Serum 25-Hydroxyvitamin D Concentration and Subsequent Risk of Type 2 Diabetes

Mattila, Catharina; Knekt, Paul; Männistö, Satu; Rissanen, Harri; Laaksonen, Maarit A.; Montonen, Jukka; Reunanen, Antti

doi:10.2337/dc07-0292

Cited by 289 publications

(218 citation statements)

References 12 publications

Supporting

Mentioning

197

Contrasting

Unclassified

Order By: Relevance

“…As it is a major challenge to find strategies for the early detection of individuals at high risk of type 2 diabetes, and thereby possibly novel mechanisms for its prevention and early treatment, a few studies have addressed the issue of whether low serum 25(OH)D concentrations can predict the development of type 2 diabetes [7][8][9][10][11][12]. However, some of these reports are limited by, for example, the use of indirect measures or surrogate markers of vitamin D status [11] and type 2 diabetes [9], by a rather small study sample [9] or by an incomplete identification of incident type 2 diabetes [7,8,10]. Thus, further long-term prospective studies involving well-characterised cohorts seem warranted to investigate the predictive value of serum 25(OH)D for type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance

et al. 2012

View full text Add to dashboard Cite

Aims/hypothesis Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on their own or when combined with serum concentrations of IGF-1 or IGF-binding protein-1 (IGFBP-1), which may interact with 25(OH)D. Methods At baseline, participants aged 35-56 years without known type 2 diabetes were examined using OGTTs, 25 (OH)D and IGF peptide measurements, and anthropometric and lifestyle data. Participants who had prediabetes or type 2 diabetes at follow-up 8-10 years later were selected as cases; these were then age-and sex-matched to controls with normal glucose tolerance (NGT) at both baseline and follow-up, giving a total of 980 women and 1,398 men. Results Men but not women in the highest quartile of 25 (OH)D level had a decreased OR for developing type 2 diabetes after adjustment for confounders (OR 0.52, 95% CI 0.30, 0.90), an effect accounted for by individuals with prediabetes, but not with NGT, at baseline. In both sexes, progression from prediabetes to type 2 diabetes was reduced by about 25% per 10 nmol/l increase in 25(OH)D. A high IGFBP-1 value was a better predictor of a reduced risk of type 2 diabetes than high 25(OH)D for both sexes, whereas high IGF-1 concentrations predicted a decreased risk only in men. Conclusions/interpretation High serum 25(OH)D concentrations predict a reduced risk of type 2 diabetes in individuals with prediabetes, but not NGT. There were no significant interactions between 25(OH)D and IGFBP-1 or IGF-1 in terms of risk of diabetes. Our data suggest that vitamin D supplementation should be evaluated for the prevention of type 2 diabetes in prediabetic individuals.

show abstract

Section: Introductionmentioning

confidence: 99%

Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance

et al. 2012

View full text Add to dashboard Cite

show abstract

“…8,9 Several clinical studies have evaluated the role of low 25OHD3 in the pathogenesis of T2DM, but with controversial results. [10][11][12][13][14][15] Recently, a study has looked into prediabetes and 25OHD3 in a representative population in the United States. This study reported that low serum 25OHD3 levels were associated with prediabetes in that population, with a strong correlation when vitamin D levels were lower than 17 ng/ml.…”

Section: Introductionmentioning

confidence: 99%

No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study

et al. 2014

View full text Add to dashboard Cite

CONTEXT AND OBJECTIVE: Several studies have evaluated the role of low 25-hydroxyvitamin D (25OHD3) in the pathogenesis of type 2 diabetes (T2DM) and have presented controversial results. The metabolic processes that culminate in T2DM begin under prediabetic conditions. Our aim was to analyze the association between 25OHD3 and glucose metabolism in individuals who were free from but at elevated risk of diabetes. DESIGN AND SETTING: Cross-sectional study at a tertiary hospital. METHODS: Anthropometric and laboratory profiles were determined in patients with one or more of the following risk factors: hypertension; body mass index (BMI) ≥ 25 kg/m 2 ; waist circumference > 80 cm for women and > 94 cm for men; first-degree relatives with diabetes; women with large-for-gestational-age newborns or with gestational T2DM; HDL-cholesterol (high density lipoprotein) < 35 mg/dl; and triglycerides > 250 mg/dl. The patients were divided into two groups: one with prediabetes (abnormal fasting plasma glucose or oral glucose tolerance test) and the other with normal glucose (euglycemic). RESULTS: There was no statistically significant difference between the prediabetic group (n = 38) and euglycemic group (n = 15) regarding age (66.4 ± 10.6 versus 62.6 ± 9.1 years), gender (52.6 versus 73.3% female) and BMI (30.1 ± 4.61 versus 27.9 ± 4.7 kg/m 2 ). Low serum levels of 25OHD3 were found in both groups, without any statistically significant difference between them (29.1 ± 11.8 versus 26.87 ± 9.2 ng/dl). CONCLUSION: There was no association between 25OHD3 levels and the clinical or laboratorial variables analyzed.RESUMO CONTEXTO E OBJETIVO: Vários estudos já avaliaram o papel da 25-hidroxivitamina D (25OHD3) na patogênese do diabetes tipo 2 (DM2) e apresentaram resultados controversos. Os processos metabólicos que culminam no DM2 se iniciam no pré-diabetes. Nosso objetivo foi analisar a associação da 25OHD3 com o metabolismo glicêmico em indivíduos sem diagnóstico mas com alto risco para diabetes. TIPO DE ESTUDO E LOCAL: Estudo transversal em hospital terciário. MÉTODOS:Medidas antropométricas e laboratoriais foram determinadas em pacientes com um ou mais dos fatores de risco: hipertensão; índice de massa corpórea (IMC) ≥ 25 kg/m 2 ; circunferência abdominal > 80 cm no sexo feminino e > 94 cm no sexo masculino; parentes de primeiro grau com diabetes; mulheres com filho nascido grande para idade gestacional ou com DM2 na gravidez; colesterol HDL (high density lipoprotein) < 35 mg/dl e triglicerídeo > 250 mg/dl. Os pacientes foram divididos em dois grupos: um com pré-diabetes (glicemia de jejum ou teste de tolerância oral à glicose alterados) e outro com glicose normal (euglicêmicos). RESULTADOS: Entre pré-diabéticos (n = 38) e euglicêmicos (n = 15) não houve diferença estatística na idade (66,4 ± 10,6 versus 62,6 ± 9,1 anos), gênero (52,6 versus 73,3% feminino) e IMC (30,1 ± 4,61 versus 27,9 ± 4,7 kg/m 2 ). Baixos niveis séricos de 25OHD3 foram encontrados nos dois grupos, sem diferença estatística entre eles (29,1 ± 11,8 versu...

show abstract

“…800 IU vitamin D was associated with a 33 % risk reduction of type 2 diabetes compared with those with Ca , 600 mg and , 400 IU vitamin D (83) . Baseline serum 25(OH)D levels were inversely associated with the risk of type 2 diabetes in the Min-Finland Health Survey of 4097 eligible participants followed for 17 years (84) . The relative risk (RR) of the highest (mean 70·9 nmol/l) to the lowest (mean 22·4 nmol/l) serum 25(OH)D quartiles was 0·60 (84) .…”

Section: Vitamin D and Type 2 Diabetesmentioning

confidence: 99%

“…Baseline serum 25(OH)D levels were inversely associated with the risk of type 2 diabetes in the Min-Finland Health Survey of 4097 eligible participants followed for 17 years (84) . The relative risk (RR) of the highest (mean 70·9 nmol/l) to the lowest (mean 22·4 nmol/l) serum 25(OH)D quartiles was 0·60 (84) . In a combined analysis of two nested case -control studies with 412 cases and 986 controls in the Finnish Mobile Clinic Health Examination Survey (19 518 men and women aged $ 20 years) and the Mini-Finland Health Survey (8000 individuals aged $ 30 years) followed for 22 and 17 years, respectively, the relative odds of the highest (mean about 75 nmol/l) relative to the lowest (mean about 24 nmol/l) quartiles of baseline serum 25(OH)D was 0·28 for type 2 diabetes in men but not significant in women who had lower serum 25(OH)D (highest quartile mean about 63 nmol/l) (82) .…”

Section: Vitamin D and Type 2 Diabetesmentioning

confidence: 99%

Epidemiology of vitamin D in health and disease

Wang

2009

Nutr. Res. Rev.

View full text Add to dashboard Cite

Results from ecological, case -control and cohort studies have shown that vitamin D reduces the risk of bone fracture, falls, autoimmune diseases, type 2 diabetes, CVD and cancer. However, there is still epidemic vitamin D insufficiency especially among individuals living at high latitudes or with dark skin. Serum levels of 25-hydroxyvitamin D (25(OH)D) are considered the best biomarker of vitamin D nutritional status. Appropriate sunshine exposure or oral supplementation is necessary to maintain sufficient vitamin D status, which is generally accepted as serum 25(OH)D . 75 nmol/l. Immunoassays, especially RIA, have been primarily used to measure serum 25(OH)D while liquid chromatography -MS (LC -MS) is considered the 'gold standard'. There is significant disparity among the immunoassays, and all immunoassays have considerable bias compared with LC -MS methods. Because of the variations among the results from these different assays, it is necessary that assay-specific reference ranges be established or standardisation of the assays take place. The present review focuses on ecological, case -control, and cohort studies that investigated the role of vitamin D in health and disease. In addition, analytical techniques used in laboratory evaluation of vitamin D nutritional status are also critically reviewed. The majority of the literature included in the present review is selected from that searchable in PubMed up to the end of September 2008.

show abstract

Serum 25-Hydroxyvitamin D Concentration and Subsequent Risk of Type 2 Diabetes

Cited by 289 publications

References 12 publications

Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance

Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance

No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study

Epidemiology of vitamin D in health and disease

Contact Info

Product

Resources

About