothelial dysfunction (ED) and atherosclerosis, but also to disease severity in patients with chronic inflammatory disorders. In this case-control study, we aimed to investigate serum Ang-2, ADMA, and OPG levels in patients with HS, and to assess the potential relationship between these levels and disease severity. Seventy-five patients with HS and 60 controls were assessed. Serum Ang-2, ADMA, and OPG concentrations were determined in all participants. HS patients had significantly higher Ang-2 and ADMA levels than controls after adjusting for confounders. Besides, Ang-2 concentrations positively correlated with disease severity in the adjusted multivariable analysis.Nevertheless, serum OPG levels did not significantly differ between HS patients and controls. Our results indicate that serum Ang-2 and ADMA levels are significantly increased in patients with HS. Furthermore, Ang-2 might be a suitable marker of HS severity.

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“…8 Khattab and Said reported that Ang-2 is upregulated in sera of atopic dermatitis patients and positively correlated its levels to disease severity. 9 To our knowledge, the current study was the first to assess Ang-2 serum levels following phototherapy. After treatment, there was a statistically significant decrease in the Ang-2 level in psoriatic patients from (1.13 ± 0.78) before intervention to (0.51 ± 0.22) after intervention (p < 0.001).…”

Section: Ta B L E 1 Baseline Characteristics Of Studied Group (N = 76)mentioning

confidence: 90%

Implications of narrowband ultraviolet B treatment on psoriasis severity and serum levels of angiopoietin‐2: A cross‐sectional controlled study

Nada

Elshabrawy

Elenain

et al. 2021

J of Cosmetic Dermatology

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Background Psoriasis is a chronic inflammatory hyper proliferative skin disease. Angiogenesis play an important role in Psoriasis pathogenesis, occurring even before plaque formation. Angiopoietins play an important role in angiogenesis and hence are described as angiogenic factors. Aims To evaluate serum levels of angiopoeitin 2 (Ang‐2) following treatment with narrowband ultraviolet B (NBUVB) in patients with moderate‐severe plaque psoriasis and correlate it to psoriasis area and severity index (PASI). Patients/Methods This cross sectional study included 38 patients complaining of moderate to severe plaque psoriasis and 38 healthy controls. Psoriasis area and severity index (PASI) was determined and was correlated to serum levels of Ang‐2 before and after treatment with NBUVB. Results PASI scores and serum values of angiopoietin 2 demonstrated a significant difference between the baseline and at the end of the 12 weeks NBUVB treatment. A statistically significant positive correlation was established between psoriasis severity and Ang‐2 serum levels before and after treatment. Conclusion The study demonstrated a potential contribution of Ang‐2 in the pathogenesis of psoriasis, as well as its usefulness as a biomarker of psoriasis severity.

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Serum angiopoietin‐2 level as a novel biomarker in atopic dermatitis

Cited by 6 publications

References 16 publications

Serum angiopoietin‐2 level as a novel potential biomarker in oral lichen planus

Serum angiopoietin‐2 level as a novel potential biomarker in oral lichen planus

Biomarkers of endothelial dysfunction and atherosclerosis in hidradenitis suppurativa

Implications of narrowband ultraviolet B treatment on psoriasis severity and serum levels of angiopoietin‐2: A cross‐sectional controlled study

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