Serum and Salivary Matrix Metalloproteinases, Neutrophil Elastase, Myeloperoxidase in Patients with Chronic or Aggressive Periodontitis

Nizam, Nejat; Gümüş, Pınar; Pitkänen, Jari; Tervahartiala, Taina; Sorsa, Timo; Buduneli, Nurcan

doi:10.1007/s10753-014-9907-0

Cited by 49 publications

(48 citation statements)

References 35 publications

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“…The current results are in line with reported increased levels of MMP‐8 in saliva from patients with periodontitis, 30,37 as well as in GCF from children with AgP 38 . On the other hand, Nizam et al 39 did not find significant differences in MMP‐8 levels in serum or saliva between patients with AgP and healthy patients, which could be at least partially related to the higher age in healthy patients. Also, the former study used an immunofluorometric assay, which may differ in the sensitivity and ability to detect active forms of MMP‐8 40 compared with the current analysis, which could also account for the contradictory results.…”

Section: Discussionsupporting

confidence: 91%

Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis

Lira-Júnior

Öztürk

Emingil

et al. 2017

Journal of Periodontology

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Section: Discussionsupporting

confidence: 91%

Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis

Lira-Júnior

Öztürk

Emingil

et al. 2017

Journal of Periodontology

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“…Myeloperoxidase has been shown to be elevated in inflammatory periodontal sites [32]. It was suggested that MPO could be regarded as an indicator of increased risk for local and systemic inflammation such as periodontal tissue destruction or as an early sign of atherosclerosis [33]. The present results showed that statins might have a local antioxidant efficacy demonstrated with low levels of MPO.…”

Section: Discussionsupporting

confidence: 52%

Statins and IL-1β, IL-10, and MPO Levels in Gingival Crevicular Fluid: Preliminary Results

et al. 2016

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Statins possess a wide variety of pleiotropic properties that are independent of their lipid-lowering abilities such as attenuating inflammation, oxidative stress, coagulation, platelet aggregation and stimulating bone formation. The aim of the study is to evaluate the effect of statins on clinical periodontal parameters and gingival crevicular fluid (GCF) levels of IL-1β, IL-10, and myeloperoxidase (MPO) in inflammatory periodontal diseases. Seventy-nine subjects with hyperlipidemia and 48 systemically healthy controls (C) were included. Hyperlipidemic patients were either given a diet (HD) or prescribed statin (HS). Patients were classified into three subgroups as those who were periodontally healthy (h), who had gingivitis (g), or who had chronic periodontitis (p). Blood samples were collected for the measurement of lipid profiles. Plaque index (PI), gingival index (GI), probing pocket depth (PD), clinical attachment level (CAL), and percentage of bleeding on probing (BOP) were recorded. Gingival crevicular fluid levels of IL-1β, IL-10, and MPO were measured in order to determine the anti-inflammatory and antioxidant effects of statins. Probing depth values of the HSp group were significantly lower than those of the Cp group. Percentage of BOP of the HSg group was significantly lower than those of the HDg and Cg groups. While the IL-1β level of the HSp group was significantly lower than that of the HDp group, IL-10 levels of the HSg group were significantly higher than those of the HDg group. MPO levels were significantly lower in the HSg group when compared to those in the HDg and Cg groups. Statin use decreased the IL-1β and MPO levels and enhanced IL-10 in GCF. It can be suggested that statins may attenuate periodontal inflammation and progression of periodontal inflammation.

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“…9 MMPs and TIMPs are also produced locally in periodontium and altered levels of MMPs are associated with inflammation related with gingivitis and periodontitis. 10,11 MMP-8 is a proteolytic enzyme secreted mainly by neutrophils that is present in inflamed gingiva, gingival crevicular fluid (GCF), saliva and serum. MMP-8 can be activated both by host and bacterial enzymes.…”

Section: Introductionmentioning

confidence: 99%

Elevated matrix metalloproteinase-8 in saliva and serum in polycystic ovary syndrome and association with gingival inflammation

et al. 2015

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This study aimed to investigate the levels of matrix metalloproteinase-8 (MMP-8) and tissue inhibitors of MMP-1 (TIMP-1) in saliva and serum samples of women with polycystic ovary syndrome (PCOS; n = 80) and matched systemically healthy controls (n = 45), with varying degrees of gingival inflammation. Salivary levels of MMP-8 and the MMP-8/TIMP-1 ratio were significantly elevated in women with PCOS, who also exhibited more gingivitis than systemically healthy women. No major changes were observed in salivary TIMP-1 levels with regard to PCOS. Serum levels of MMP-8 and the MMP-8/TIMP-1 ratio were significantly higher in women with PCOS, irrespective of the presence of gingivitis, while there were no differences in TIMP-1 levels. A positive correlation was indicated between probing depth, bleeding on probing, plaque index and salivary or serum MMP-8 levels or MMP-8/TIMP-1 ratio in the case of PCOS, while a negative such correlation was revealed for TIMP-1 in systemically healthy women. Increased levels of MMP-8 in saliva and serum seem to be more pronounced in women with PCOS, and potentiated in the presence of gingival inflammation. Alterations in MMP/TIMP system triggered by local and systemic inflammation may be implicated in the pathogenesis of PCOS, or the deterioration of its clinical presentation.

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Serum and Salivary Matrix Metalloproteinases, Neutrophil Elastase, Myeloperoxidase in Patients with Chronic or Aggressive Periodontitis

Cited by 49 publications

References 35 publications

Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis

Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis

Statins and IL-1β, IL-10, and MPO Levels in Gingival Crevicular Fluid: Preliminary Results

Elevated matrix metalloproteinase-8 in saliva and serum in polycystic ovary syndrome and association with gingival inflammation

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