Afamin and adropin in patients with alcohol-induced  liver cirrhosis

Prystupa, Andrzej; Kiciński, Paweł; Luchowska-Kocot, Dorota; Sak, Jarosław; Prystupa, Tomasz; Chen, Ko-Hsin; Chen, Yu-Chieh; Panasiuk, Lech; Załuska, Wojciech

doi:10.26444/aaem/92650

Cited by 10 publications

(10 citation statements)

References 18 publications

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“…Related results were reported by Chen in mice [10]. On the other hand, other studies showed an increase in serum adropin levels in liver cirrhotic and hepatitis patients [11,12].…”

Section: Introductionsupporting

confidence: 78%

Adropin is Involved in the Ameliorative Effect of Chronic Exercise in Non-alcoholic Fatty Liver Rat Model

Fathy

Zamzam

Gergis

et al. 2023

Zagazig University Medical Journal

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Background: Non-alcoholic fatty liver disease (NAFLD) is characterized by abnormal fat metabolism in the liver due to nonalcoholic causes. Adropin is a peptide hormone with an essential role in maintaining metabolic homeostasis. Methods: 42 male rats were divided into 2 groups, each group was subdivided into 3 subgroups: group Ia: control 4 weeks; group Ib: high fat diet (HFD) 4 weeks, group Ic: HFD 4 weeks +exercise; group IIa: control 12 weeks, group IIb: HFD 12 weeks; and group IIc: HFD 12 weeks + exercise. Serum Adropin, glucose, HOMA-IR, insulin, lipid profile, ALT, AST, TNFα, IL6, hepatic ROS, MDA, and SOD were measured. Histopathological examination, immunohistochemical study, and Mallory's trichrome staining of the liver were performed. Results: significant increases in insulin resistance, lipid profile parameters, ALT, AST, TNFα, IL6, hepatic ROS, MDA, and a decrease in SOD were found in HFD groups. Histopathological examination revealed steatosis in group Ib and steatohepatitis in group IIb. These changes were associated with a decrease in serum adropin levels. Exercise in groups Ic and IIc improved these changes with a significant increase in adropin level. Conclusion: HFD induced functional and structural deterioration in the liver, leading to NAFLD with a significant decrease in serum adropin level. Exercise induced a significant increase in serum adropin, which may have a role in the remission of hepatic inflammation, steatosis, and steatohepatitis.

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“…Related results were reported by Chen in mice [10]. On the other hand, other studies showed an increase in serum adropin levels in liver cirrhotic and hepatitis patients [11,12].…”

Section: Introductionsupporting

confidence: 78%

Adropin is Involved in the Ameliorative Effect of Chronic Exercise in Non-alcoholic Fatty Liver Rat Model

Fathy

Zamzam

Gergis

et al. 2023

Zagazig University Medical Journal

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“…While some have been implicated in liver disease confirming previously published findings, such as C7 (ref. 50 ), LGALS3BP 51 , TGFBI 52 , ALDOB 21 , AFM 21 , 53 , TTR 54 , QSOX1 (ref. 52 ), F2 (ref.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive proteomic biomarkers for alcohol-related liver disease

Niu

Thiele

Geyer

et al. 2022

Nat Med

127

101

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Alcohol-related liver disease (ALD) is a major cause of liver-related death worldwide, yet understanding of the three key pathological features of the disease—fibrosis, inflammation and steatosis—remains incomplete. Here, we present a paired liver–plasma proteomics approach to infer molecular pathophysiology and to explore the diagnostic and prognostic capability of plasma proteomics in 596 individuals (137 controls and 459 individuals with ALD), 360 of whom had biopsy-based histological assessment. We analyzed all plasma samples and 79 liver biopsies using a mass spectrometry (MS)-based proteomics workflow with short gradient times and an enhanced, data-independent acquisition scheme in only 3 weeks of measurement time. In plasma and liver biopsy tissues, metabolic functions were downregulated whereas fibrosis-associated signaling and immune responses were upregulated. Machine learning models identified proteomics biomarker panels that detected significant fibrosis (receiver operating characteristic–area under the curve (ROC–AUC), 0.92, accuracy, 0.82) and mild inflammation (ROC–AUC, 0.87, accuracy, 0.79) more accurately than existing clinical assays (DeLong’s test, P < 0.05). These biomarker panels were found to be accurate in prediction of future liver-related events and all-cause mortality, with a Harrell’s C-index of 0.90 and 0.79, respectively. An independent validation cohort reproduced the diagnostic model performance, laying the foundation for routine MS-based liver disease testing.

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“…These levels were further reduced in NAFLD patients with insulin resistance 10 . In a study of 99 patients with alcoholic cirrhosis, increased adropin levels were associated with increased severity of the liver dysfunction as assessed by the Child–Pugh score 17 …”

Section: The Role Of Adropin In Regulation Of Metabolic Pathways and mentioning

confidence: 98%

“…10 In a study of 99 patients with alcoholic cirrhosis, increased adropin levels were associated with increased severity of the liver dysfunction as assessed by the Child-Pugh score. 17 Enho gene expression in the liver is regulated by nutrition. In fed conditions, adropin levels are regulated by dietary macronutrients and increase with dietary fat content.…”

Section: The Role Of Adropin In Regulation Of Metabolic Pathways Anmentioning

confidence: 99%

Adropin as a potential mediator of the metabolic system‐autonomic nervous system‐chronobiology axis: Implementing a personalized signature‐based platform for chronotherapy

2020

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Adropin is a peptide hormone, which plays a role in energy homeostasis and controls glucose and fatty acid metabolism. Its levels correlate with changes in carbohydratelipid metabolism, metabolic diseases, central nervous system function, endothelial function and cardiovascular disease. Both metabolic pathways and adropin are regulated by the circadian clocks. Here, we review the roles of the autonomic nervous system and circadian rhythms in regulating metabolic pathways and energy homeostasis. The beneficial effects of chronotherapy in various systems are discussed. We suggest a potential role for adropin as a mediator of the metabolic system-autonomic nervous system axis. We discuss the possibility of establishing an individualized adropin and circadian rhythm-based platform for implementing chronotherapy, and variability signatures for improving the efficacy of adropin-based therapies are discussed. K E Y W O R D S adropin, autonomic nervous system, chronobiology, metabolic syndrome 1 | INTRODUCTION Metabolic syndrome (MetS) is a cluster of metabolic and cardiovascular complications, which increase the risk of cardiovascular diseases (CVD) and type 2 diabetes (T2D). 1 The pathogenesis of MetS involves multiple factors, including the autonomic nervous system (ANS) and the circadian rhythm. 2 Recently, MetS was also shown to increase the risk and mortality of cancer, 3 with which it shares many risk factors including age, genetic factors, obesity, physical inactivity, unhealthy diet, alcohol, smoking, endocrine disruptors exposure and air pollution. Recent studies have suggested that several peptide hormones play important roles in the modulation of systemic metabolism and energy homeostasis. Adropin is a product of the energy homeostasis associated (Enho) gene and a peptide hormone that plays a role in the regulation of energy homeostasis and controls glucose and fatty acid metabolism. It was originally described as a secreted peptide, with

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Afamin and adropin in patients with alcohol-induced liver cirrhosis

Cited by 10 publications

References 18 publications

Adropin is Involved in the Ameliorative Effect of Chronic Exercise in Non-alcoholic Fatty Liver Rat Model

Adropin is Involved in the Ameliorative Effect of Chronic Exercise in Non-alcoholic Fatty Liver Rat Model

Noninvasive proteomic biomarkers for alcohol-related liver disease

Adropin as a potential mediator of the metabolic system‐autonomic nervous system‐chronobiology axis: Implementing a personalized signature‐based platform for chronotherapy

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