Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome

Yıldızhan, Recep; Kurdoğlu, Mertihan; Adalı, Ertan; Kolusarı, Ali; Yıldızhan, Begüm; Şahin, Hanım Güler; Kamacı, Mansur

doi:10.1007/s00404-009-0958-7

Cited by 192 publications

(209 citation statements)

References 28 publications

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“…These results conflict with previous studies' findings that hypovitaminosis D is associated with PCOS (1). Furthermore, other authors have suggested that vitamin D deficiency is associated with PCOS only among obese women (30,31). Moreover, another study found that hypovitaminosis D was associated with insulin resistance, regardless of the patient's body mass index (32).…”

Section: Resultsmentioning

confidence: 98%

Highly prevalence of vitamin D deficiency among Brazilian women of reproductive age

Lopes

Brasileiro

et al. 2017

Arch. Endocrinol. Metab.

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Section: Resultsmentioning

confidence: 98%

Highly prevalence of vitamin D deficiency among Brazilian women of reproductive age

Lopes

Brasileiro

et al. 2017

Arch. Endocrinol. Metab.

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“…[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] Some of the most recent information about low vitamin D status and obesity comes from studies in bariatric surgery patients, reporting low preoperative circulating levels of 25-hydroxyvitamin D. [21][22][23][24][25][26][27][33][34][35][36][37][38] In fact, a recent systematic review of 14 studies with about 1500 patients undergoing bariatric surgical procedures confirmed that obese individuals have serum 25-hydroxyvitamin D levels below 80 nmol l À1 preoperatively. 39 Other investigators have reported that body mass index (BMI) 25,26,[40][41][42][43][44][45][46] and body fat 20,45,[47][48][49]…”

Section: Methodsmentioning

confidence: 99%

The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications

et al. 2011

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Obesity and vitamin D deficiency have both been recognized as major public health issues worldwide, and there is growing evidence that they are related, although the cause-effect relationship remains unclear. Could obesity be contributing to low circulating 25-hydroxyvitamin D concentrations? Alternatively, could low vitamin D status predispose to obesity? In this review, the relationship between low circulating 25-hydroxyvitamin D and obesity, and possible underlying reasons from both perspectives, is presented. One potential mechanism by which obesity could contribute to low serum 25-hydroxyvitamin D is adipose sequestration of vitamin D. On the other hand, adipose tissue has both the vitamin D receptor and the ability to synthesize 1,25-dihydroxyvitamin D, and there is evidence that vitamin D may regulate adipose tissue mass, differentiation and metabolism in ways that might contribute to obesity. Of particular interest, vitamin D deficiency is common both before and after bariatric surgery, and is often difficult to treat, particularly with the more malabsorptive procedures. Additional research is needed to elucidate the complex and multifaceted factors underlying the association between low circulating 25-hydroxyvitamin D and obesity, and to identify optimal treatment approaches in obese individuals and in bariatric surgical patients both before and after surgery.

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“…Twelve studies had an observational design (18,19,20,21,22,23,24,25,26,27,28,29), employing a crosssectional or case-control design, with vitamin D status as one of the preliminary outcomes. A summary of these studies is given in Table 1.…”

Section: The Association Between Vitamin D Status and Metabolic Distumentioning

confidence: 99%

“…The studies included premenopausal women (14-50 years) of various ethnicities, with the number of participants ranging from 45 to 400. Different stratifications were used: seven studies compared PCOS women with controls (19,20,22,23,24,27,28), three studies compared lean vs obese PCOS women (18,21,26), one study compared PCOS women with and without the metabolic syndrome (25), and one study solely included PCOS women (29). Large differences were found in the prevalence of vitamin D deficiency (defined as serum 25OHD levels !50 nmol/l), varying from 37% in a study carried out in Italy (21) to 72% in a study carried out in Scotland (19).…”

Section: The Association Between Vitamin D Status and Metabolic Distumentioning

confidence: 99%

The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

Krul-Poel

Snackey

Louwers

et al. 2013

European Journal of Endocrinology

109

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Context: Metabolic disturbances, in particular, insulin resistance (IR) and dyslipidemia, are common in women suffering from polycystic ovary syndrome (PCOS). Evidence is accumulating that vitamin D status may contribute to the development of metabolic disturbances in PCOS. Objective: The aim of this study was to carry out a systematic review addressing the association between vitamin D status, vitamin D receptor polymorphisms, and/or polymorphisms related to vitamin D metabolism and metabolic disturbances in women with PCOS. Design and methods: A systematic search of electronic databases was carried out up to January 2013 for observational studies and clinical trials in women suffering from PCOS with outcome measures that were related to vitamin D status. We conducted univariate and multivariate regression analyses of the weighted means to gain insights into the association between vitamin D, BMI, and IR based on existing literature. Results: We found 29 eligible trials with inconsistency in their results. One well-designed randomized controlled trial has been carried out until now. Univariate regression analyses of the weighted means revealed vitamin D to be a significant and independent predictor of IR in both PCOS and control women. The significance disappeared after adjustment for BMI in PCOS women. Conclusions: Current evidence suggests an inverse association between vitamin D status and metabolic disturbances in PCOS. Owing to the heterogeneity of the studies, it is hard to draw a definite conclusion. The causal relationship between vitamin D status and metabolic disturbances in PCOS remains to be determined in well-designed placebo-controlled randomized clinical trials.

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Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome

Abstract: Low serum 25-OH-VD concentrations result from the presence of obesity and insulin resistance. However, the dependency between PCOS and hypovitaminosis D is questionable. Hypovitaminosis D should be kept in mind while managing obese women with PCOS.

Cited by 192 publications

References 28 publications

Highly prevalence of vitamin D deficiency among Brazilian women of reproductive age

Highly prevalence of vitamin D deficiency among Brazilian women of reproductive age

The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications

The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

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