Trace Elements and Complications in Patients Undergoing Chronic Hemodialysis

Hosokawa, Shinichi; Oyamaguchi, A; Yoshida, Osamu

doi:10.1159/000186003

Cited by 54 publications

(26 citation statements)

References 14 publications

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“…[8][9][10][11][12][13][14][15][16][17][18][19][20][21] In patients undergoing hemodialysis, serum manganese concentration is reported to be low, compared with that in the healthy population, 32 and the reason is thought to be removal of manganese from blood during hemodialysis. It, thus, theoretically is reasonable that manganese intoxication would be unlikely in patients undergoing hemodialysis if the dialysate is not severely contaminated by manganese.…”

Section: Discussionmentioning

confidence: 99%

A Preliminary Study Revealing a New Association in Patients Undergoing Maintenance Hemodialysis: Manganism Symptoms and T1 Hyperintense Changes in the Basal Ganglia

Silva¹,

Rocha²,

Jeronymo³

et al. 2007

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE:Patients undergoing parenteral nutrition and those with portosystemic encephalopathy secondary to chronic liver disease and acquired and congenital portosystemic venous shunts frequently present manganese deposition in the basal ganglia, detected by MR imaging as hyperintense areas on T1-weighted sequences. We also observed similar abnormalities in the basal ganglia of patients with chronic renal failure undergoing maintenance hemodialysis. Our aim was to evaluate the pallidal signal intensity on T1-weighted images in a series of patients undergoing hemodialysis, with further evaluation of serum manganese levels and neurologic correlation, comparing them with patients with chronic renal failure without dialytic treatment.

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Section: Discussionmentioning

confidence: 99%

A Preliminary Study Revealing a New Association in Patients Undergoing Maintenance Hemodialysis: Manganism Symptoms and T1 Hyperintense Changes in the Basal Ganglia

Silva¹,

Rocha²,

Jeronymo³

et al. 2007

American Journal of Neuroradiology

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“…Serum manganese levels were reported to decrease in parallel with the decrease in creatinine clearance [96] and total serum protein levels [23]. On the other hand, manganese plasma levels were shown to be normal [8,[18][19][20][21] or even increased in uremic patients [8].…”

Section: Manganesementioning

confidence: 99%

Trace Elements in End-Stage Renal Disease

Zima¹,

Tesař²,

Mestek

et al. 1999

Blood Purif

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For human beings trace elements are essential nutrients with a gamut of functions. They are for instance indispensable components of many enzymes, so they have some regulatory functions and they may affect immune reactions and free radical generation. Abnormalities of trace elements are primarily the result of uremia, and they may be further modified and sometimes greatly exacerbated by the dialysis procedure. The role of trace elements in hemodialysis (HD) patients has not yet been fully characterized. To prevent some complications in chronic HD patients, it is very important to regulate the levels of trace elements by adequate water treatment. Reverse osmosis is able to prevent the accumulation of the majority of trace elements in the patients. Zinc supplementation may be recommended for patients with proven zinc deficiency, but for all chronic renal failure patients it is questionable. Selenium deficiency is to be suspected in dialyzed patients and selenium supplementation may be beneficial (increasing glutathione peroxidase activity, cardioprotective effect, immunostimulatory properties) for chronic renal failure patients. Supplementation with a trace element may be indicated when its depletion was unequivocally documented and when there is evidence of the positive effects of this element on the quality of life of the dialyzed patients.

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“…The results are listed in Table 3. The estimated blood silicon concentrations of healthy subjects published by other researchers were in the range of 3 to 25 µmol l -1 for serum, [9][10][11][12]19,20 and less than 180 µmol l -1 for whole blood. 17,18,20 Especially for whole blood, the number of publications is not very many, and the reported values have thus been uncertain among researchers.…”

Section: Determination Of Silicon In Serum Whole Blood and Erythrocmentioning

confidence: 97%

“…Graphite furnace atomic absorption spectroscopy (GF-AAS), [9][10][11][12][13][14][15][16][17][18] inductively coupled plasma atomic emission spectroscopy (ICP-AES), 19 direct current plasma atomic emission spectroscopy (DCP-AES) 20 and spectrophotometry 21 have been used for the determination of silicon in blood samples. However, the determination of a small amount of silicon in blood is often interfered due to the complicated composition of organic and inorganic matrices.…”

Section: Introductionmentioning

confidence: 99%

An Indirect Spectrophotometric Method for the Determination of Silicon in Serum, Whole Blood and Erythrocytes

Tamada

2003

ANAL. SCI.

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An indirect method for the determination of silicon in blood samples has been developed. The proposed method overcame interference from a large amount of salts and phosphate in blood samples, and enabled us to determine the silicon contents in serum and whole blood by the same operation. After blood samples were digested by microwave heating, silicon, present as silicate in the sample solution, was reacted with molybdate to form a silicomolybdate complex. The complex was then separated from unreacted molybdate by a cation-exchange resin column. The molybdate liberated from the complex was spectrophotometrically determined in place of silicon. Since the method is not affected the composition of matrices between serum and whole blood, it could achieve good precision and accuracy, and could also estimate the silicon contents in erythrocytes from those in serum and whole blood. The sensitivity of the method was almost equal to that of the conventional silicomolybdenum blue method, and the calibration curve was linear up to 50 µmol l -1 of silicon with a detection limit of 1.1 µmol l -1 in whole blood. The mean concentrations of silicon in five healthy subjects were 11 µmol l -1 for serum, 28 µmol l -1 for whole blood and 50 µmol l -1 for erythrocytes. Thus, the obtained distribution ratio between serum and erythrocytes was in the range of 0.15 -0.39, and was found to be included in a narrow range.

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Trace Elements and Complications in Patients Undergoing Chronic Hemodialysis

Cited by 54 publications

References 14 publications

A Preliminary Study Revealing a New Association in Patients Undergoing Maintenance Hemodialysis: Manganism Symptoms and T1 Hyperintense Changes in the Basal Ganglia

A Preliminary Study Revealing a New Association in Patients Undergoing Maintenance Hemodialysis: Manganism Symptoms and T1 Hyperintense Changes in the Basal Ganglia

Trace Elements in End-Stage Renal Disease

An Indirect Spectrophotometric Method for the Determination of Silicon in Serum, Whole Blood and Erythrocytes

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