Serum and Urinary Uric Acid in Primary Hyperparathyroidism

Yamamoto, Shozo; Hiraishi, Koji; Nakamura, Shōichirō; Ghazizadeh, Mohammad

doi:10.1111/j.1464-410x.1987.tb04831.x

Cited by 4 publications

(6 citation statements)

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“…While studies using a follow-up time of several months after surgery for HPT have demonstrated a reduction in serum urate levels (Ljunghall and Akerström, 1982;Castrillo et al, 1984;Quang-Yang et al, 1986) due to an increased renal clearence of urate (Ljunghall and Akerström, 1982), serum urate was unaffected during the first postoperative week in this study. This is in accordance with a report (Yamamoto et al, 1987) in which serum urate was found not to be influenced by surgery up to one month postoperatively.…”

Section: Discussionsupporting

confidence: 93%

Serum Urate and Renal Function in Different Forms of Hypercalcemia

Lind¹,

Ljunghall²

2009

Exp Clin Endocrinol Diabetes

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In order to investigate the relationships between serum calcium, urate and kidney function, serum calcium, urate, creatinine and urea were measured at 100 occasions in hypercalcemic cancer patients together with 113 preoperative measurements in HPT subjects and 106 measurements in normocalcemic control persons. When compared to normocalcemic control subjects (serum urate 336 +/- 110 mumol/l) both HPT subjects (356 +/- 98 mmol/1, p less than 0.006) and the cancer patients (407 +/- 179 mmol/l, p less than 0.001) showed raised levels of serum urate. While serum urate was correlated to serum creatinine in all groups (r = 0.40-0.59, p less than 0.0001) a significant correlation to serum calcium was only seen in the HPT group (r = 0.28, p less than 0.004). This relation persisted also after correction for age, sex and serum creatinine in the multiple regression analysis. Serum creatinine was similar in all groups but significantly correlated to serum calcium only in the HPT subjects (r = 0.29, p less than 0.003). Serum urea was not significantly correlated to serum calcium in any of the groups but was elevated in the cancer group (8.3 +/- 4.4 vs 6.2 +/- 2.9 mumol/l in the control group, p less than 0.0001). This elevation in serum urea seen in the cancer patients might rather be explained by dehydration or catabolism than an impaired kidney function. In conclusion, while serum urate is related to the kidney function both in normo- and hypercalcemia, it also seems to be related to the hypercalcemia in HPT subjects but not in cancer patients.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 93%

Serum Urate and Renal Function in Different Forms of Hypercalcemia

Lind¹,

Ljunghall²

2009

Exp Clin Endocrinol Diabetes

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“…A total of 61 articles were excluded at this stage as they did not report the outcomes of interest. Finally, nine cohort studies were included into the meta‐analysis . The study review and selection process are described in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…Finally, nine cohort studies were included into the meta-analysis. [13][14][15][16][17][18][19][20][21] The study review and selection process are described in Figure 1. The basic characteristics of all included studies are summarized in Table 1.…”

Section: Search Resultsmentioning

confidence: 99%

“…F I G U R E 1 Study identification and literature review process TA B L E 1 Main characteristics of the studies included in the meta-analysis Broulik et al 13 Yamamoto et al 14 16 Delfini et al 17 Cases: Cases were patients with PHPT proven by histopathology after surgery who were recruited from the Endocrine Institute, Haemek Medical Center, Afula, Israel. Controls: Controls were age-and BMI-matched subjects without PHPT who were recruited from community-based health centers of the same geographic area.…”

Section: Discussionmentioning

confidence: 99%

“…This observation may have some clinical implications for the management of hyperuricemia.For instance, similar to other causes of secondary hyperuricemia, PHPT may be considered as a treatable/modifiable cause of hyperuricemia. In fact, a number of studies have demonstrated a reduction in levels of serum uric acid in patients with PHPT after parathyroidectomy [8][9][10][13][14][15][19][20]…”

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confidence: 99%

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Primary hyperparathyroidism is associated with a higher level of serum uric acid: A systematic review and meta‐analysis

2019

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Objectives Studies have suggested that primary hyperparathyroidism could be a risk factor for hyperuricemia although the results were not consistent across the studies. This systematic review and meta‐analysis was performed in order to identify all available studies and summarize their results together. Methods A systematic review was performed using EMBASE and MEDLINE from inception to August 2018 to identify all cohort studies that consisted of 2 cohorts, a cohort of patients with primary hyperparathyroidism and a cohort of individuals without hyperparathyroidism. Eligible studies had to provide data on mean serum uric acid level and standard deviation of both cohorts, which would be extracted to calculate mean difference (MD). Pooled MD was then calculated by combining MDs of each study using a random‐effects model. Funnel plot was used for evaluation for publication bias. Results A total of 9 cohort studies met the inclusion criteria and were included into the meta‐analysis. The pooled analysis found that patients with primary hyperparathyroidism had a significantly higher level of serum uric acid than individuals without hyperparathyroidism with the pooled MD of 65.00 μmol/L (95% CI 37.74‐92.25). The statistical heterogeneity was high with I2 of 90%. The funnel plot was relatively symmetric and did not provide evidence for publication bias. Conclusion Patients with primary hyperparathyroidism had a significantly higher level of serum uric acid compared to individuals without hyperparathyroidism.

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