Urinary Orosomucoid A Potential Marker Of Inflammation In Psoriasis

Kabos, Peter; Kőszegi, Tamás; Miseta, Attila; Péter, Iván; Ajtay, Zénó; Kiss, István; Németh, Balázs

doi:10.7150/ijms.25687

Cited by 11 publications

(26 citation statements)

References 30 publications

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“…However, the levels of non-specific inflammatory markers (s-ORM and CRP) were significantly higher in patients suffering from severe psoriasis compared to mild psoriatic patients. This indicates that in the case of severe psoriatic patients some grade of systemic inflammation is present 9,45. In our previous study, both u-ORM and u-ORM/u-CREAT ratio were significantly higher in psoriatic patients compared to controls 45.…”

Section: Discussionmentioning

confidence: 75%

“…This indicates that in the case of severe psoriatic patients some grade of systemic inflammation is present 9,45. In our previous study, both u-ORM and u-ORM/u-CREAT ratio were significantly higher in psoriatic patients compared to controls 45. Taking this into account, u-ORM and u-ORM/u-CREAT ratio could be used as an indicator of low-grade inflammation or oxidative stress in mild and moderate psoriasis, as other biomarkers investigated in this study were not able to indicate significant inflammation or excessive oxidative stress in the case of mild and moderate psoriatic patients.…”

Section: Discussionmentioning

confidence: 99%

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<p>Urinary orosomucoid: a new marker of cardiovascular risk in psoriatic patients?</p>

Németh¹,

Péter²,

Boncz³

et al. 2019

TCRM

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Purpose Psoriasis is one of the most common lifelong lasting dermatologic diseases. According to the latest studies, psoriatic patients have a higher risk of developing cardiovascular diseases. Psoriasis is considered as a systemic inflammatory disease. Several oxidative stress markers have been shown to be elevated in psoriasis. However, a panel of biomarkers has not been used yet. This study was aimed at exploring the connection between a panel of biomarkers (C-reactive protein, asymmetric dimethylarginine, uric acid, total antioxidant capacity, malondialdehyde, and orosomucoid [ORM]) and cardiovascular risk in psoriatic patients. Patients and methods The inclusion criterion was the onset of psoriasis with skin lesions. Exclusion criteria were impaired renal function (eGFR<60 mL/min/1.73 m 2 ), acute inflammations (urinary, respiratory, skin inflammation, etc), autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus, or inflammatory bowel disease), and any kind of biological antipsoriatic treatment. Patients with a medical history of myocardial infarction, coronary heart disease, stroke, transient ischemic attack, and carotid artery stenosis were also excluded. Biomarkers were measured by routine procedures, ELISA and HPLC. QRISK®2-2017 was used to assess 10-year risk of cardiovascular disease development. Psoriasis severity was measured by the Psoriasis Area and Severity Index. Results One hundred and fourteen psoriatic patients were enrolled. Only urinary orosomucoid and urinary orosomucoid/urinary creatinine (u-ORM/u-CREAT) ratio showed significant correlation with QRISK score (u-ORM, r=0.245; u-ORM/u-CREAT, r=0.309). When comparing mild psoriatic patients to moderate psoriatic patients, significant differences could only be found in u-ORM and u-ORM/u-CREAT ratio. Conclusion There seems to be a connection between urinary ORM and cardiovascular risk. U-ORM and u-ORM/u-CREAT ratio could be used as an indicator of low-grade inflammation in mild and moderate psoriasis. However, it is the 10-year follow-up of cardiovascular events that will determine the usefulness of this biomarker panel.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

<p>Urinary orosomucoid: a new marker of cardiovascular risk in psoriatic patients?</p>

Németh¹,

Péter²,

Boncz³

et al. 2019

TCRM

Self Cite

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“…Kustán et al [79], in a study conducted in Hungary in patients with psoriasis, measured the levels of water-phase proteins, such as high-specificity reactive C-protein (hsPCR) and orosomucoid in serum and urine (sepsis; ORM and u-ORM). To perform the study, 87 patients were used with levels of mild, moderate, and severe psoriasis and 41 healthy patients as controls.…”

Section: Association Between Some Obesity Biomarkers and Psoriasismentioning

confidence: 99%

Biomarkers of Inflammation in Obesity-Psoriatic Patients

Rodríguez-Cerdeira

Cordeiro-Rodríguez

Carnero-Gregorio

et al. 2019

Mediators of Inflammation

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Psoriasis is a common chronic inflammatory multisystemic disease with a complex pathogenesis consisting of genetic, immunological, and environmental components. It is associated with a number of comorbidities, including diabetes, metabolic syndrome, obesity, and myocardial infarction. In addition, the severity of psoriasis seems to be related to the severity of obesity. Patients with higher levels of obesity show poorer response to systemic treatments of psoriasis. Several studies have demonstrated that white adipose tissue is a crucial site of the formation of proinflammatory adipokines such as leptin, adiponectin, and resistin and classical cytokines such as interleukin- (IL-) 6 and tumour necrosis factor-α. In psoriasis, due to the proliferation of Th1, Th17, and Th22 cells, IL-22, among others, is produced in addition to the abovementioned cytokines. With respect to leptin and resistin, both of these adipokines are present in high levels in obese persons with psoriasis. Further, the plasma levels of leptin and resistin are related to the severity of psoriasis. These results strongly suggest that obesity, through proinflammatory pathways, is a predisposing factor to the development of psoriasis and that obesity aggravates existing psoriasis. Different inflammatory biomarkers link psoriasis and obesity. In this paper, the most important ones are described.

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“…ORM proteins could be applied as diagnostic markers for the early events of many pathological states. Elevated urinary ORM levels have been reported as biomarkers for multiple carcinomas and inflammatory diseases such as psoriasis, Crohn disease, and sepsis (39)(40)(41)(42)(43). Notably, Park et al (44) demonstrated that the urinary levels of ORM1 and ORM2 were increased in patients with RA and correlated with disease activity.…”

Section: Discussionmentioning

confidence: 99%

Urinary Proteomics Identifying Novel Biomarkers for the Diagnosis of Adult-Onset Still’s Disease

et al. 2020

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Adult-onset Still's disease (AOSD) is a systemic, multigenic autoinflammatory disease, and the diagnosis of AOSD must rule out neoplasms, infections, and other autoimmune diseases. Development of a rapid and efficient but non-invasive diagnosis method is urgently needed for improving AOSD therapy. In this study, we first performed a urinary proteomic study using isobaric tags for relative and absolute quantification (iTRAQ) labeling combined with liquid chromatography-tandem mass spectrometry analysis in patients with AOSD and healthy control (HC) subjects. The urinary proteins were enriched in pathways of the innate immune system and neutrophil degranulation, and we identified that the α-1-acid glycoprotein 1 (LRG1), orosomucoid 1 (ORM1), and ORM2 proteins were highly expressed in patients with AOSD. The elevated urine levels of LRG1, ORM1, and ORM2 were further validated by enzyme-linked immunosorbent assay in active patients with AOSD, disease controls, and HC subjects. Receiver operating characteristic curves showed that the areas under the curve of LRG1, ORM1, and ORM2 were 0.700, 0.837, and 0.736, respectively (all p < 0.05). Furthermore, we found that the urine levels of LRG1, ORM1, and ORM2 were positively correlated with the systemic score and erythrocyte sedimentation rate and that the urine levels of LRG1 were positively correlated with interleukin 1β (IL-1β), IL-6, and IL-18 levels, whereas the urine levels of ORM1 were positively correlated with the IL-1β level. Together, our study identified novel urinary markers for non-invasive and simple screening of AOSD.

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Urinary Orosomucoid A Potential Marker Of Inflammation In Psoriasis

Cited by 11 publications

References 30 publications

<p>Urinary orosomucoid: a new marker of cardiovascular risk in psoriatic patients?</p>

<p>Urinary orosomucoid: a new marker of cardiovascular risk in psoriatic patients?</p>

Biomarkers of Inflammation in Obesity-Psoriatic Patients

Urinary Proteomics Identifying Novel Biomarkers for the Diagnosis of Adult-Onset Still’s Disease

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