Serum and liver lipids in rats and chicks fed with diets containing different oils

Feóli, Ana Maria Pandolfo; Roehrig, Cíntia; Rotta, Liane Nanci; Krüger, Adriane Huth; Souza, Karine Bresolin de; Kessler, Alexandre de Mello; Renz, Sandro V; Brusque, Ana Maria; Souza, Daiana de; Perry, Marcos L. S.

doi:10.1016/s0899-9007(03)00106-0

Cited by 33 publications

(28 citation statements)

References 23 publications

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“…The rise in cholesterol in liver and plasma may be due to increased uptake of exogenous cholesterol and subsequent deposition and decreased cholesterol catabolism as evidenced by a reduction in bile acid production and turnover of bile acids. The metabolism of free and ester cholesterol are impaired in the liver, spleen and thymus tissue and the rate of turnover was specifically decreased in all tissues of hyperlipidemic rats (Feoli et al, 2003).…”

Section: Discussionmentioning

confidence: 92%

“…A high fat diet produces an increase in TAG levels due to lipoprotein lipase TAG hydrolysis, so that the accumulation in the liver becomes more evident (Feoli et al, 2003). In contrast, the effect of PUFA can be attributed to a reduction in the hepatic synthesis of fatty acid, which decreases the Figure 1A show the levels of serum TAG of hyperlipidemic rats fed fruit pomace.…”

Section: Triacylglycerols (Tag) and Total Cholesterol (Tc)mentioning

confidence: 99%

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<i>Physalis peruviana</i> pomace suppresses highcholesterol diet-induced hypercholesterolemia in rats

Ramadan

2012

Grasas y Aceites

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Physalis peruviana (goldenberry) is a promising fruits that can be an ingredient in several functional foods. No reports are available on the effect of the administration of goldenberry pomace on different aspects of the plasma lipid profile in experimental animals. According to the chemical composition of the fruit pomace which includes high levels of bioactive compounds, the hypothesis was that feeding Physalis peruviana pomace may have health-promoting and hypercholesterolemic impacts on rats fed a high cholesterol diet (HCD). Therefore, the objective of this study was to investigate the effect of feeding goldenberry pomace on hypercholesterolemia by analyzing the changes in lipid profiles in HCD fed rats. The chemical composition, lipid profiles (fatty acids, tocopherols and sterols) and phenolic contents of the fruit pomace were determined. Generally, rats fed the fruit pomace showed lower levels of total cholesterol (TC), total triacylglycerol (TAG) and total low density lipoprotein (LDL) cholesterol as well as higher levels of high density lipoprotein (HDL) cholesterol in comparison with animals fed HCD and cholesterol free diets (CFD). Histological examinations of the liver and kidney were also studied. The results demonstrated that goldenberry pomace consumption provides overall beneficial effects on reversing HCD associated detrimental changes.

Physalis peruviana (aguaymanto) es un fruto prometedor que puede ser parte de diferentes alimentos funcionales. No hay datos disponibles sobre el efecto de la administración del orujo de aguaymanto sobre diferentes aspectos del perfil de lipídos plasmáticos en animales de experimentación. De acuerdo con la composición química del orujo de la fruta que incluye altos niveles de compuestos bioactivos, se demostró la hipótesis de que la alimentación con orujo de Physalis peruviana puede tener efectos saludables y sobre la hipercolesterolemia en ratas alimentadas con una dieta alta en colesterol (HCD). Por tanto, el objetivo de este estudio fue investigar el efecto de una alimentación con orujo de Physalis peruviana o sobre la hipercolesterolemia analizando los cambios del perfil lipídico en ratas alimentadas con una dieta alta en colesterol (HCD). Se determinó la composición química, el perfil lipídico (ácidos grasos, tocoferoles y esteroles) y contenido fenólico del orujo de aguaymanto. En términos generales, las ratas alimentadas con orujo de aguaymanto mostraron niveles más bajos de colesterol total (TC), triglicéridos totales (TAG) y lipoproteínas de baja densidad totales, así como superiores niveles de lipoproteínas de alta densidad (HDL) en comparación con los animales alimentados con HCD y con una dieta libre de colesterol (CFD). El examen histológico del hígado y de los riñones fue también realizado. Los resultados demostraron que el consumo de orujo de aguaymanto proporciona efectos beneficiosos generales invirtiendo los cambios perjudiciales asociados a una dieta HCD

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Section: Discussionmentioning

confidence: 92%

Section: Triacylglycerols (Tag) and Total Cholesterol (Tc)mentioning

confidence: 99%

<i>Physalis peruviana</i> pomace suppresses highcholesterol diet-induced hypercholesterolemia in rats

Ramadan

2012

Grasas y Aceites

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“…Most experiments in animals to elucidate the effect of dietary fat on serum lipids supplemented their diet with cholesterol, including studies showing that cholesterol supplemented coconut oil raises serum cholesterol compared to most other dietary fats, such as olive oil, rapeseed oil, sunflower oil or soybean oil 4,19) . Another study has shown that coconut oil raises serum cholesterol and reduces HDL-cholesterol compared to olive oil, corn oil and avocado oil in rabbits 20) .…”

Section: Discussionmentioning

confidence: 99%

“…Most previous experiments conducted in animals to study the effect of dietary fats on serum cholesterol and atheroma formation have supplemented the diet with cholesterol, and the results obtained are not uniform [4][5][6][7] . Various investigators have studied the effect of different dietary fats on lipid peroxidation in animals 8,9) , though their effect on antioxidant parameters has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Effect of High Fat Diet Without Cholesterol Supplementation on Oxidative Stress and Lipid Peroxidation in New Zealand White Rabbits

Sabitha

Vasudevan

Kamath

2010

JAT

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Aim: Dietary fats may affect coronary artery disease risk by influencing factors other than serum cholesterol. The effect of diets containing coconut oil and sunflower oil without cholesterol supplementation on oxidative stress and lipid peroxidation was studied in male New Zealand White rabbits. Methods: Animals assigned to four groups (control, cholesterol-fed, coconut oil-fed and sunflower oil-fed), given an isocaloric diet and studied for 6 months. The lipid profile, reduced glutathione, glutathione peroxidase, superoxide dismutase, vitamin C and lipid peroxidation were evaluated at the beginning of the study, at the third month and at the end of the study period. Results: Serum lipid values did not show significant variation between animals fed coconut oil and sunflower oil, but total cholesterol, triglycerides and LDL-cholesterol were significantly higher and HDL-cholesterol was reduced in cholesterol-fed animals. Lipid peroxidation was higher in cholesterol-fed and sunflower oil-fed rabbits compared to controls and coconut oil-fed rabbits. Though other parameters such as reduced glutathione, glutathione peroxidase, superoxide dismutase and ascorbate did not vary between the two oil-fed rabbit groups, cholesterol-fed rabbits showed severe oxidative stress. Conclusion: We conclude that in the absence of cholesterol supplementation, coconut oil intake up to 30% of daily energy supply did not cause hypercholesterolemia or oxidative stress in rabbits.J Atheroscler Thromb, 2010; 17:213-218.

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“…The control diet contained 12% soybean oil (unsaturated fatty acids), and in exchange for the soybean oil, the experimental diet contained 2% cholesterol and 10% hydrogenated coconut oil, as used in previous studies (Table 1 [20,52]). …”

Section: Dietary Compositionmentioning

confidence: 99%

Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat

Granholm

Bimonte‐Nelson

Moore

et al. 2008

JAD

240

198

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Diets rich in cholesterol and/or saturated fats have been shown to be detrimental to cognitive performance. Therefore, we fed a cholesterol (2%) and saturated fat (hydrogenated coconut oil, Sat Fat 10%) diet to 16-month old rats for 8 weeks to explore the effects on the working memory performance of middle-aged rats. Lipid profiles revealed elevated plasma triglycerides, total cholesterol, HDL, and LDL for the Sat-Fat group as compared to an iso-caloric control diet (12% soybean oil). Weight gain and food consumption were similar in both groups. Sat-Fat treated rats committed more working memory errors in the water radial arm maze, especially at higher memory loads. Cholesterol, amyloid-β peptide of 40 (Aβ40) or 42 (Aβ42) residues, and nerve growth factor in cortical regions was unaffected, but hippocampal Map-2 staining was reduced in rats fed a SatFat diet, indicating a loss of dendritic integrity. Map-2 reduction correlated with memory errors. Microglial activation, indicating inflammation and/or gliosis, was also observed in the hippocampus of Sat-Fat fed rats. These data suggest that saturated fat, hydrogenated fat and cholesterol can profoundly impair memory and hippocampal morphology.

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Serum and liver lipids in rats and chicks fed with diets containing different oils

Cited by 33 publications

References 23 publications

<i>Physalis peruviana</i> pomace suppresses highcholesterol diet-induced hypercholesterolemia in rats

<i>Physalis peruviana</i> pomace suppresses highcholesterol diet-induced hypercholesterolemia in rats

Effect of High Fat Diet Without Cholesterol Supplementation on Oxidative Stress and Lipid Peroxidation in New Zealand White Rabbits

Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat

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