Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: Part A. Serum androgen levels in women aged 20–49 years with no complaints of sexual dysfunction

Guay, André T.; Munárriz, Ricardo; Jacobson, Jerilynn; Talakoub, Lily; Traish, Abdulmaged M.; Quirk, Frances; Goldstein, Irwin; Spark, Richard F.

doi:10.1038/sj.ijir.3901178

Cited by 63 publications

(59 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Androgen signaling in female is very important for the differentiation of human endometrial stromal cells into decidual cell; a process is called decidualization that critically controls embryo implantation and placentation [11]. The effect of androgens such as testosterone and dihydrotestosterone mediated by androgen receptor (AR) that is a nuclear receptor [3].…”

Section: Introductionmentioning

confidence: 99%

StuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion

Jahaninejad

Ghasemi

Kalantar

et al. 2013

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose This is a case-control study to determine whether G1733A polymorphism of androgen receptor gene is associated with an increased risk for recurrent spontaneous abortion (RSA). Method A total of 85 women with at least two recurrent spontaneous abortion before 20th week of gestation composed the study group. Subjects were genotyped by the polymerase chain reaction restriction fragment length polymorphism method. Results The observed frequencies of GG, GA and AA genotypes of the G1733A polymorphism were 5.89 %, 82.35 % and 11.76 %, respectively, for the patient group and 71.76 %, 23.51 % and 4.71 %, respectively, for the control group. Allele frequencies of the G1733A polymorphism among patients and controls were 0.47 and 0.84, respectively, for the dominant allele (G) (wild type) and 0.53 and 0.16, respectively, for the A allele (mutant type). Conclusions These results indicated that the androgen receptor G1733A polymorphism is strongly associated with increased risk for RSA.Keywords Recurrent spontaneous abortion . Androgen receptor . Polymorphism . RFLP PCR Recurrent spontaneous abortion (RSA) is a reproductive problem that occurs in women in reproductive age with a frequency of 1 %-3 % [20]. It is defined as two or more repeated pregnancy losses before the 20th week of gestation [14]. The risk of miscarriage is enhanced by a variety of factors including chromosomal abnormalities, uterine abnormalities, hereditary thrombophilia, endocrinologic disorders,-immunologic factors, infections, and nutritional and environmental factors [18,19]. In women with a history of recurrent miscarriage, the risk of miscarriage in a subsequent pregnancy is about 40 % to 50 %. It has a major influence on the wellbeing and psychological status of patients, therefore improved diagnosis and development of treatment strategies is essential [6,16,23]. In the past years, research interest has been focused on the association studies between different genetic polymorphisms and recurrent spontaneous abortion.Androgens are lipophilic hormones with several physiological effects in both sexes [17]. Androgen signaling in female is very important for the differentiation of human endometrial stromal cells into decidual cell; a process is called decidualization that critically controls embryo implantation and placentation [11]. The effect of androgens such as testosterone and dihydrotestosterone mediated by androgen receptor (AR) that is a nuclear receptor [3]. Androgen receptor is widely expressed in female reproductive tissue such as endometrium [1] and binds to a steroid ligand and then is transferred into the nucleus, where it regulates the transcription of androgen-responsive genes [5]. The AR gene is located on the X chromosome between q11 and q12 loci and is composed of eight exons [2] that encode a 110-kd protein that contains an N-terminal transactivation domain, Capsule Our results indicated that the androgen receptor G1733A polymorphism is strongly associated with increased risk for RSA.T. Jahaninejad (*) :

show abstract

Section: Introductionmentioning

confidence: 99%

StuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion

Jahaninejad

Ghasemi

Kalantar

et al. 2013

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…There was no change in sex hormonebinding globulin. 41 Another study of 1423 women between 18 and 75 years old found similar decreases in premenopausal women, with no further decreases post-menopausally. 42 Several studies have evaluated androgen levels in women with HSDD, and these provide no definitive evidence of lower levels in HSDD compared to normal women.…”

Section: Androgens In Hypoactive Sexual Desire Disorder In Womenmentioning

confidence: 89%

‘Off-label’ drug use in sexual medicine treatment

Fallon

2007

Int J Impot Res

View full text Add to dashboard Cite

Phosphodiesterase type 5 inhibitors are the only drugs approved for a specific sexual function disorder. All other drugs used in the treatment of sexual disorders are used 'off-label.' This paper reviews the use of drugs in the treatment of premature ejaculation, Peyronie's disease and female hypoactive sexual desire disorder (HSDD). While the treatment of premature ejaculation is quite well documented and supported by evidence of good quality in the medical literature, there is little evidence for the use of the variety of medications in use for the treatment of Peyronie's disease. In particular, the use of verapamil is not supported by any double-blind studies whatsoever. The use of testosterone patch for treatment of HSDD in postmenopausal women is well documented, but not in premenopausal women.

show abstract

“…La fisiología de la respuesta sexual viene extensamente descrita en los múltiples trabajos del Dr. Mas [38][39][40][41] . A continuación expondré un resumen orientado a ver qué aspectos de la fisiología de la RS pueden verse afectados por la histerectomía.…”

Section: Fisiología De La Respuesta Sexual Femeninaunclassified

“…Los ovarios y las glándulas suprarrenales comparten la producción de testosterona a partes iguales. Hay una disminución en la producción progresiva con la edad 38 . La insuficiencia de andrógenos es una causa reconocida de disfunción sexual.…”

Section: Fisiología De La Respuesta Sexual Femeninaunclassified

“…Se asocia con diminución de la libido, pérdida de la respuesta sexual ante estímulos, incluso empeoramiento de la congestión vulvar y vaginal. Las mujeres premenopáusicas con quejas sobre su función sexual tienen menos niveles de precursores androgénicos adrenales y testosterona que aquellas de la misma edad sin quejas 38 .…”

Section: Fisiología De La Respuesta Sexual Femeninaunclassified

See 1 more Smart Citation

Función Sexual Tras 9 Meses De Una Histerectomía : Comparación De Los Resultados Del Cuestionario De Salud Sexual Fsm® Versus Percepción Subjetiva De La Mujer

Parra¹,

Merlo²,

Mirasol³

et al. 2017

View full text Add to dashboard Cite

Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: Part A. Serum androgen levels in women aged 20–49 years with no complaints of sexual dysfunction

Cited by 63 publications

References 24 publications

StuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion

StuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion

‘Off-label’ drug use in sexual medicine treatment

Función Sexual Tras 9 Meses De Una Histerectomía : Comparación De Los Resultados Del Cuestionario De Salud Sexual Fsm® Versus Percepción Subjetiva De La Mujer

Contact Info

Product

Resources

About