Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials

Khemtong, Chutimon; Kuo, Chia‐Hua; Chen, Chih-Yen; Jaime, Salvador J.; Condello, Giancarlo

doi:10.3390/nu13061880

Cited by 18 publications

(29 citation statements)

References 45 publications

(118 reference statements)

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“…Variable results were found as indicators of muscle damage (i.e., creatine kinase and lactate dehydrogenase) at post-exercise across studies. These results were consistent with previous reviews that examined the effects of BCAAs on muscle damage indicators and muscle soreness [ 10 , 18 , 50 ]. Muscle damage markers (creatine kinase, lactate dehydrogenase and myoglobin) were lower at 24 and 48 post-exercise for the BCAA group than the placebo condition.…”

Section: Discussionsupporting

confidence: 93%

“…Electronic databases (Web of Science (all databases), PubMed and Scopus) were searched on 11 February 2022. The search terms were adapted from previous systematic reviews about BCAA supplementation and exercise [ 10 , 11 , 18 ]. A recent narrative review about BCAAs strength and hypotrophy was also considered to define the search terms (6).…”

Section: Methodsmentioning

confidence: 99%

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Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review

et al. 2022

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Branched-chain amino acids (BCAAs) are oxidized in the muscle and result in stimulating anabolic signals—which in return may optimize performance, body composition and recovery. Meanwhile, among athletes, the evidence about BCAA supplementation is not clear. The aim of this study was to review the effects of BCAAs in athletic populations. The research was conducted in three databases: Web of Science (all databases), PubMed and Scopus. The inclusion criteria involved participants classified both as athletes and people who train regularly, and who were orally supplemented with BCAAs. The risk of bias was individually assessed for each study using the revised Cochrane risk of bias tool for randomized trials (RoB 2.0). From the 2298 records found, 24 studies met the inclusion criteria. Although BCAAs tended to activate anabolic signals, the benefits on performance and body composition were negligible. On the other hand, studies that included resistance participants showed that BCAAs attenuated muscle soreness after exercise, while in endurance sports the findings were inconsistent. The protocols of BCAA supplements differed considerably between studies. Moreover, most of the studies did not report the total protein intake across the day and, consequently, the benefits of BCAAs should be interpreted with caution.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review

et al. 2022

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“…The increase in protein synthesis in response to leucine was proposed to be via activating mammalian target of rapamycin (mTOR) [41]. BCAAs supplementation was also found to attenuate muscle damage and ameliorate muscle soreness after resistance exercise in trained men [42].…”

Section: Discussionmentioning

confidence: 99%

The Association of Circulating Amino Acids and Dietary Inflammatory Potential with Muscle Health in Chinese Community-Dwelling Older People

Elshorbagy

Turner

et al. 2022

Nutrients

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Amino acids (AAs) and dietary inflammatory potential play essential roles in muscle health. We examined the associations of dietary inflammatory index (DII) of habitual diet with serum AA profile, and ascertained if the associations between DII and muscle outcomes were mediated by serum AAs using general linear models, in 2994 older Chinese community-dwelling men and women (mean age 72 years) in Hong Kong. Higher serum branched chain AAs (BCAAs), aromatic AAs and total glutathione (tGSH) were generally associated with better muscle status at baseline. A more pro-inflammatory diet, correlating with higher serum total homocysteine and cystathionine, was directly (90.2%) and indirectly (9.8%) through lower tGSH associated with 4-year decline in hand grip strength in men. Higher tGSH was associated with favorable 4-year changes in hand grip strength, gait speed and time needed for 5-time chair stands in men and 4-year change in muscle mass in women. Higher leucine and isoleucine were associated with decreased risk of sarcopenia in men; the associations were abolished after adjustment for BMI. In older men, perturbations in serum sulfur AAs metabolism may be biomarkers of DII related adverse muscle status, while the lower risk of sarcopenia with higher BCAAs may partly be due to preserved BMI.

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“…Adequate consumption of BCAA through supplementation or a BCAA-rich diet has shown positive effects on long-term maintenance of energy balance, body weight regulation, glucose homeostasis, muscle protein synthesis, aging processes, and longevity [55,56]. The ndings of recent meta-analysis studies in clinical trial studies show the positive effects of dietary supplementation of BCAAs on improving liver reserve function in patients with hepatocellular carcinoma and reducing mortality in these patients [57], the positive effects of BCAAs in hepatic encephalopathy [58] and have shown a reduction in muscle damage and pain after resistance training [59].…”

Section: Discussionmentioning

confidence: 99%

Dietary branched chain amino acids relationship with cancer and mortality: A systematic review and meta-analysis

Tabesh

Teymoori

Ahmadirad

et al. 2022

Preprint

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Background Dietary branched chain amino acids (BCAAs) are proposed as a potential related factor in various diseases, including cancer. We aimed to investigate the relationship between dietary intake of BCAAs and their components with cancer and all-cause mortality in a meta-analysis study of observational studies. Methods To identify relevant studies, a comprehensive search was conducted between electronic databases (PubMed, Scopus, and Web of Science) until September 2022. Odds ratios (OR), hazard ratios (HR), and relative risks (RR) with 95% confidence interval (CI) were extracted from eligible studies, and a meta-analysis was performed to calculate the combined effect size. Results Eight articles (3 case-control and 5 cohorts) were included in this meta-analysis. 6 studies reported effect sizes for cancer risk and 3 for cancer or all-cause mortality. Overall, we did not observe any statistically significant association between dietary intake of BCAAs and their components with cancer (RRBCAA: 0.87, 95%CI: 0.68–1.10, RRLeucine: 0.74, 95%CI: 0.52–1.04, RRIsoleucine: 0.98, 95%CI: 0.93–1.04, RRValine: 0.76, 95%CI: 0.55–1.05). Also, we observed any significant relationship between dietary BCAAs and their components with both cancer mortality (RRBCAA: 0.95, 95%CI: 0.68–1.33, RRLeucine: 0.95, 95%CI: 0.79–1.15, RRIsoleucine: 0.95, 95%CI: 0.79–1.14, RRValine: 1.01, 95%CI: 0.84–1.21) and all-cause mortality (RRBCAA: 0.98, 95%CI: 0.73–1.32, RRLeucine: 1.02, 95%CI: 0.81–1.29, RRIsoleucine: 0.96, 95%CI: 0.73–1.27, RRValine: 1.02, 95% CI: 0.79–1.32). Conclusions The findings of the present study showed no significant association between dietary intake of BCAA and its components with cancer, cancer mortality, and all-cause mortality.

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Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials

Cited by 18 publications

References 45 publications

Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review

Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review

The Association of Circulating Amino Acids and Dietary Inflammatory Potential with Muscle Health in Chinese Community-Dwelling Older People

Dietary branched chain amino acids relationship with cancer and mortality: A systematic review and meta-analysis

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