A view on vitamin D: a pleiotropic factor?

Giustina, Andrea; Lazaretti-Castro, Marise; Martineau, Adrian R.; Mason, Rebecca S.; Rosen, Clifford J.; Schoenmakers, Inez

doi:10.1038/s41574-023-00942-0

Nat Rev Endocrinol

2024

DOI: 10.1038/s41574-023-00942-0

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A view on vitamin D: a pleiotropic factor?

Andrea Giustina,

Marise Lazaretti-Castro,

Adrian R. Martineau

et al.

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2024

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Cited by 5 publications

References 22 publications

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High prevalence of morphometric vertebral fractures opportunistically detected on thoracic radiograms in patients with non-functioning pituitary adenoma

Frara,

Uygur,

Bolamperti

et al. 2024

Pituitary

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High prevalence of morphometric vertebral fractures opportunistically detected on thoracic radiograms in patients with non-functioning pituitary adenoma

Frara,

Uygur,

Bolamperti

et al. 2024

Pituitary

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New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases

di Filippo,

Bilezikian,

Canalis

et al. 2024

Endocrine

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Novel protective circulating miRNA are associated with preserved vitamin D levels in patients with mild COVID-19 presentation at hospital admission not progressing into severe disease

di Filippo,

Terenzi,

Di Ienno

et al. 2024

Endocrine

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Purpose Low vitamin D levels were reported to negatively influence the outcomes of acute COVID-19, as well as other biochemical markers were linked to COVID-19, including microRNAs (miRNAs). This study aimed to prospectively evaluate miRNAs and vitamin D relationship in predicting COVID-19 outcomes. Methods COVID-19 patients were part of a previously reported cohort and enrolled in a matched-ratio based on the presence/or not of severe disease at hospital admission. 25(OH) vitamin D levels and miRNAs expression were evaluated. Results Patients affected by non-severe COVID-19 were characterized by a higher expression of miRNAs hsa-miR-3115 and hsa-miR-7151-3p, as compared to those affected by severe disease. In non-severe patients, these miRNAs were more frequently expressed in those who subsequently did not develop worsening outcomes. In addition, patients with miRNA-7151 expression and without worsening disease were characterized by higher 25(OH) vitamin D levels and lower prevalence of vitamin D deficiency. Conclusions The expression of two novel miRNAs was reported for the first-time to be associated with a less severe COVID-19 form and to prospectively predict the occurrence of disease outcome. Furthermore, the association observed between vitamin D deficiency and lack of miRNA-7151 expression in COVID-19 patients with worse outcomes may support the hypothesis that the co-existence of these two conditions may have a strong negative prognostic role.

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A view on vitamin D: a pleiotropic factor?

Cited by 5 publications

References 22 publications

High prevalence of morphometric vertebral fractures opportunistically detected on thoracic radiograms in patients with non-functioning pituitary adenoma

High prevalence of morphometric vertebral fractures opportunistically detected on thoracic radiograms in patients with non-functioning pituitary adenoma

New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases

Novel protective circulating miRNA are associated with preserved vitamin D levels in patients with mild COVID-19 presentation at hospital admission not progressing into severe disease

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