Serum and Urinary Orosomucoid in Young Patients With Type 1 Diabetes

Abstract

Orosomucoid is an acute-phase serum protein that is upregulated in urine samples of patients with diabetic nephropathy. We assessed serum and urinary orosomucoid levels in children and adolescents with type 1 diabetes and their relation to microvascular complications and carotid intima-media thickness (CIMT). Sixty patients with type 1 diabetes were divided into 2 groups according to the presence of microvascular complications and compared with 60 healthy controls. High-sensitivity C-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), urinary albumin-creatinine ratio (UACR), serum and urinary orosomucoid, and CIMT were assessed. Both serum and urinary orosomucoid levels were significantly increased in patients with and without microvascular complications compared with controls, and the highest levels were in patients with complications (P < .001). Serum and urinary orosomucoid were higher in patients with microalbuminuria than normoalbuminuric group (P < .001). The cutoff value of urinary orosomucoid at 2825 ng/mL could differentiate patients with and without microvascular complications. Serum and urinary orosomucoid were positively correlated. Multiple regression analysis showed that HbA1c, UACR, hs-CRP, and CIMT were independently related to orosomucoid. We suggest that orosomucoid is a significant independent factor for diabetic microvascular complications and can be considered as an early marker of renal injury. High orosomucoid levels in type 1 diabetes reflect endothelial dysfunction and subclinical atherosclerosis.

Urinary Orosomucoid A Potential Marker Of Inflammation In Psoriasis

“…Previous studies showed excessive u-ORM excretion in several chronic and acute inflammatory conditions 17 - 20 . Moderate elevation of u-ORM levels were found in diabetes mellitus and also in cardiovascular diseases, presumably associated with chronic low grade inflammation, endothelial dysfunction and oxidative stress which are also pathophysiologic factors in psoriasis 8 , 22 , 27 - 30 .…”

Estrogen weakens muscle endurance via estrogen receptor-p38 MAPK-mediated orosomucoid (ORM) suppression

“…ORM exhibits many biological activities, including modulating immunity, binding and carrying drugs, maintaining the capillary barrier and acting as a disease marker. 17 The role of ORM in cancer, 18 , 19 , 20 cardiovascular diseases 21 , 22 and energy metabolism 23 was revealed recently. We previously reported that ORM was significantly elevated in the sera, liver and muscle tissues of fatigued rodents (for example, sleep-deprivation, forced swimming and treadmill-running models) and the sera of chronic fatigue syndrome patients.…”

Diabetic Retinopathy: Changes in Levels of Orosomucoids in Patients Supplemented with Beta Glucan and Vitamin D

“…ORM1 is assumed to play a role in induction of cancer development and is involved in regulation of angiogenesis (Muhammad et al, 2017). We based our study of ORM in DM2 on published findings of relation between ORM and DM1 (El-Beblawy et al, 2016). Our data showed that evaluation of serum levels of ORM and its dynamics related to DM complication is valuable.…”

“…Diabetic patients are endangered by various complications, influencing the quality of their life functions. Diabetic Retinopathy (DR) holds the most common complications of DM with current prevalence reaching more than 10 million wordwide (El-Beblawy et al, 2016). Regulation of immune functions and control of inflammatory processes are decisive in maintaining normal retinal functions.…”

“…This high risk of diabetes related to high levels of acute inflammatory protein can be accepted with one condition: additional possible mechanisms involved must be evaluated and described (Muhammad et al, 2017). High ORM levels on DM1 reflect endothelial dysfunction and subclinical atherosclerosis and can be considered as an early marker of renal injury (El-Beblawy et al, 2016). ORM can regulate food intake and homeostasis of energy .…”