Serum adropin levels are decreased in patients with acute myocardial infarction

Yu, Honggang; Zhao, Peng; Wu, Mingchun; Liu, Jian; Yin, Wen

doi:10.1016/j.regpep.2014.04.001

Cited by 82 publications

(71 citation statements)

References 16 publications

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“…Recent clinical studies reported a fall in circulating adropin level in patients with cardiovascular diseases, such as coronary artery disease, cardiac syndrome X, and stable angina pectoris, relative to healthy control adults (8,33,34). Furthermore, in patients with type 2 diabetes mellitus (30) and children with obstructive sleep apnea (13), low circulating adropin levels are associated with endothelial dysfunction, as assessed by using brachial flow-mediated dilatation (FMD) and forearm reactive hyperemia after cuff-induced occlusion.…”

Section: Discussionmentioning

confidence: 99%

Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults

Fujie

Hasegawa

Sato

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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Fujie S, Hasegawa N, Sato K, Fujita S, Sanada K, Hamaoka T, Iemitsu M. Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults. Am J Physiol Heart Circ Physiol 309: H1642-H1647, 2015. First published September 14, 2015; doi:10.1152/ajpheart.00338.2015.-Aging-induced arterial stiffening is reduced by aerobic exercise training, and elevated production of nitric oxide (NO) participates in this effect. Adropin is a regulator of endothelial NO synthase and NO release, and circulating adropin level decreases with age. However, the effect of habitual aerobic exercise on circulating adropin levels in healthy middleaged and older adults remains unclear. We sought to determine whether serum adropin level is associated with exercise training-induced changes in arterial stiffness. First, in a cross-sectional study, we investigated the association between serum adropin level and both arterial stiffness and cardiorespiratory fitness in 80 healthy middle-aged and older subjects (65.6 Ϯ 0.9 yr). Second, in an intervention study, we examined the effects of 8-wk aerobic exercise training on serum adropin level and arterial stiffness in 40 healthy middle-aged and older subjects (67.3 Ϯ 1.0 yr) divided into two groups: aerobic exercise training and sedentary controls. In the cross-sectional study, serum adropin level was negatively correlated with carotid ␤-stiffness (r ϭ Ϫ0.437, P Ͻ 0.001) and positively correlated with plasma NOx level (r ϭ 0.493, P Ͻ 0.001) and cardiorespiratory fitness (r ϭ 0.457, P Ͻ 0.001). Serum adropin levels were elevated after the 8-wk aerobic exercise training intervention, and training-induced changes in serum adropin level were correlated with traininginduced changes in carotid ␤-stiffness (r ϭ Ϫ0.399, P Ͻ 0.05) and plasma NOx level (r ϭ 0.623, P Ͻ 0.001). Thus the increase in adropin may participate in the exercise-induced reduction of arterial stiffness. ARTERIAL STIFFNESS increases with age (26) owing to declines in endothelial function and autonomic function and increases in arterial wall thickness and calcification (1,3,4,11,18,24,26,31). This functional deterioration impairs the conduit and buffering functions of arteries, leading to several pathological conditions, including hypertension, atherosclerosis, and stroke (1,4,18,26). A cross-sectional study revealed that arterial stiffness was lower in individuals with higher levels of cardiorespiratory fitness (23, 28). Furthermore, habitual aerobic exercise reduces arterial stiffness (10, 28).Adropin consists of 76 amino acids and is encoded by a gene, Energy Homeostasis Associated (Enho) (16), and expressed in multiple tissues, including the brain, heart, kidney, liver, pancreas, skeletal muscle, and small intestine (2, 32). Circulating adropin level decreases with age (7). Recent work showed that adropin is expressed in vascular endothelial cells and promotes nitric oxide (NO) release by regulating endothelial nitric oxide synthase (eNOS) expression via vascul...

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Section: Discussionmentioning

confidence: 99%

Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults

Fujie

Hasegawa

Sato

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

show abstract

“…An in vitro laboratory experi-ment showed that adropin-treated endothelial cells exhibited greater proliferation, migration, capillary-like tube formation and upregulation of the expression of endothelial nitric oxide synthase (eNOS) (16). Furthermore, previous studies have also reported that a lower serum adropin level is associated with acute myocardial infarction and the angiographic severity of coronary atherosclerosis (18,19).…”

Section: Introductionmentioning

confidence: 99%

Adropin is associated with hyperhomocysteine and coronary atherosclerosis

Zhao

You

Chan

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Homocysteine has been recognized as a risk factor for atherosclerosis and cardiovascular diseases. Adropin is a newly-identified energy homeostasis protein with a potential protective effect against coronary artery disease (CAD). This study attempted to measure the correlation between serum homocysteine and adropin levels in patients with CAD, and to ascertain how the two hormones could affect the severity of coronary atherosclerosis. A cohort of CAD patients who had undergone coronary angiography was prospectively recruited. The serum homocysteine and adropin levels of the patients were measured and the severity of coronary atherosclerosis was quantified with the SYNTAX score. The data were analyzed with a generalized structural equation model. In total, 170 consecutive patients were recruited with a mean serum homocysteine level of 15.9±8.3 µmol/l, and 76 (44.7%) patients were identified as hyperhomocysteinemic with a serum homocysteine level >15 µmol/l. Serum homocysteine level was found to be significantly negatively correlated with serum adropin level (r=-0.169, P=0.028). Patients with hyperhomocysteinemia had lower serum adropin levels and higher SYNTAX scores than patients without hyperhomocysteinemia. Further analysis with a generalized structural equation model showed that adropin was significantly associated with hyperhomocysteinemia (adjusted odds ratio: 0.95, 95% confidence interval: 0.93 to 0.98; P=0.002), which in turn was significantly associated with the SYNTAX score (coefficient: 4.71, 95% confidence interval: 1.39 to 8.03; P=0.005). In conclusion, the serum homocysteine level was inversely correlated with the serum adropin level in patients with CAD. A low serum adropin level was associated with hyperhomocysteinemia and more severe coronary atherosclerosis, as reflected by a higher SYNTAX score.

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“…Adropin concentrations increased after Roux-en-Y gastric bypass, peaking 3 months after surgery [24]. Again in another study, patients including acute myocardial infarction had inverse correlation with adropin and BMI [25]. In contrary, in a research performed in patients with heart failure, including both male and females, adropin concentrations were positively correlated with BMI [26].…”

Section: Discussionmentioning

confidence: 91%