Serum and Corpuscular Nickel and Zinc in Chronic Hemodialysis Patients

Hosokawa, Shinichi; Nishitani, Hiroshi; Umemura, Kisaburo; Tomoyoshi, T; Sawanishi, K; Yoshida, Osamu

doi:10.1159/000184098

Cited by 20 publications

(10 citation statements)

References 2 publications

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“…Indeed, several investigators [7,8,21,22] reported that high Al and Si levels cause bone diseases in chronic HD patients. Zn, Mn and Ni are essential trace elements for human nutrition [9,1116,[18][19][20]. In general, serum Zn.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, we and others reported that abnormalities of aluminum [1][2][3][4], silicon [5][6][7][8], zinc [9][10][11][12], manganese [13][14][15][16] and nickel [17][18][19][20] caused various kinds of compli cations in chronic hemodialysis (HD) patients. Elevated serum Al levels in chronic HD patients [1][2][3][4] were asso ciated with encephalopathy [3].…”

Section: Introductionmentioning

confidence: 99%

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Trace Elements and Complications in Patients Undergoing Chronic Hemodialysis

Hosokawa

Oyamaguchi

Yoshida

1990

Nephron

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Abnormalities of trace elements such as aluminum, silicon, zinc, manganese and nickel were found in chronic hemodialysis (HD) patients. The relationship between serum concentration of trace elements and complications such as anemia bone disease, neurological disorder and nutritional disorder in 100 chronic HD patients was examined. Serum Al and Si levels were very high in these patients, and were negatively correlated with indicators of anemia such as RBC, hemoglobin and hematocrit values. Serum Al and Si levels in the HD patients with peripheral neurological disorder (excluding encephalopathy) and with bone disease were significantly high. The levels of serum Zn, Mn and Ni were low, and were correlated with total serum protein levels. In summary, in order to prevent some complications in chronic HD patients, it is very important to regulate levels of trace elements.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Trace Elements and Complications in Patients Undergoing Chronic Hemodialysis

Hosokawa

Oyamaguchi

Yoshida

1990

Nephron

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“…Conversely, other papers reported normal [20] or low nickel levels in serum of HD patients [22,23]. Dialysis fluid may be a source of increased serum nickel [36] which may then accumulate in bone and tissues of ESRD patients [97].…”

Section: Nickelmentioning

confidence: 94%

“…The erythrocyte Zn concentration in patients with chronic renal failure (CRF) was reported to be low [8], normal (3 papers) [17], but more often increased [18,19,22,29]. High erythrocyte Zn in the presence of low plasma Zn in patients with renal failure is probably in relation to the activity of the major Zn-containing erythrocyte enzyme carbonic anhydrase.…”

Section: Zincmentioning

confidence: 99%

Trace Elements in End-Stage Renal Disease

Zima¹,

Tesař²,

Mestek

et al. 1999

Blood Purif

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For human beings trace elements are essential nutrients with a gamut of functions. They are for instance indispensable components of many enzymes, so they have some regulatory functions and they may affect immune reactions and free radical generation. Abnormalities of trace elements are primarily the result of uremia, and they may be further modified and sometimes greatly exacerbated by the dialysis procedure. The role of trace elements in hemodialysis (HD) patients has not yet been fully characterized. To prevent some complications in chronic HD patients, it is very important to regulate the levels of trace elements by adequate water treatment. Reverse osmosis is able to prevent the accumulation of the majority of trace elements in the patients. Zinc supplementation may be recommended for patients with proven zinc deficiency, but for all chronic renal failure patients it is questionable. Selenium deficiency is to be suspected in dialyzed patients and selenium supplementation may be beneficial (increasing glutathione peroxidase activity, cardioprotective effect, immunostimulatory properties) for chronic renal failure patients. Supplementation with a trace element may be indicated when its depletion was unequivocally documented and when there is evidence of the positive effects of this element on the quality of life of the dialyzed patients.

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“…The zinc metabolism is altered in chronic uremia, and it is not corrected by maintenance dialysis therapy [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16]. Zinc supplementation has been shown to improve some abnormalities in uremic patients [8, 9, 10, 17].…”

Section: Introductionmentioning

confidence: 99%

Possible Site of Decreased Intestinal Zinc Absorption in Chronic Uremic Rats

Wang¹,

Chen²,

Chen

et al. 2001

Nephron

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Background/Aims: Previous zinc tolerance tests in uremic patients indicated decreased intestinal zinc absorption. In the present study, a zinc tolerance test was initially applied to a uremic rat model and subsequently the possible site of malabsorption investigated. Methods: Chronic uremia was induced by five-sixths nephrectomy. Both control and nephrectomized rats were divided into three groups including animals with intact intestine, removal of the jejunum, and removal of the ileum. Each rat was orally loaded with zinc sulfate (80 mg/kg) in conscious state. Blood samples were drawn before and after zinc load at different intervals during 6 h for zinc analysis. The area under the plasma zinc curve (AUC) and the maximal increase of plasma zinc level (C_max) were calculated. Results: Jejunectomy decreased both AUC and C_max in control and nephrectomized rats, whereas ileectomized animals remained, interestingly, unchanged with regard to these two parameters. Significant decreases in both AUC and C_max were observed in nephrectomized rats as compared with the control rats. Conclusions: The jejunum is the main site of zinc absorption in response to a large oral load of zinc sulfate in both normal and uremic rats. The data further suggest that five-sixths nephrectomy reduces gastrointestinal zinc absorption in rats predominantly by the ileum.

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Serum and Corpuscular Nickel and Zinc in Chronic Hemodialysis Patients

Cited by 20 publications

References 2 publications

Trace Elements and Complications in Patients Undergoing Chronic Hemodialysis

Trace Elements and Complications in Patients Undergoing Chronic Hemodialysis

Trace Elements in End-Stage Renal Disease

Possible Site of Decreased Intestinal Zinc Absorption in Chronic Uremic Rats

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