Effect of Chronic Supplementation of Branched Chain Amino Acids on Exercise-Induced Muscle Damage in Trained Athletes

Abstract

PURPOSE: Branched Chain Amino Acids (BCAA) has been considered an important nutritional strategy to improve skeletal muscle protein turnover in many conditions especially following exercise induced muscle damage. Exercise induced muscle damage (EIMD), a phenomenon impairs muscle function and hampers athletic performance. The effects of consumption of BCAA for a chronic period (4 weeks) on EIMD in trained athletic population have never been explored. Therefore, the aim of the present study was to examine the effects of chronic consumption (4 weeks) of BCAA on indices of muscle damage elicited via a bout of damaging exercise in trained athletes. METHODS: Twenty trained males (20 road cyclists) aged 18-28 years were randomly assigned to two groups (BCAA and Placebo) (n = 10). The damaging exercise consisted of 100 consecutive drop-jumps. Biochemical markers including creatine kinase (CK), high sensitivity c reactive protein (hs-cRP) and myeloperoxidase (MPO), isometric knee muscle strength, muscle soreness, aerobic capacity (VO 2max ) and heart rate (HR) were measured. RESULTS: Differences were observed in pre-and post-supplementation periods among all the participants with mean height and weight values of 168.57 (4.5) cm and 61.74 (4.55) kg respectively as calculated by the anthropologist randomly allocated to the two groups in all tested parameters indicating the effectiveness of BCAA in attenuating muscle damage and enhancing muscle recovery with chronic consumption when compared to placebo, however in contrast to our expectations based on symptoms and our clinical judgment during the study statistically significant difference (P < 0.05) were noticed with biochemical indices only. CONCLUSION: Our findings suggest that chronic BCAA supplementation proved to be an effective meansof reducing muscle damage, enhancing muscle protein synthesis and recovery following EIMD as compared to placebo in well trained athletic population.

Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials

“…The details of study characteristics are summarized in Table 2. The included studies ranged from 2011 to 2018 [33][34][35][36][37][38][39][40][41]. The study design was randomized controlled trial, of which parallel design for 7 studies [33][34][35][36][39][40][41] and crossover design for 2 studies [37,38].…”

“…The included studies ranged from 2011 to 2018 [33][34][35][36][37][38][39][40][41]. The study design was randomized controlled trial, of which parallel design for 7 studies [33][34][35][36][39][40][41] and crossover design for 2 studies [37,38]. Participants from the nine studies were either single [33,[36][37][38] or double blinded [34,35,[39][40][41].…”

“…The study design was randomized controlled trial, of which parallel design for 7 studies [33][34][35][36][39][40][41] and crossover design for 2 studies [37,38]. Participants from the nine studies were either single [33,[36][37][38] or double blinded [34,35,[39][40][41]. The details of study characteristics are summarized in Table 2.…”

“…The total number of participants from all included studies was 278 with age ranging from 21.5 to 24.7 years and mean body mass ranging from 61.7 to 86.4 kg. Participants were declared to be resistance-trained males [37][38][39]41] and specific-sports athletes of soccer and rugby [34,35], wrestling [33,36], and road cycling [40].…”

“…The resistance exercise interventions included multi-joint exercises with barbell [33,[35][36][37][38], back squat [39], drop jump [34,40], and combination of squat and split jump [41]. The intensity of resistance exercise was performed between 70% 1RM to 100% 1RM.…”