Serum and urinary soluble α-Klotho levels in patients with chronic kidney disease

Al-Jewari, Khalid; Baban, Rayah S.; Manuti, Jawad K.

doi:10.47419/bjbabs.v2i01.35

Cited by 3 publications

(3 citation statements)

References 16 publications

(12 reference statements)

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“…Immunization is one of the programs being used as an indicator of minimum service standards in the health sector. The implementation of immunization is regulated by the Regulation of the Minister of Health Number 12 of 2017 and Number 4 of 2019, under which immunization services must be carried out completely and precisely according to the standards [8][9][10][11][12][13][14][15][16]. Indonesian policy requires every baby (aged 0 -11 months) to receive complete basic immunization (CBI) consisting of 1 dose of Hepatitis B, one dose of BCG, three doses of DPT-HB-HiB, four doses of polio drop, and one dose of measles/MR.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

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Section: Introductionmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

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“…Since its appearance in Wuhan, China, in December 2019, the corona-19 virus (Covid- 19) has rapidly spread globally [1][2][3]. There have not been adequate studies on the immunological response to COVID-19 infection, and it is unclear if people who have recovered from the virus will become infected again.…”

Section: Introductionmentioning

confidence: 99%

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Army¹,

Violetta²

2022

J. Med. Chem. Sci.

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The Corona-19 virus disease continues to cause an increasing number of deaths, mainly due to acute respiratory disorders. The high pandemic mortality and morbidity prompted clinicians to seek suitable adjunctive therapeutic methods to eliminate high cytokine levels effectively. This study aimed to review the combined plasma filtration adsorption (CPFA) technology and its potential efficacy in treating critically ill Covid-19. CPFA combines plasma separation, adsorption, and hemofiltration techniques that meet the need to remove substances such as cytokines. Findings from the report suggest an immune dysregulation known as cytokine storm syndrome plays a role in severe and critically ill Covid-19 patients. Extracorporeal blood purification targets cytokine elimination and is preferred as a bridging strategy to improve survival. Combined adsorption plasma filtration (CPFA) can remove various substances, including cytokines, without depleting physiologically essential proteins. CPFA can be considered and assessed in clinical trials to treat critically ill Covid-19 patients. Paired Plasma Filtration Adsorption (PPFA) can be viewed as a potentially effective therapy in treating Covid-19 patients in critical condition.

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“…It has been reported that the risk factors for chronic kidney disease were age, race, obesity, diabetes, low birth weight, high blood pressure, and family history [ 14 ]. The risk of CKD morbidity and mortality remains considerably high, with CKD patients usually receiving renal replacement therapy, such as dialysis and kidney transplantation.…”

Section: Introductionmentioning

confidence: 99%

Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris

Yang

Kuo

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Chronic kidney disease (CKD) is a critical public health issue with a huge financial burden for both patients and society worldwide. Unfortunately, there are currently no efficacious therapies to prevent or delay the progression of end-stage renal disease (ESRD). Traditional Chinese medicine practices have shown that Cordyceps militaris (C. militaris) mycelia have a variety of pharmacologically useful properties, including antitumor, immunomodulation, and hepatoprotection. However, the effect of mycelial C. militaris on CKD remains unclear. Methods. Here, we investigated the effects of C. militaris mycelia on mice with CKD using four types of media: HKS, HKS with vitamin A (HKS + A), CM, and CM with vitamin A (CM + A). Results. The results at day 10 revealed that the levels of blood urea nitrogen (BUN) were significantly lower in the HKS (41%), HKS + A (41%), and CM + A (34%) groups compared with those in the corresponding control groups (nephrectomic mice). The level of serum creatinine in the HKS + A group decreased by 35% at day 10, whereas the levels in the HKS and CM + A groups decreased only by 14% and 13%, respectively, on day 30. Taken together, this is the first report using four new media (HKS, HKS + A, CM, and CM + A medium) for C. militaris mycelia. Each medium of mycelial C. militaris on CKD exhibits specific effect on BUN, serum creatinine, body weight, total protein, and uric acid. Conclusions. Taken together, this is the first report using four new media (HKS, HKS + A, CM, and CM + A medium) for C. militaris mycelia. Each medium of mycelial C. militaris on CKD exhibits specific effects on BUN, serum creatinine, body weight, total protein, and uric acid. We concluded that treatment with C. militaris mycelia cultured in HKS or CM + A medium could potentially prevent the deterioration of kidney function in mice with CKD.

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Serum and urinary soluble α-Klotho levels in patients with chronic kidney disease

Cited by 3 publications

References 16 publications

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Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris

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