Serum amyloid P-component/C-reactive proteins in fugu (Takifugu rubripes) egg with binding ability to disease-causing bacteria by carbohydrate-recognition

SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis

“…Periodontitis is mainly caused by oral microbiome dysbiosis and host immune responses [2] . SAP is a pattern recognition molecule that modulates bacterial infections and inflammation in various diseases [33] , [34] , [35] . However, the level of SAP in periodontal tissue and its role in periodontitis pathogenicity is still unknown.…”

“…SAP regulates bacterial virulence and host immune cells function differentially in a bacteria and disease-specific manner [34] , [52] . In this study, SAP-KO altered the oral microbiome of periodontitis mice with the most significant abundance of Porphyromonas at the genus level and the lower abundance of the overall oral microbiome.…”