Serum and urinary markers of skeletal muscle tissue damage after weight lifting exercise

Paul, Gregory L.; DeLany, James P.; Snook, Jean T.; Seifert, Josef; Kirby, Timothy E.

doi:10.1007/bf00637392

Cited by 48 publications

(29 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Perceived soreness was increased above the baseline value following muscle-damaging exercise, with peak values occurring at 48 h. These findings mirror those of previous research, which has demonstrated prolonged increases in muscle soreness peaking between 24 h and 72 h (Newham et al 1983;Jones et al 1987;Newham et al, 1987; Cleak and Eston 1992;Nosaka and Clarkson 1997;Whitehead et al 1998), indicating damage and inflammation of non-contractile connective tissue The changes in CK were consistent with those observed following weightlifting (Paul et al 1989;Byrne and Eston 2002b), plyometric exercise (Horita et al 1999) and downhill running (Eston et al 1996) with values peaking at 48 h after damaging exercise. This is in contrast to the temporal pattern associated with high force eccentric exercise, which demonstrates more of a delayed response peaking at 4 -7 days after exercise Clarkson et al 1992;Byrne et al 2001) Maximal intensity exercise performance…”

Section: Evidence Of Muscle Damagesupporting

confidence: 90%

“…Exercise-induced muscle damage (EIMD) is a common occurrence following activities with a high eccentric component, such as resistance training, plyometrics, distance running and prolonged, intermittent shuttle running (Sherman et al 1984;Paul et al 1989;Chambers et al 1998;Avela et al 1999;Horita et al 1999; Thompson et al 1999;Byrne and Eston 2002a, b;Byrne et al 2004). Of the many symptoms that accompany muscle damage, including soreness, increased blood myofibre proteins, swelling and decreased range of motion, perhaps the most significant factor is the longlasting impairment of muscle function.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

The effects of exercise-induced muscle damage on maximal intensity intermittent exercise performance

2005

View full text Add to dashboard Cite

Exercise-induced muscle damage (EIMD) is a common occurrence following activities with a high eccentric component. Alterations to the torque-velocity relationship following EIMD would appear to have serious implications for athletic performance, particularly as they relate to impairment of maximal intensity exercise. However, this has been studied infrequently. The purpose of this study was to assess the effects of EIMD on maximal intermittent sprint performance. Ten male participants (age 22.4 +/- 3.2 years, height 178.6 +/- 5.2 cm, mass 80.6 +/- 10.7 kg) performed 10 x 6 s cycle ergometer sprints, interspersed with 24 s recovery against a load corresponding to 0.10 kp/kg and 10 x 10 m sprints from a standing start, each with 12 s active (walking) recovery. All variables were measured immediately before and at 30 min, 24, 48 and 72 h following a plyometric exercise protocol comprising of 10 x 10 maximal counter movement jumps. Repeated measures ANOVA showed significant changes over time (all P<0.05) for perceived soreness, plasma creatine kinase activity (CK), peak power output (PPO), sprint time and rate of fatigue. Soreness was significantly higher (P<0.01) than baseline values at all time intervals (3.1, 4.9, 5.5 and 3.2 at 30 min, 24, 48 and 72 h, respectively). CK was significantly elevated (P<0.05) at 24 h (239 IU/l) and 48 h (245 IU/l) compared to baseline (151 IU/l). PPO was significantly lower (P<0.05) than baseline (1,054 W) at all time intervals (888, 946, 852 and 895 W, at 30 min, 24, 48 and 72 h, respectively). The rate of fatigue over the ten cycling sprints was reduced compared to baseline, with the greatest reduction of 48% occurring at 48 h (P<0.01). This was largely attributed to the lower PPO in the initial repetitions, resulting in a lower starting point for the rate of fatigue. Values returned to normal at 72 h. Sprint times over 10 m were higher (P<0.05) at 30 min, 24 h and 48 h compared to baseline (1.96 s) with values corresponding to 2.01, 2.02 and 2.01 at 30 min, 24 h and 48 h, respectively. Values returned to baseline by 72 h. The results provide further evidence that, following a plyometric, muscle-damaging exercise protocol, the ability of the muscle to generate power is reduced for at least 3 days. This is also manifested by a small, but statistically significant reduction in very short-term (approximately 2 s) intermittent sprint running performance. These findings have implications for appropriate training strategies in multiple sprint sports.

show abstract

Section: Evidence Of Muscle Damagesupporting

confidence: 90%

Section: Introductionmentioning

confidence: 97%

The effects of exercise-induced muscle damage on maximal intensity intermittent exercise performance

2005

View full text Add to dashboard Cite

show abstract

“…It is difficult to ascertain whether observed changes in a selected analyte are negatively affected by this change. A study [255] investigating the excretion of the muscle damage marker 3-methylhistidine following resistance exercises showed a decrease in concentration in conjunction with an increase in serum myoglobin and creatine kinase (CK). It is unusual that a change in muscle tissue damage occurs without skeletal muscle protein degradation.…”

Section: Creatininementioning

confidence: 99%

Realising the Potential of Urine and Saliva as Diagnostic Tools in Sport and Exercise Medicine

Lindsay

Costello

2016

Sports Med

View full text Add to dashboard Cite

Accurate monitoring of homeostatic perturbations following various psychophysiological stressors is essential in sports and exercise medicine. Various biomarkers are routinely used as monitoring tools in both clinical and elite sport settings. Blood collection and muscle biopsies, both invasive in nature, are considered the gold standard for the analysis of these biomarkers in exercise science. Exploring non-invasive methods of collecting and analysing biomarkers that are capable of providing accurate information regarding exercise-induced physiological and psychological stress is of obvious practical importance. This review describes the potential benefits, and the limitations, of using saliva and urine to ascertain biomarkers capable of identifying important stressors that are routinely encountered before, during, or after intense or unaccustomed exercise, competition, over-training, and inappropriate recovery. In particular, we focus on urinary and saliva biomarkers that have previously been used to monitor muscle damage, inflammation, cardiovascular stress, oxidative stress, hydration status, and brain distress. Evidence is provided from a range of empirical studies suggesting that urine and saliva are both capable of identifying various stressors. Although additional research regarding the efficacy of using urine and/or saliva to indicate the severity of exercise-induced psychophysiological stress is required, it is likely that these non-invasive biomarkers will represent "the future" in sports and exercise medicine.

show abstract

“…Exercise Induced Muscle Damage (EIMD) is a well-known phenomenon in exercise literature follows unaccustomed eccentric activities [4,5] like plyometric, long distance running and resistance activities [6][7][8][9][10][11][12][13][14]. Eccentric exercise-induced muscle damage is indicated by prolonged decreases in muscle strength range of motion (ROM), swelling, delayed onset muscle soreness (DOMS), increased muscle proteins, CK in the blood [15].…”

mentioning

confidence: 99%

Effect of Chronic Supplementation of Branched Chain Amino Acids on Exercise-Induced Muscle Damage in Trained Athletes

Shenoy¹,

Dhawan²,

Sandhu³

2017

JSS

View full text Add to dashboard Cite

PURPOSE: Branched Chain Amino Acids (BCAA) has been considered an important nutritional strategy to improve skeletal muscle protein turnover in many conditions especially following exercise induced muscle damage. Exercise induced muscle damage (EIMD), a phenomenon impairs muscle function and hampers athletic performance. The effects of consumption of BCAA for a chronic period (4 weeks) on EIMD in trained athletic population have never been explored. Therefore, the aim of the present study was to examine the effects of chronic consumption (4 weeks) of BCAA on indices of muscle damage elicited via a bout of damaging exercise in trained athletes. METHODS: Twenty trained males (20 road cyclists) aged 18-28 years were randomly assigned to two groups (BCAA and Placebo) (n = 10). The damaging exercise consisted of 100 consecutive drop-jumps. Biochemical markers including creatine kinase (CK), high sensitivity c reactive protein (hs-cRP) and myeloperoxidase (MPO), isometric knee muscle strength, muscle soreness, aerobic capacity (VO 2max ) and heart rate (HR) were measured. RESULTS: Differences were observed in pre-and post-supplementation periods among all the participants with mean height and weight values of 168.57 (4.5) cm and 61.74 (4.55) kg respectively as calculated by the anthropologist randomly allocated to the two groups in all tested parameters indicating the effectiveness of BCAA in attenuating muscle damage and enhancing muscle recovery with chronic consumption when compared to placebo, however in contrast to our expectations based on symptoms and our clinical judgment during the study statistically significant difference (P < 0.05) were noticed with biochemical indices only. CONCLUSION: Our findings suggest that chronic BCAA supplementation proved to be an effective meansof reducing muscle damage, enhancing muscle protein synthesis and recovery following EIMD as compared to placebo in well trained athletic population.

show abstract

Serum and urinary markers of skeletal muscle tissue damage after weight lifting exercise

Cited by 48 publications

References 15 publications

The effects of exercise-induced muscle damage on maximal intensity intermittent exercise performance

The effects of exercise-induced muscle damage on maximal intensity intermittent exercise performance

Realising the Potential of Urine and Saliva as Diagnostic Tools in Sport and Exercise Medicine

Effect of Chronic Supplementation of Branched Chain Amino Acids on Exercise-Induced Muscle Damage in Trained Athletes

Contact Info

Product

Resources

About