Serum and ovarian Müllerian inhibiting substance, and their decline in reproductive aging

Yeh, John; Kim, Beomsu; Peresie, Jennifer; Liang, Yuan; Arroyo, Amanda

doi:10.1016/j.fertnstert.2006.11.011

Cited by 16 publications

(9 citation statements)

References 39 publications

(51 reference statements)

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“…As with ovarian exhaustion in women (van Disseldorp et al 2008), other primates (Appt et al 2010) and rodent species (Kevenaar et al 2006, Yeh et al 2007, AMH concentrations were shown to decline with age in mares and to correlate positively with antral follicle count (AFC), especially in aging mares over 19 years of age (Claes et al 2015). To date however, few studies have evaluated in a quantitative way how accurately experimentally induced changes in ovarian reserve are predicted by AMH, in part because of the difficulty in counting or estimating total follicle population numbers (Hansen & Soules 2008).…”

Section: Introductionmentioning

confidence: 99%

Anti-Müllerian hormone and ovarian aging in mares

Uliani

Conley

Corbin

et al. 2019

Journal of Endocrinology

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Anti-Müllerian hormone (AMH) is used as a marker of follicle population numbers and potential fertility in several species including horses but limited data exist across the lifespan. No one has decreased ovarian reserve experimentally to investigate whether a corresponding, quantitative decrease in AMH results. Concentrations of AMH across the lifespan were compiled from 1101 equine females sampled from birth to >33 years of age. Young and old mares (averaging 6 and 19 years) were hemi-ovariectomized and circulating AMH was assessed before and daily thereafter for 15 days. The remaining ovary was removed later and blood was drawn again before and after this second surgery for AMH determination. Polynomial regression analysis and analysis of mares grouped by 5-year intervals of age demonstrated AMH concentrations to be higher in mares aged 5–10 and 10–15 years than 0–5 years of age and lower in mares after 20 years of age. There was high variability in AMH concentrations among neonatal fillies, some of which had concentrations typical of males. Hemi-ovariectomy was followed by a decrease of AMH, almost exactly halving concentrations in intact mares. Concentrations of AMH had returned to intact levels in old mares before complete ovariectomy, as if exhibiting ovarian compensatory hypertrophy, but recovery of AMH was not evident in young mares. AMH may reflect ovarian senescence in mares after 20 years of age but is too variable to do so in the first two decades of life. The ovarian endocrine response to hemi-ovariectomy in mares appears to change with age.

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Section: Introductionmentioning

confidence: 99%

Anti-Müllerian hormone and ovarian aging in mares

Uliani

Conley

Corbin

et al. 2019

Journal of Endocrinology

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“…This indicates that the exhaustion of ovarian follicles is not a limiting factor in rodent reproductive aging. Because of these differences in ovarian morphology markers of ovarian reserve in women such as AMH which shows an age-dependent decline (64) are not applicable in rodents (65). This is supported by our data showing no differences in AMH levels in aging LBW offspring compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Maternal undernutrition induces premature reproductive senescence in adult female rat offspring

Khorram

Keen-Rinehart

Chuang

et al. 2015

Fertility and Sterility

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Objective To determine the effects of maternal undernutrition (MUN) on the reproductive axis of aging offspring. Design Animal (rat) study. Setting Research Laboratory. Animals Female Sprague-Dawley rats. Intervention(s) Food restriction during the second half of pregnancy in rats. Main Outcome Measures Circulating gonadotropins, Anti-Mullerian Hormone (AMH), ovarian morphology, estrous cyclicity and gene expression studies in the hypothalamus and ovary in 1 day old (P1) and aging adult offspring. Results Offspring of MUN dams had low birth weight (LBW) and by adult age developed obesity. 80% of adult LBW offspring had disruption of estrous cycle by 8 months of age with the majority of animals in persistent estrous. Ovarian morphology was consistent with acyclicity with ovaries exhibiting large cystic structures and reduced corpora lutea. There was an elevation in circulating testosterone (T), increased ovarian expression of enzymes involved in androgen synthesis, an increase in plasma Leuteinizing (LH/)/Follicle Stimulating hormone (FSH) levels, reduced estradiol (E2) levels and no changes in AMH in adult LBW offspring compared to control offspring. Hypothalamic expression of leptin receptor (OBRb), estrogen receptor-α (ER-α) and Gonadotropin Releasing hormone (GnRH) protein were altered in an age-dependent manner with increased ObRb, ER-α expression in P1 LBW hypothalami and a reversal of this expression pattern in adult LBW hypothalami. Conclusion Our data indicates that the maternal nutritional environment programs reproductive potential of the offspring through alteration of the hypothalamic-pituitary-gonadal axis. The premature reproductive senescence in LBW offspring could be secondary to development of obesity and hyperleptinemia in these animals in adult life.

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“…The reproductive aging animals are useful for delineating changes in m€ ullerian-inhibiting substance (MIS) and other hormonal changes (30)(31)(32). The animals were maintained under standard housing conditions with a 12:12 hour light cycle and were given access to standard rat chow (Harlan) and water ad libitum.…”

Section: Materials and Methods Animals And Treatmentmentioning

confidence: 99%