Serum 25-hydroxyvitamin D levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant women

Agudelo-Zapata, Yessica; Maldonado-Acosta, Luis Miguel; Sandoval-Alzate, Héctor Fabio; Poveda, Natalia E.; Garcés, María Fernanda; Cortés-Vásquez, Jonathan Alexander; Linares-Vaca, Andres Felipe; Mancera-Rodríguez, Carlos Alejandro; Perea-Ariza, Shahar Alexandra; Ramírez-Iriarte, Karen Yuliana; Castro-Saldarriaga, Camilo Andrés; Arteaga-Díaz, Juan Manuel; Franco-Vega, Roberto; Angel‐Müller, Edith; Baños, Arturo José Parada; Caminos, Jorge Eduardo

doi:10.1530/ec-18-0055

Cited by 9 publications

(7 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean serum 25-OHD level during pregnancy was 23.36 ng/mL, ranging from 10.6-45.5 ng/mL [25]. In line with our results, several other studies have observed lower levels of serum 25-OHD in the first trimester as compared to the latter two [26,27]. This may be due to the significantly higher conversion rate of 25-OHD to 1.25(OH)D during the first trimester, as compared to the conversion of vitamin D to 25-OHD, which remains unchanged during the same period [28].…”

Section: Discussionsupporting

confidence: 91%

Maternal Vitamin D and Newborn Telomere Length

et al. 2021

View full text Add to dashboard Cite

Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother–child pairs enrolled in the Maternal Nutrition and Offspring’s Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth.

show abstract

Section: Discussionsupporting

confidence: 91%

Maternal Vitamin D and Newborn Telomere Length

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Rapid cardiometabolic and hormonal changes during pregnancy results in dynamic alterations in maternal 25(OH)D metabolism and circulating concentrations throughout pregnancy [ 6 ]. There is some evidence from recent studies that 25(OH)D increases throughout pregnancy [ 11 , 12 , 13 , 14 ]. As such, the gestational age when maternal 25(OH)D is measured may play a role in different findings of the associations between 25(OH)D and neonatal anthropometry.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Maternal Vitamin D Status during Pregnancy Is Associated with Neonatal Anthropometric Measures

et al. 2018

View full text Add to dashboard Cite

Findings on maternal 25-hydroxyvitamin D (25[OH]D) and neonatal anthropometry are inconsistent, and may at least be partly due to variations in gestational week (GW) of 25(OH)D measurement and the lack of longitudinal 25(OH)D measurements across gestation. The aim of the current study was to examine the associations of longitudinal measures of maternal 25(OH)D and neonatal anthropometry at birth. This study included 321 mother–offspring pairs enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies–Singletons. This study was a prospective cohort design without supplementation and without data on dietary supplementation. Nevertheless, measurement of plasma 25(OH)D reflects vitamin D from different sources, including supplementation. Maternal concentrations of total 25(OH)D were measured at 10–14, 15–26, 23–31, and 33–39 GW and categorized as <50 nmol/L, 50–75 nmol/L, and >75 nmol/L. Generalized linear models were used to examine associations of 25(OH)D at each time-point with neonate birthweight z-score, length, and sum of skinfolds at birth. At 10–14 GW, 16.8% and 49.2% of women had 25(OH)D <50 nmol/L and between 50–75 nmol/L, respectively. The association of maternal 25(OH)D with neonatal anthropometry differed by GW and women’s prepregnancy BMI (normal (<25.0 kg/m2), overweight/obese (25.0–44.9 kg/m2)). All analyses were stratified by prepregnancy BMI status. Among women with an overweight/obese BMI, 25(OH)D <50 nmol/L at 10–14 GW was associated with lower birthweight z-score (0.56; 95% CI: −0.99, −0.13) and length (−1.56 cm; 95% CI: −3.07, −0.06), and at 23–31 GW was associated with shorter length (−2.77 cm; 95% CI: −13.38, −4.98) and lower sum of skinfolds (−9.18 mm; 95% CI: −13.38, −4.98). Among women with a normal BMI, 25(OH)D <50 nmol/L at 10–14 GW was associated with lower sum of skinfolds (−2.64 mm; 95% CI: −5.03, −0.24), at 23–31 GW was associated with larger birthweight z-scores (0.64; 95% CI: 0.03, 1.25), and at 33-39 GW with both higher birthweight z-score (1.22; 95% CI: 0.71, 1.73) and longer length (1.94 cm; 95% CI: 0.37, 3.52). Maternal 25(OH)D status during pregnancy was associated with neonatal anthropometric measures, and the associations were specific to GW of 25(OH)D measurement and prepregnancy BMI.

show abstract

“…However, the findings might not be generalizable to the other populations. In the present study, maternal Vitamin D levels were measured once in late pregnancy, as evidence has shown that maternal 25(OH)D levels were the highest in late pregnancy and were associated with infants' serum 25(OH)D [41][42][43]. However, our study was unable to determine the changes in maternal Vitamin D levels over the course of pregnancy and their effects on the study outcomes.…”

Section: Discussionmentioning

confidence: 80%

Maternal Vitamin D Levels during Late Pregnancy and Risk of Allergic Diseases and Sensitization during the First Year of Life—A Birth Cohort Study

et al. 2020

View full text Add to dashboard Cite

Allergic diseases are the most common chronic illness in childhood. Findings from developed countries have reported associations between Vitamin D levels during pregnancy and offspring allergy risk. This prospective cohort study aimed to determine the associations between maternal Vitamin D levels during late pregnancy and allergic diseases in Malaysian infants during the first year of life. Serum 25(OH)D concentrations of 380 pregnant women in the third trimester were measured using a chemiluminescent immunoassay. Children’s allergic outcomes were assessed at 3, 6, and 12 months based on parental reports. Specific IgE antibodies against food and inhalant allergens were measured in infants at 12 months of age. A total of 43.2% pregnant women were Vitamin D deficient (<30 nmol/L) and 56.8% were nondeficient (≥30 nmol/L). A total of 27.6% of the infants had eczema, 6.1% had wheeze, 27.4% had food sensitization, 10.8% had inhalant allergen sensitization, and 3.8% had IgE-mediated food allergy during the first year of life. Compared with the nondeficient group, maternal Vitamin D deficiency in late pregnancy was not associated with any allergic outcomes after adjustment for potential confounding factors. In conclusion, the present study does not support an association between maternal Vitamin D levels in late pregnancy and allergic outcomes during the first year of life.

show abstract

Serum 25-hydroxyvitamin D levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant women

Cited by 9 publications

References 37 publications

Maternal Vitamin D and Newborn Telomere Length

Maternal Vitamin D and Newborn Telomere Length

Longitudinal Maternal Vitamin D Status during Pregnancy Is Associated with Neonatal Anthropometric Measures

Maternal Vitamin D Levels during Late Pregnancy and Risk of Allergic Diseases and Sensitization during the First Year of Life—A Birth Cohort Study

Contact Info

Product

Resources

About