Serum 25 hydroxyvitamin D concentrations in individuals over 80 years old and their correlations with musculoskeletal and health parameters

Foroni, Mariana Zuccolotto; Cendoroglo, Maysa Seabra; Sakane, Eliane Naomi; Marin-Mio, Rosângela Villa; Moreira, Patrícia Ferreira do Prado; Maeda, Sérgio Setsuo; Lazaretti-Castro, Marise

doi:10.1007/s12020-022-03231-4

Cited by 4 publications

(1 citation statement)

References 57 publications

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“…In this respect, a condition of vitamin D deficiency in the Italian population was recently defined for serum 25OHD values <20 ng/mL (50 nmol/L); however, maintaining levels above 30 ng/mL (75 nmol/L) in risk categories, as well as in patients under treatment with antiresorptive or bone osteo-anabolic drugs, has been recommended [ 42 , 43 ]. The consequences of vitamin D deficiency mainly involve bone and muscle, with an increased risk of secondary hyperparathyroidism, fragility fractures, osteomalacia, and enhanced risk of falls, especially in elderly subjects [ 44 ]. Likewise, adequate concentrations of 25OHD are necessary for maximizing the efficacy of anti-osteoporotic drugs [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Vitamin D Intake in Italian Subjects: Validation of a Frequency Food Questionnaire (FFQ)

et al. 2023

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Vitamin D plays a crucial role in calcium and phosphate metabolism, relating to bone health and preventing metabolic bone disorders such as rickets and osteomalacia. Vitamin D deficiency (serum 25-OH-D values <20 ng/mL or 50 nmol/L) is common also in Italian people; it is recommended to maintain levels above 30 ng/mL (75 nmol/L) in categories at risk. Supplementation and/or fortification with either ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) aimed to modify this condition have commonly been proposed. Studies about vitamin D intake are numerous in the literature but not adequately designed and are very often incomplete in Mediterranean Countries such as in the Italian population. On these bases, we performed a survey to validate a frequency food questionnaire (FFQ) specifically created to rapidly assess dietary vitamin D intake in Italian people. For this aim, the data of questionnaires were compared with results derived in the same population from a designed 14-day frequency food diary (FFD). Overall, a good correlation between FFQ and FFD was observed (r = 0.89, p < 0.001), both demonstrating a remarkably low vitamin D intake, irrespective of age and gender. Our data confirm that the vitamin D intake is very low in Italy, which likely contributes to hypovitaminosis D.

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Section: Discussionmentioning

confidence: 99%

Dietary Vitamin D Intake in Italian Subjects: Validation of a Frequency Food Questionnaire (FFQ)

et al. 2023

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A view on vitamin D: a pleiotropic factor?

Giustina,

Lazaretti-Castro,

Martineau

et al. 2024

Nat Rev Endocrinol

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Vitamin D and muscle health: insights from recent studies

Kuwabara,

Matsumoto,

Hatamoto

et al. 2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review The purpose of this review is to critically evaluate the effects of vitamin D on muscle mass and physical/muscle function in middle-aged and older adults, based on recent human studies, including cross-sectional, observational, and intervention studies. Vitamin D, beyond its well established role in bone health, has shown potential in influencing muscle physiology, making it a nutrient of interest in the context of sarcopenia and related chronic conditions. Recent findings The review states how vitamin D affects muscle function, emphasizing its role in muscle cell proliferation, differentiation, and key signaling pathways. Additionally, the review of recent human studies revealed an inconsistent relationship between vitamin D and sarcopenia and related indices, with mixed results regarding muscle mass and strength. Variability in supplementation dose, duration, and baseline 25-hydroxyvitamin D levels may contribute to these inconsistencies. Summary While animal studies indicate vitamin D's effectiveness in muscle growth, cross-sectional, observational, and intervention studies do not show clear benefits of maintaining efficient vitamin D levels on muscle mass or function in humans. Although vitamin D impacts muscle health, it is insufficient alone, emphasizing the need for a multifaceted approach to sarcopenia prevention and management.

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Serum 25 hydroxyvitamin D concentrations in individuals over 80 years old and their correlations with musculoskeletal and health parameters

Cited by 4 publications

References 57 publications

Dietary Vitamin D Intake in Italian Subjects: Validation of a Frequency Food Questionnaire (FFQ)

Dietary Vitamin D Intake in Italian Subjects: Validation of a Frequency Food Questionnaire (FFQ)

A view on vitamin D: a pleiotropic factor?

Vitamin D and muscle health: insights from recent studies

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