Ovarian vascular endothelial growth factor and vascular endothelial growth factor receptor patterns in reproductive aging

Abnormal DNA methylation in oocytes could be associated with a decrease in reproductive potential in old mice

“…It is reported that maternal factors, including neuroendocrine inadequacy [7,8], uterine apparatus failure [9,10], and such fetal factors as spotty oocytes or subsequent embryos [11,12], have been correlated with female reproductive aging. In addition, an increase in the incidence of aneuploidy is well documented with increasing maternal age, particularly in humans [13,14].…”

Changes in acetylation on lysine 12 of histone H4 (acH4K12) of murine oocytes during maternal aging may affect fertilization and subsequent embryo development

“…Maternal factors such as neuroendocrine inadequacy (4,5) and uterine apparatus failure, (6,7), and fetal factors such as spotty oocytes or subsequent embryos (8,9), have been correlated with female reproductive aging. Some studies, however, have indicated that when embryos produced from women <35 years of age were transferred into the uteri of women up to 59 years old, the establishment of pregnancy was not affected by age of the recipient (10,11).…”

The Impact of Aging on Fertility: Similarities and Differences between Ovaries and Testes

“…These modifications affect the ovarian microenvironment during folliculogenesis, influencing the developmental capacity of the oocytes. It was also suggested that AGEs produce perturbation in perifollicular vascularization by a complex relationship with vascular endothelial growth factor (VEGF) [102,103]. Therefore, the maturation, chromosomal constitution of the oocytes, and granulosa cell metabolism are modified.…”