Adropin is associated with hyperhomocysteine and coronary atherosclerosis

Zhao, Ling; You, Tao; Chan, Siew‐Pang; Chen, Jianchang; Xu, Weiting

doi:10.3892/etm.2015.2954

Cited by 37 publications

(33 citation statements)

References 43 publications

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“…The available data regarding the role of adropin and relationships with the development with metabolic diseases, are inconsistent. Reduced levels of adropin have been observed in obesity-associated insulin resistance, gestational diabetes, nonalcoholic fatty liver disease (NAFLD), acute myocardial infarction, coronary atherosclerosis and endothelial dysfunction [7,8]. Sayin et al have demonstrated that low adropin concentrations were associated with the risk of NAFLD (18).…”

Section: Discussionmentioning

confidence: 99%

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Afamin and adropin in patients with alcohol-induced liver cirrhosis

Prystupa¹,

Kiciński²,

Luchowska-Kocot³

et al. 2018

Ann Agric Environ Med.

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The aim of the study was to determine serum concentrations of afamin and adropin in patients with alcoholic liver cirrhosis and to define their correlation with the stage of disease. The study included 99 patients with alcoholic cirrhosis from the region of Lublin, (Eastern Poland). Liver cirrhosis was diagnosed based on clinical features, history of heavy alcohol consumption, laboratory tests and abdominal ultrasonography. The control group consisted of 20 healthy individuals without liver disease who did not abuse alcohol. The serum afamin and adropin concentrations were determined using ELISA kits. The concentration of afamin was found to be significantly lower in patients with compensated alcoholic liver cirrhosis, i.e. P-Ch B (85.1±40.6 μg/ml) and P-Ch C (56.4±32.3 μg/ml) individuals, compared to the control group (135.9±43.6 μg/ml); p-value was <0.01 and <0.001, respectively. As far as adropin is concerned, a reverse relationship was demonstrated: the highest concentration was found in patients with P-Ch C (11.7±5.7 ng/ml) cirrhosis. Furthermore, the above concentration was significantly higher compared to patients with P-Ch A cirrhosis (7.2±2.8 ng/ml; p<0.05) and controls (7.5±2.6 ng/ml; p<0.05). The concentration of afamin decreases with the severity of alcoholic liver cirrhosis, which most likely results from impaired hepatic synthesis. Otherwise, the higher the stage of disease according to the Child-Pugh score, the higher the concentration of adropin.

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Section: Discussionmentioning

confidence: 99%

“…Adropin is a peptide hormone involved in energy homeostasis and regulation of metabolism of glucose and fatty acids [7]. It has been suggested that a low serum adropin level may be associated with more severe coronary atherosclerosis [8].…”

Section: Introductionmentioning

confidence: 99%

Afamin and adropin in patients with alcohol-induced liver cirrhosis

Prystupa¹,

Kiciński²,

Luchowska-Kocot³

et al. 2018

Ann Agric Environ Med.

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“…Adropin ameliorates murine limb perfusion and increases capillary density following hindlimb ischemia in mice [ 6 ]. Several lines of clinical evidence have shown that blood adropin levels are decreased in coronary artery disease (CAD), diabetes, metabolic syndrome, and obesity, and correlated negatively with the severity of CAD, body mass index, age, homeostasis model assessment of insulin resistance (HOMA-IR), insulin and homocysteine levels, and endothelial dysfunction in patients with diabetes, metabolic syndrome, and obesity [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. However, the effects of adropin on atherogenesis have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Adropin Contributes to Anti-Atherosclerosis by Suppressing Monocyte-Endothelial Cell Adhesion and Smooth Muscle Cell Proliferation

Sato

Yamashita

Shirai

et al. 2018

IJMS

101

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Adropin, a peptide hormone expressed in liver and brain, is known to improve insulin resistance and endothelial dysfunction. Serum levels of adropin are negatively associated with the severity of coronary artery disease. However, it remains unknown whether adropin could modulate atherogenesis. We assessed the effects of adropin on inflammatory molecule expression and human THP1 monocyte adhesion in human umbilical vein endothelial cells (HUVECs), foam cell formation in THP1 monocyte-derived macrophages, and the migration and proliferation of human aortic smooth muscle cells (HASMCs) in vitro and atherogenesis in Apoe−/− mice in vivo. Adropin was expressed in THP1 monocytes, their derived macrophages, HASMCs, and HUVECs. Adropin suppressed tumor necrosis factor α-induced THP1 monocyte adhesion to HUVECs, which was associated with vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 downregulation in HUVECs. Adropin shifted the phenotype to anti-inflammatory M2 rather than pro-inflammatory M1 via peroxisome proliferator-activated receptor γ upregulation during monocyte differentiation into macrophages. Adropin had no significant effects on oxidized low-density lipoprotein-induced foam cell formation in macrophages. In HASMCs, adropin suppressed the migration and proliferation without inducing apoptosis via ERK1/2 and Bax downregulation and phosphoinositide 3-kinase/Akt/Bcl2 upregulation. Chronic administration of adropin to Apoe−/− mice attenuated the development of atherosclerotic lesions in the aorta, with reduced the intra-plaque monocyte/macrophage infiltration and smooth muscle cell content. Thus, adropin could serve as a novel therapeutic target in atherosclerosis and related diseases.

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“…(1) Hcy: Hcy is known to mediate cardiovascular problems by its adverse effects on cardiovascular endothelium and smooth muscle cells with resultant alterations in subclinical arterial structure and function. Serum Hcy level is negatively correlated with serum adropin level in CAD patients [33]. Hyperhomocysteinemia activates c-Jun N-terminal kinase by inducing endoplasmic reticulum stress, which can stimulate the production of proinflammatory cytokines and promote macrophage infiltration, thereby promoting insulin resistance [34].…”

Section: Correlation Between Inhibition Of Inflammation By Adropin Anmentioning

confidence: 99%

A Review of Adropin as the Medium of Dialogue between Energy Regulation and Immune Regulation

Zhang

Chen

Lin

et al. 2020

Oxidative Medicine and Cellular Longevity

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Adropin is a secretory protein encoded by the energy balance gene and is closely associated with regulation of energy metabolism and insulin resistance. The clinical findings demonstrated its decreased expression in various inflammatory diseases, its negative correlation with the expression levels of inflammatory cytokines, and its potential anti-inflammatory effects. We speculate that adropin plays a pivotal regulatory role in immune cells and inflammatory factors. In this study, we reviewed the advances in researches concentrated on immunological effects of adropin.

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Adropin is associated with hyperhomocysteine and coronary atherosclerosis

Cited by 37 publications

References 43 publications

Afamin and adropin in patients with alcohol-induced liver cirrhosis

Afamin and adropin in patients with alcohol-induced liver cirrhosis

Adropin Contributes to Anti-Atherosclerosis by Suppressing Monocyte-Endothelial Cell Adhesion and Smooth Muscle Cell Proliferation

A Review of Adropin as the Medium of Dialogue between Energy Regulation and Immune Regulation

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